Deuerling Lab
@DeuerlingLab
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We are interested in understanding the basic principles of cellular proteostasis under normal, aging and disease conditions. Run by lab members. @UniKonstanz
Konstanz
Joined August 2022
Hi, I am Elke Deuerling. Great that our lab is now on Twitter. Our vision is to understand how cells stay fit and healthy and what happens during aging and disease. My great team will keep you updated with lots of interesting news from our lab.
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RT @UniKonstanz: How are proteins in our cells modified while they are still being synthesized? An international team of #UniKonstanz, @Cal….
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We are delighted to have been a part of this Story and want to thank our collaborators Shu-ou Shan at @Caltech and @The_Ban_Lab at @ETH_en for the awesome work we achieved together.
In our new study we reveal how NAC coordinates and regulates successive co-translational nascent chain ⛓️ processing on the mammalian ribosome.out today in @Nature collab with @DeuerlingLab Shu-ou Shan @Caltech.@snsf_ch @ERC_Research @ETH_en
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RT @The_Ban_Lab: In our new study we reveal how NAC coordinates and regulates successive co-translational nascent chain ⛓️ processing on th….
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Special thanks to our invited speakers: .@AG_Boettcher @StephanHacker2 @LabJoazeiro @KursadTurgay , Caroline Kisker, Jeff Kelly and Rick Morimoto.
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We very much enjoyed hosting the final SFB CRC969 Symposium in Konstanz. Thanks to all the speakers, poster presenters, and participants. It was great to see how amazing science, both chemistry and biology from @UniKonstanz, has shaped the understanding of #proteostasis.
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RT @TrendsBiochem: Available now - the Review "#Cotranslational sorting and processing of newly synthesized proteins in eukaryotes" from Ma….
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Time to say goodbye! .Megan from the @ASU got the @DAAD_Germany rise scholarship to work 2.5 month in our lab. She worked together with @DahlemCarla on the project of ribosome biogenesis in E.coli. We loved having you in the lab and hope to see you again in the future.
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RT @NatureSMB: Authors reveal architecture of the TRAP complex bound to the translating ribosome and Sec61 translocon, explaining its funct….
www.nature.com
Nature Structural & Molecular Biology - Here, the authors reveal the architecture of the TRAP complex bound to the translating ribosome and Sec61 translocon, explaining its function in...
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What an honor!.
EMBO announces the election of 69 new members and associate members who join the EMBO community of more than 2,000 leading life scientists in Europe and beyond.
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We are thrilled to announce that Elke was voted to be an #EMBO member. Thank you! What a great honor!.
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RT @The_Ban_Lab: Dynamic action of MetAP on the translating ribosome - new paper out in @ScienceMagazine from our beautiful collaboration w….
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@The_Ban_Lab It was a great to collaborate again with the brilliant people at @The_Ban_Lab @ETH_en Min Jia, @matjaskol and @skaiiol as well as @jomaa_lab and Kay Diederichs @UniKonstanz. Thank you to all of you! #ScienceResearch.
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Structural data by @The_Ban_Lab shows an active methionine excision complex of NAC and MetAP1 on a translating ribosome. This mode of interactions results in an efficient excision of methionine from soluble proteins, whereas proteins targeted to the ER are spared.
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Using purified components as well as C. elegans and cell culture mutants we show that NAC recruits MetAP1 to ribosomes for methionine cleavage via an interaction of a conserved hydrophobic motif in NACβ C-term and MetAP1 N-terminal zinc finger in vitro and in vivo.
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Check out our new study in @sciencemagazine. We show that NAC controls N-terminal methionine excision by MetAP1 in eukaryotes. Our results suggest a broader mechanism for how access of protein biogenesis factors to the translating ribosome is controlled.
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We had a great time at the #EMBOproteinQC workshop! .Thank you for the opportunity to give flashtalks and present our posters.
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RT @matjaskol: Dropping the anchor, how to TRAP a ribosome at the ER membrane! .Check out our new study describing a structure of TRAP comp….
www.nature.com
Nature Structural & Molecular Biology - Here, the authors reveal the architecture of the TRAP complex bound to the translating ribosome and Sec61 translocon, explaining its function in...
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