Disha Kashyap
@disha_kashyap_
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DPhil - Chemistry in Cells, @chem_in_cells at @UniOfOxford • Chemistry undergrad from @StStephensClg • Khorana Scholar’20 • she/her
Joined April 2018
#ASO nuclear localisation unlocked via (+)-JQ1 conjugation! We’ve enhanced the splice switching activity and RNase H-recruitment of antisense oligonucleotides🧬 One of my main DPhil projects #RNAtherapeutics! @DrMikeBooth @milnetom68
@chem_in_cells @OxfordChemistry @MRC_WIMM
We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer! Preprint led by @disha_kashyap_
@milnetom68 @chem_in_cells @OxfordChemistry @UCLChemistry
https://t.co/6j0sW0TbQU
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We’ve integrated DNA nanotech into targeted protein degradation! Our oligoPROTACs act like small mol PROTACs but can be turned “OFF” — exciting alternative to pro-drug based activation for reducing toxicity! @DrMikeBooth @milnetom68
@chem_in_cells @OxfordChemistry @MRC_WIMM
New preprint 🎇 We developed oligonucleotide PROTACs (OligoPROTACs), which show comparable activity to small molecule equivalents - but can be *switched off*, using DNA nanotech, to restore protein levels! Last of @disha_kashyap_'s trilogy! @milnetom68
https://t.co/hW8lrV7ghb
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We have engineered lysosomal trafficking-ASOs (LyTONs)! Novel mechanism of gene knockdown🧬 LyTONs don’t need RNase H recruitment — work as well/better than state-of-the-art gapmers! #RNAtherapeutics
@DrMikeBooth @milnetom68
@chem_in_cells @OxfordChemistry @MRC_WIMM
🚨 Preprint alert 🚨 We have developed an entirely new mechanism of action for ASO gene knockdown -> lysosomal trafficking 🧬! Works with non-DNA ASOs (unlike RNase H mech) and higher activity than corresponding gapmers! Led by @disha_kashyap_ @UCLChemistry @OxfordChemistry
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Had an amazing time at PSL ChemBio symposium! @institut_curie @CNRS A great line up of speakers & stellar science 🧬🧪 A big thank you to the organisers & everyone who stopped by my poster! Honoured to receive a poster prize @RoySocChem @rsc_chembio! Congrats to all winners!
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Read our review on next-generation covalent modifications for nucleic acid therapeutics! 🧬💊
We just published a review in ACS Bio & Med Chem Au on the state-of-the-art and future of covalent nucleic acid conjugates as therapeutics 🧬💊! Led by @disha_kashyap_
@ACSBioMed @ACS_DivBioChem
@UCLChemistry @OxfordChemistry @chem_in_cells
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JQ1 4EVA! @jaybradner @JunQiLab
We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer! Preprint led by @disha_kashyap_
@milnetom68 @chem_in_cells @OxfordChemistry @UCLChemistry
https://t.co/6j0sW0TbQU
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Really cool design: sending ASO to nucleus via conjugating JQ1.
We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer! Preprint led by @disha_kashyap_
@milnetom68 @chem_in_cells @OxfordChemistry @UCLChemistry
https://t.co/6j0sW0TbQU
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Fascinating work showing that the covalent addition of a nuclear importing compound, JQ1, to therapeutic oligonucleotides enhances their activities by enhancing nuclear penetration.
We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer! Preprint led by @disha_kashyap_
@milnetom68 @chem_in_cells @OxfordChemistry @UCLChemistry
https://t.co/6j0sW0TbQU
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Three symposiums over five days - amazing span of interdisciplinary research @chem_in_cells @wellcometrust. Representing @dtc_oxford MSDTC @KirOxford @NDMOxford @OxfordChemistry @MRC_WIMM @CmdOxford
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@EPSRC We've got *2* EPSRC PhD opportunities to join our group in London to study the chemistry and application of nucleic acids, photocages, and polymers! 😍🧬🔦🌡️🧪 https://t.co/JcE4XGWf3O
📢 TWO new PhD positions 📢 Join my group in London to work on controllable nucleic acids for biology and medicine! 🧬🔦🌡️🔊🧫🧪😍 @UCLChemistry Deadline 26th Jan 2023 / Start date Oct 2023 Details in below 🧵
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📢 4th Edition of @RoySocChem Nucleic Acids in Chemistry and Biology has now been released (Blackburn/Gait/Egli/@jwattsgroup) – The bible for scientists who work with nucleic acids Furthermore, I wrote the revamped chapter on DNA and RNA Sequencing! 🥳 https://t.co/1HJFDZ0CU3
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We’re supporting the International Day of Women & Girls in Science to promote full & equal access & participation for women & girls in science. #February11 #womeninscience More @UN
https://t.co/jgCePhrnJg See also Oxford Women in Chemistry @OxWiChem
https://t.co/RJcGigceFF
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Applications to our fully funded Chemistry in Cells programme for 2022 entry is open until 12 noon (UK time) on Friday 21st January 2022. Find out how to apply here: https://t.co/4UgGVEPMOx
#ChemBio @AJR_group @conway_group @chem_in_cells
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Thank you, Mike! A real privilege to work with you & @milnetom68 on establishing, hopefully, a milestone in treating leukaemia! @OxfordChemistry @RDMOxford
@chem_in_cells is an incredible opportunity. Hope to drive meaningful impact in the biomedical sciences with my chemistry!
I'm really excited to welcome @disha_kashyap_ from @chem_in_cells to our group! She will be working on developing novel antisense oligos for childhood leukaemia, jointly with me @OxfordChemistry and @milnetom68 @RDMOxford
https://t.co/75k24R0gsm
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SP हाथरस,वर्दी वाले मालिकों, तुम्हारी पहरेदारी में बेटी की चिता जली है।अंतिम संस्कार के बिना।ये पाप तुमपर है।तुम्हारा क़ानून,तुम्हारा थाना,तुमने सच को झूठ,झूठ को सच बनाया।टूटी गर्दन,आँखों से बहता खून,कटी ज़बान नकारते रहे,गैंगरेप पर सवाल उठाए।अपनी बेटी से नज़र मिला पाओगे?लानत है।
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A few highlights from our WoMentor Connect webinars - a platform to connect young students with professionals in the field!
Dr. Neetu Singh, Associate Professor, IIT Delhi on the post COVID19 life: "We need to establish a new normal- more hygienic practices and physical distancing" Part 2/5 #stemeducation #womenempoweringwomen #womenforwomen #nonprofit #sciencewebinar #covid19 #covid19life
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WoMentor joins Twitter - stay tuned for inspiring content🌸
》A glimpse into our frame of mind at WoMentor. Let's have a moment of science and make it last for a lifetime.《
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Third webinar on ‘Science Careers by Science Communicators’ coming up by WoMentor! Amazing speakers, Subhra Priyadarshini and Dr. Sarah Iqbal, lined up to diversify our interests and pursuits🥰
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We hosted our second webinar with Dr. Anisa Chorwadwala, assistant professor at IISER Pune! Excited to be championing the journeys of inspiring women in STEM.
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A new virus strain, carried by pigs, with pandemic potential- vigilant monitoring can make all the difference. Hopefully, we’re all better prepared!
pnas.org
Pigs are considered as important hosts or “mixing vessels” for the generation of pandemic influenza viruses. Systematic surveillance of influenza v...
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