🧬 We are pleased to announce that, as part of our work with #HTAN, three new studies from our lab are published across the @Nature family! These studies offer insights into tumor biology, from spatial dynamics to chromatin accessibility in breast cancer.

Congratulations to Chia-Kuei (Simon) Mo, @ClaraLiu97, @IglesiaMichael, @reykajayasinghe, and many others! Special thanks to our collaborators, including @benjraphael and the dedicated investigators at @WashUOncology, for their invaluable contributions to this work! #HTAN

3️⃣ Inferring Tumor Phylogeography from Spatially Resolved Transcriptomics (@naturemethods): Introducing CalicoST, a method to map copy number aberrations across tumor regions, enabling high-resolution reconstructions of tumor evolution.

2️⃣ Breast Cancer Subtypes and Lineages Defined by Chromatin Accessibility (@NatureCancer): This study maps chromatin accessibility to reveal lineage-specific dynamics in #BreastCancer, advancing understanding of subtype pathways and therapeutic targets.

1️⃣ Tumor Evolution in 2D and 3D Microenvironments (@Nature): This study uncovers how tumor cells interact with surrounding stromal and immune cells to form distinct “tumor microregions”.

Researchers at WashU Medicine have created 3D maps of tumor structures, revealing how cancer cells and their environment are organized at a single-cell level. The study, published in Nature, could pave the way for innovative therapies. https://t.co/eyfht8czK0

Tumour atlases enable researchers to navigate through cancers

PRESS RELEASE: New insights from 10 Human Tumor Atlas Network studies provide critical information on how cancer tumors develop, spread, and respond to treatments. The research is to be published tomorrow in @NatureCancer. Learn more: https://t.co/dJWoONoI0M #CancerMoonshot #HTAN

A new study co-led by #WashUMed researchers analyzes the epigenomes of tumor cells across 11 cancer types, shedding light on the role of epigenetics in cancer formation, growth and spreading. Learn more:

Thank you to our many collaborators including Feng Chen, PhD @WUSTLmed; Ryan Fields, MD @WashUSurgery; and Ben Raphael , PhD @PrincetonCS—and to their dedicated teams. Additionally, we greatly appreciate the contributing members from @SitemanCenter, @BSC_CNS, and @UCSF_ObGynRS!

A special congratulations to co-first authors Nadya Terekhanova, PhD; Alla Karpova; and Wen-Wei Liang, PhD! @WUSTLmed

Excited to share that our most recent pan-cancer study is out in @Nature! We uncovered cis- and trans- epigenetic events linked to cancer initiation and progression across 11 cancer types. #PanCancer #HTAN #Epigenetics https://t.co/IUr8qKzN9b

Researchers at #WashUMed, @broadinstitute of @MIT and @Harvard, @BYU and more have completed an analysis of the proteins driving cancer across multiple tumor types. This raises the prospect of new therapies that block key proteins that drive cancer growth.

Today Cell, Cancer Cell and Cell Reports Medicine are pleased to publish the 1st wave of Pan-#Cancer multiomics papers looking at over 1000 patients across 10 #tumor types from @theNCI Clinical Proteomic Tumor Analysis Consortium #CPTAC (1/n) @Cancer_Cell @CellRepMed #openaccess

Data/Resources: Yongchao Dou, PhD, Bing Zhang,PhD @bcmhouston; Felipe Da Veiga Leprevost, PhD, Alexey Nesvizhskii, PhD @umichmedicine;Yifat Geffen, PhD Gad Getz, PhD @broadinstitute ; Anna Calinawan, Pei Wang, PhD @IcahnMountSinai ; Ana Robles, PhD @theNCI; Samuel Payne, PhD @BYU

PTM: Yifat Geffen, PhD, Shankara Anand, Yo Akiyama, Gad Getz, PhD @getz_lab @broadinstitute ; Tomer Yaron, PhD, Lewis Cantley, PhD @CantleyLab @harvardmed @DanaFarber

Driver: Eduard Porta-Pardo, PhD @BSC_CNS; Collin Tokheim, PhD @DanaFarber , Tomer Yaron, PhD, Lewis Cantley, PhD @CantleyLab @harvardmed @DanaFarber; Chandan Kumar-Sinha, PhD @umichmedicine ; Alexander Lazar, MD, PhD @MDAndersonNews ; Gad Getz, PhD @getz_lab @broadinstitute

#NCI #CPTAC is truly a multi-institutional effort. A special congratulations to all of our collaborators! Deep appreciation to Ana I. Robles, PhD and Henry Rodriguez, PhD, MBA @theNCI for their outstanding leadership in this effort! #TeamScience

Fernanda Martins Rodrigues; Nadezhda V. Terekhanova, PhD; Yige Wu, PhD; and Lijun Yao, PhD. Also extending acknowledgment to our @WUSTLmed collaborator, Milan Chheda, MD! #TeamScience

A big thank you and congratulations to all Ding Lab @theNCI #CPTAC contributors: Yize Li, PhD; Matt Bailey, PhD; Wen-Wei Liang, PhD; Yizhe Song; Rita Lu; Akshay Govindan; Reyka Jayasinghe, PhD; Matthew Wyczalkowski, PhD; Mike Wendl, PhD; Song Cao, PhD; Erik Storrs...