Yiliang Ding
@YiliangDing
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Tenured Group Leader @JohnInnesCentre, Honorary Professor @uniofeastanglia, Honorary Group Leader @BabrahamInst. Working on RNA structure functionalities
John Innes Centre
Joined January 2011
Super lucky to get the Faraday!@royalsociety Very grateful for the support from @JohnInnesCentre, @CarolineDeanLab, @DingLab_RNA, and all the collaborators/friends🙏 https://t.co/n14xIImUNU
jic.ac.uk
John Innes Centre group leader, Professor Yiliang Ding, has been awarded a prestigious Royal Society Faraday Discovery Fellowship…
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Microscopic “flowers” made from crystals and DNA open and close as the pH of the surrounding solution changes. Learn more in #ScienceAdviser: https://t.co/OikkKpB8FB 📥 Sign up for the daily #newsletter: https://t.co/mcqNeQWWFg
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Cool! Congratulations!
Our new work led by @PatrickGong on expanding the recombinase-based plant synthetic gene circuit toolkit
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1/ Excited to share our new study with @Brumbaugh_JB, now out in @NatureBiotech! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 https://t.co/D7fnkJgNQ6
nature.com
Nature Biotechnology - Stem cell differentiation is controlled by manipulating RNA condensates.
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We're thrilled to announce SeqHub, an AI-enabled platform for biological sequence analysis. SeqHub brings together sequence search, genome annotation, and data sharing in one place. I dreamed of a single place where I could learn everything about my sequences. Today, a much more
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https://t.co/qpXX3Rh8kP: An LLM-Powered Virtual Scientist for Plant Science https://t.co/v3yt3OQu3t
#biorxiv_plants
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Rather than static database, we've made an AI plant scientist that could continuously learn new knowledge😃Hope it will help the plant science community😃 @HaopengYu @JohnInnesCentre @TheSainsburyLab @DingLab_RNA @UniofExeter #AIscientist
We’ve built this virtual plant scientist https://t.co/ESWJls84nu to grow alongside human researchers🌿. It thinks like an expert, cites like a scholar, and never stops learning. Come and have a chat with it! @YiliangDing @JohnInnesCentre @TheSainsburyLab
https://t.co/DyAZCwLCiC
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Proteins as sentences: Language models for learning protein-protein interactions. Proteins rarely act alone. Every biological process — signaling, replication, immunity — is built from interactions between proteins. Yet, while we can now predict the 3D structure of a single
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Accurate protein structure determination from cryo-EM maps using deep learning and structure prediction 1. A new method named EMProt is introduced, which integrates deep learning and structure prediction to accurately determine protein structures from cryo-EM maps. This method
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RiboPO: Preference Optimization for Structure and Stability-Aware RNA Design 1. RiboPO is a novel framework that tackles the complex challenge of RNA sequence design. It optimizes RNA sequences to ensure they adopt specific 3D structures while maintaining thermodynamic
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omicML: An Integrative Bioinformatics and Machine Learning Framework for Transcriptomic Biomarker Identification https://t.co/sh6hD2ymMG
#biorxiv_bioinfo
biorxiv.org
Introduction: Transcriptomic biomarker discovery has been a challenge due to variation in datasets and platforms, complexity in statistical and computational methods, integration of multiple progra...
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Can a single AI model design proteins, peptides, and nanobodies that bind nearly any biological target with nanomolar affinity?@MIT "BoltzGen: Toward Universal Binder Design" • Computational protein design methods have historically been limited to specific molecular classes
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Epigenetics Update - Deciphering histone mark-specific fine-scale chromatin organization at high resolution with Micro-C-ChIP https://t.co/B2XqNaf8ZU
#Epigenetics #Chromatin --- Discover the breakthrough at https://t.co/WmSYDGXnzb
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velotest: Statistical assessment of RNA velocity embeddings reveals quality differences for reliable trajectory visualizations https://t.co/wSZ8tpChsQ
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Congratulations to Huakun Zhang's group! #plantlncRNA
In vivo RNA structure influences the translation and stability of plant long noncoding RNAs #research #PlantCommunications
https://t.co/kzP7F9G3qD
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Big congratulations, Kelly!
Meet Kelly Nguyen, a 2025 #ListerPrize Fellow. She studies how telomerase works to maintain genome stability. Her top tip for researchers? "Be bold, and don’t let fear hold you back." 🔗 https://t.co/jloKiDwCW5 🔄 Repost to inspire others with her story @KellyTHD_Nguyen
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#Paper2Agent is highlighted by @AnthropicAI as one of the impactful partnerships using Claude! 🚀
We’re building tools to support research in the life sciences, from early discovery through to commercialization. With Claude for Life Sciences, we’ve added connectors to scientific tools, Skills, and new partnerships to make Claude more useful for scientific work.
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Missense variants in human forkhead transcription factors reveal determinants of forkhead DNA bispecificity
cell.com
Most forkhead (FH) transcription factors (TFs) recognize either FKH or FHL DNA binding site motifs, while some FHs bind both motifs. By screening a library of naturally occurring variants and...
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Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation https://t.co/fZpiOlTpUD
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Preprint from @GoogleDeepMind & @Yale Scaling Large Language Models for Next-Generation Single-Cell Analysis https://t.co/PxcX6YdyIp Cell2Sentence-Scale (C2S-Scale) is a 27 billion parameter foundation model that takes scRNA analyses to the next level 🤯 https://t.co/dYdMBLnrGN
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Large Language Models Meet Virtual Cell: A Survey 1. This comprehensive review explores how large language models (LLMs) are transforming cellular biology by enabling the development of “virtual cells” — computational systems that represent, predict, and reason about cellular
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