Joazeiro Lab
@LabJoazeiro
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💙E3 Ubiquitin ligases and Protein Quality Control: mechanisms, functions and relevance for aging-related diseases, in particular neurodegeneration
Heidelberg, Germany
Joined May 2019
The Mother of All Ribosome Collisions.Life before #ubiquitin: B. subtilis MutS2/RqcU senses translational stalls that lead to #ribosome collisions, then elicits degradation of the incomplete nascent-chains. Excited to share our findings, online @Nature today. #RQC.
A team of researchers led by ZMBH's PIs C. Joazeiro @LabJoazeiro and S. Pfeffer @PfefferCryoLab discovered how the bacterial MutS2 protein prevents damage by stalled ribosomes! Further details in Nature
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With this new funding, we’re hiring PhDs and #postdocjobs. Our #ERCAdG studies on the role of #RQC #ribosome #ubiquitin in #neurodegeneration will include using iPSCs, i-neurons, mammalian TC. The lab also has ongoing projects on #mitochondria and bacterial RQC.
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Thrilled and honored to receive the #ERCAdG! This will fund us for the next 5 yrs for groundbreaking research. My project SuTra focuses on the Surveillance of Translation, from sensing #ribosome stalling to #RQC. We aim to learn how defective surveillance causes neurodegeneration.
📣 Good news: 281 top researchers have just won ERC Advanced Grants!. The new funding, worth nearly €721 million, is part of the 🇪🇺 EU’s #HorizonEurope programme. Read more 👉 . #ERCAdG #FrontierResearch @EUScienceInnov
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Thanks, Ino! Thanks also to the LS1 panel for a constructive, fun interview! And congratulations to all fellow awardees! #ribosome #RQC #ubiquitin
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Thanks for your many contributions, Ivan. And of course, we would not have known about this amazing venue had you not pioneered meetings here.
Impressive #EMBOubiquitin24 in #Cavtat with more than 300 participants & active discussions at posters. Superb success- thx to the organisers @MerblYifat76992, @YKulathu, @LabJoazeiro, @polosimona1, @EMBOevents 🙌👏🫶👍.The hotel and weather matched the quality of science 😊.
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Thanks, Shalini. Your talk was awesome!.
Grateful to connect and learn from the great minds in ubiquitin, proteostasis and organelle quality control! Such a well-organised event! #EMBOubiquitin2024
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The credit to brilliant and fun thesis defense poster goes to Giuliano Arcaio.
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Federico followed up on our discovery that bacteria also have an RQC pathway. In collab w @PfefferCryoLab, he elucidated mechanisms underlying Ala-tailing by RqcH (the homolog of Rqc2/NEMF), and discovered a factor that senses collided ribosomes upstream of RQC (hence, RqcU).
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Congratulations to my stellar (ex) PhD student Federico and all the awardees and honorable mentions for this achievement!.
@huangkun1995 @EdinburghUni @irmantas_mogila @VU_LT @AtvuLsc @schulluc @mpi_marburg @maxplanckpress @ctstankey @Dr_James_Lee @crickinstitute @ToneyanSh @pkoo562 @CSHL @viennabiocenter honourable mentions: Christian Baca from @RockefellerUniv, Federico Cerullo from ZMBH Heidelberg (@UniHeidelberg), Pascal Devant from @Harvard, Leonard Ernst from @mpi_marburg @maxplanckpress 9/.
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RT @danetteldaniels: Don’t miss our next free virtual networking events in July! Will be fantastic ☺️.
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RT @jnpruneda: Bacteria can counter noncanonical lipid ubiquitination with a #ubiquitin esterase! Fantastic collaboration with @ThurstonLa….
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#CryoEM staff scientist position with awesome PI, doing exciting research, in great place. Apply! 🇨🇭🇨🇭🇨🇭.
🔬 Join us at EPFL's School of Life Sciences as a Staff Scientist Expert in Cryo-EM! Work with cutting-edge facilities, collaborate with top researchers, and drive groundbreaking discoveries in structural biology. Apply now: #ScienceJobs #CryoEM #EPFL.
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RT @SLorenzLab: Check out our new preprint: .A fantastic team effort, thanks to Jonas Duering + Madita Wolter, and….
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RT @jnpruneda: Excited to share the final product of this work, now available at @MolecularCell. Extremely proud of @tylergfranklin for thi….
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re-tweeting announcement with fixed typo.
With a fixed typo, I re-invite you to come chat Ub & Targeted Protein Degradation with our welcoming community at the @FASEBorg #UBPSRC where full days of exciting science with joyful interactions will be capped by nightly fireworks over the natural wonder of Niagara Falls.
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We're excited with our line up of speakers for the FASEB #Ubiquitin meeting in June 2024! Join us in Niagara Falls to hear stories ranging from ubiquitin signaling and mechanisms to #RQC and targeted protein degradation (#TPD #protacs #molecularglues).
Please join us this summer as the power of Ubiquitin Signaling converges with the power of Niagara Falls for @FASEBorg #UBPSRC. We value DEIA, are raising $ for travel awards, have fantastic speakers and are excited to select new speakers from abstracts. @LabJoazeiro
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RT @TheVilchezLab: New work from the lab @NatureAging! 🌱🌱 We asked whether the ability of plants to suppress pathological protein aggregati….
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We're hiring! Our lab branch at UF Scripps, West Palm Beach, Florida, has an opening for a Research Assistant or Staff Scientist position 🌞😎🏖️🧪🧠. If you're interested in studying molecular mechanisms of neurodegeneration using mammalian cells and mouse models, apply! (1/2).
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Enhorabuena, Carlos! Two papers in one week!.
Our new follow-up on GAP43-CB1R complexes. Kudos to @MarotoIrene @Moreno_G_Estefa and the rest of the teams @leyreuriguen @BBM_UCM @UniBarcelona @unicomplutense .
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