Tom Milne
@milnetom68
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Professor of Haematology at the University of Oxford Views are my own
Oxford, England
Joined December 2017
RT @Sean_Wen221: Delighted to share our work on clonal hematopoiesis #CH out now in @NatureGenet. We revealed ancestry as a risk factor for….
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RT @Sleemmzz: Thrilled to share my 1st brainchild, out today in @NatureGenet ! Been hearing a lot about fetal-like states lately? Here, we….
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RT @andiroy: Well done @ling_r for presenting your DPhil project at OCH Day @MRC_WIMM @OxfordCancer @OxPaediatrics
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RT @disha_kashyap_: #ASO nuclear localisation unlocked via (+)-JQ1 conjugation! We’ve enhanced the splice switching activity and RNase H-re….
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RT @MAF_Dawson: Thrilled to share a wonderful collaboration with @Armstrong_dfci @florian_perner @shellainasci !!. Catalytic inhibition of….
biorxiv.org
Understanding the molecular pathogenesis of MLL fusion oncoprotein (MLL-FP) leukaemia has spawned epigenetic therapies that have improved clinical outcomes in this often-incurable disease. Using...
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bioRxiv paper here: . Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression between patients
biorxiv.org
Genetic alterations alone cannot account for the diverse phenotypes of cancer cells. Even cancers with the same driver mutation show significant transcriptional heterogeneity and varied responses to...
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Congratulations Alastair for a great talk at ASH @MRC_WIMM @andiroy #chromatin #enhancers #genome_architecture:
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Different patients can have unique enhancers driving gene expression in their leukemias:. Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression between patients
biorxiv.org
Genetic alterations alone cannot account for the diverse phenotypes of cancer cells. Even cancers with the same driver mutation show significant transcriptional heterogeneity and varied responses to...
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RT @scienceadvocacy: Last few hours to help fund science-based students across Yorkshire. @gen_res_uk is specifically designed to widen….
unlimited.hubbub.net
Crowdfunding website for projects, ideas & events!
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RT @scienceadvocacy: Trying to unlock a generous donation from a University of York staff member… just need three donors from countries acr….
unlimited.hubbub.net
Crowdfunding website for projects, ideas & events!
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RT @beth_psaila: Thrilled to see this work out @ScienceTM dissecting how MPN cancer cells reprogram their niche to fuel progression, and un….
science.org
Unraveling the cancer-stroma interactome in myelofibrosis reveals galectin-1 as an actionable target.
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RT @sk_kriaucionis: Cost of having DNA methylation: DNA replication by DNA polymerase epsilon is a source of C to T mutations in CpGs, espe….
nature.com
Nature Genetics - A new method called polymerase error rate sequencing (PER-seq) can measure the nucleotide misincorporation rate of DNA polymerases. DNA polymerase ε mutants produce an excess...
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RT @RobKlose: This is a really important new finding from @sk_kriaucionis and team. I would urge everyone to read! Very carefully done and….
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RT @minimolecule: Focal deletions of noncoding regions in cancer genomes can have unexpected consequences. Out now in @BloodJournal, we’ve….
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RT @NatureCellBio: 💫NEW: Combining degron-based depletion with live-cell transcription #imaging and single-particle tracking, @RobKlose, @A….
nature.com
Nature Cell Biology - Combining degron-based depletion with live-cell transcription imaging and single-particle tracking, Szczurek et al. show that Polycomb keeps promoters in an OFF state by...
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RT @andiroy: We say goodbye to @J_W_Cross and @ling_r who both return to clinical haematology training next week. You will be missed in the….
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RT @scienceadvocacy: Calling any UK-based Canadian researchers. I'm organising a meeting at Canada House in July and we're looking for….
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