Joazeiro Lab
@LabJoazeiro
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πE3 Ubiquitin ligases and Protein Quality Control: mechanisms, functions and relevance for aging-related diseases, in particular neurodegeneration
Heidelberg, Germany
Joined May 2019
The Mother of All Ribosome Collisions Life before #ubiquitin: B. subtilis MutS2/RqcU senses translational stalls that lead to #ribosome collisions, then elicits degradation of the incomplete nascent-chains. Excited to share our findings, online @Nature today. #RQC
A team of researchers led by ZMBH's PIs C. Joazeiro @LabJoazeiro and S. Pfeffer @PfefferCryoLab discovered how the bacterial MutS2 protein prevents damage by stalled ribosomes! Further details in Nature
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With this new funding, weβre hiring PhDs and #postdocjobs Our #ERCAdG studies on the role of #RQC #ribosome #ubiquitin in #neurodegeneration will include using iPSCs, i-neurons, mammalian TC. The lab also has ongoing projects on #mitochondria and bacterial RQC.
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Thrilled and honored to receive the #ERCAdG! This will fund us for the next 5 yrs for groundbreaking research My project SuTra focuses on the Surveillance of Translation, from sensing #ribosome stalling to #RQC. We aim to learn how defective surveillance causes neurodegeneration
π£ Good news: 281 top researchers have just won ERC Advanced Grants! The new funding, worth nearly β¬721 million, is part of the πͺπΊ EUβs #HorizonEurope programme. Read more π https://t.co/62GOFDjQYq
#ERCAdG #FrontierResearch @EUScienceInnov
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Thanks, Ino! Thanks also to the LS1 panel for a constructive, fun interview! And congratulations to all fellow awardees! #ribosome #RQC #ubiquitin
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Thanks for your many contributions, Ivan. And of course, we would not have known about this amazing venue had you not pioneered meetings here.
Impressive #EMBOubiquitin24 in #Cavtat with more than 300 participants & active discussions at posters. Superb success- thx to the organisers @MerblYifat76992, @YKulathu, @LabJoazeiro, @polosimona1, @EMBOevents πππ«Άπ The hotel and weather matched the quality of science π β©
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Thanks, Shalini. Your talk was awesome!
Grateful to connect and learn from the great minds in ubiquitin, proteostasis and organelle quality control! Such a well-organised event! #EMBOubiquitin2024
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The credit to brilliant and fun thesis defense poster goes to Giuliano Arcaio
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Federico followed up on our discovery that bacteria also have an RQC pathway. In collab w @PfefferCryoLab, he elucidated mechanisms underlying Ala-tailing by RqcH (the homolog of Rqc2/NEMF), and discovered a factor that senses collided ribosomes upstream of RQC (hence, RqcU).
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Congratulations to my stellar (ex) PhD student Federico and all the awardees and honorable mentions for this achievement!
@huangkun1995 @EdinburghUni @irmantas_mogila @VU_LT @AtvuLsc @schulluc @mpi_marburg @maxplanckpress @ctstankey @Dr_James_Lee @crickinstitute @ToneyanSh @pkoo562 @CSHL @viennabiocenter honourable mentions: Christian Baca from @RockefellerUniv, Federico Cerullo from ZMBH Heidelberg (@UniHeidelberg), Pascal Devant from @Harvard, Leonard Ernst from @mpi_marburg @maxplanckpress 9/
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Donβt miss our next free virtual networking events in July! Will be fantastic βΊοΈ
Excited to announce our upcoming free virtual Networking events on 16th of July, 2024 with special guests joining for a fireside chat! This is a great opportunity to hear from and interact with trailblazers in the field and then network in smaller groups. Links below to sign-up
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Bacteria can counter noncanonical lipid ubiquitination with a #ubiquitin esterase! Fantastic collaboration with @ThurstonLab and @CMBI_Szczesna, with @r_lacoursiere driving our side of the project using some amazing tools built by the Geurink lab.
Excited to share our preprint on how a cytosolic bacteria evades LPS ubiquitylation and antibacterial autophagy through an effector with esterase activity. Led by @CMBI_Szczesna in the lab @ImperialInfect @CBRB_Imperial with superb collaborator @jnpruneda
https://t.co/jvXqxWBMFu
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#CryoEM staff scientist position with awesome PI, doing exciting research, in great place. Apply! π¨ππ¨ππ¨π
π¬ Join us at EPFL's School of Life Sciences as a Staff Scientist Expert in Cryo-EM! Work with cutting-edge facilities, collaborate with top researchers, and drive groundbreaking discoveries in structural biology. Apply now: https://t.co/pn5k7nCjHB
#ScienceJobsΒ #CryoEMΒ #EPFL
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Check out our new preprint: https://t.co/RJVzfuzVgY A fantastic team effort, thanks to Jonas Duering + Madita Wolter, and our spectacular collaborators. Massive thanks to all the people involved in this work!
researchsquare.com
Ubiquitin ligases (E3s) are pivotal specificity determinants in the ubiquitin system by selecting substrates and decorating them with distinct ubiquitin signals. Structure determination of the...
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Excited to share the final product of this work, now available at @MolecularCell. Extremely proud of @tylergfranklin for this and many other achievements during his thesis work! https://t.co/rpp6LOfeK3
What can bacteria teach us about #ubiquitin? A lot! In our latest preprint, @tylergfranklin set out to understand how secreted bacterial ligases catalyze ubiquitin modifications during infection. What he found will surprise you! https://t.co/IlOCPeg1uH
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re-tweeting announcement with fixed typo
With a fixed typo, I re-invite you to come chat Ub & Targeted Protein Degradation with our welcoming community at the @FASEBorg #UBPSRC where full days of exciting science with joyful interactions will be capped by nightly fireworks over the natural wonder of Niagara Falls.
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We're excited with our line up of speakers for the FASEB #Ubiquitin meeting in June 2024! Join us in Niagara Falls to hear stories ranging from ubiquitin signaling and mechanisms to #RQC and targeted protein degradation (#TPD #protacs #molecularglues)
Please join us this summer as the power of Ubiquitin Signaling converges with the power of Niagara Falls for @FASEBorg #UBPSRC. We value DEIA, are raising $ for travel awards, have fantastic speakers and are excited to select new speakers from abstracts. @LabJoazeiro
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New work from the lab @NatureAging! π±π± We asked whether the ability of plants to suppress pathological protein aggregation can be applied into human cell and animal models to delay or even prevent neurodegenerative diseases https://t.co/yd2VDHYMjz
nature.com
Nature Aging - Unlike animals, plants prevent pathological polyQ aggregation through chloroplast proteostasis. Expression of the chloroplast protein SSP in human cell and nematode models prevents...
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(2/2) RA: https://t.co/gsQ9DRWUEc Staff scientist: https://t.co/6LBhqxOxjL
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