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Stephan Hacker (inactive account) Profile
Stephan Hacker (inactive account)

@StephanHacker2

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Inactive account. Find me at: @stephanhacker2.bsky.social @[email protected] https://t.co/kPr9QkAN2S

Leiden, The Netherlands
Joined July 2018
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
Due to recent developments with this platform, I have decided to inactivate this account. I will for now keep it open and will not delete the content, but I will not post here anymore. Find me at:.@Stephanhacker2@mstdn.science.@stephanhacker2.bsky.social.
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
Interesting paper by the groups of Jean-Marie Lehn and Oleksandr Koniev in @J_A_C_S. They developed 6-fluorosalicylaldehydes into tools that initially form imines with lysines. This activates them for irreversible modification of cysteines via SNAr.
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
Apparently the same for a lot of German universities leaving. #WissXit (Article in German).
@StephanHacker2
Stephan Hacker (inactive account)
6 months
Very interesting development that the Dutch research funding organization @NWONieuws is quitting twitter. It might be time to consider doing the same. I hope to find them back at one of the other platforms in addition to LinkedIn.
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
Very interesting development that the Dutch research funding organization @NWONieuws is quitting twitter. It might be time to consider doing the same. I hope to find them back at one of the other platforms in addition to LinkedIn.
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
If you are looking for exciting scientific content (with a focus on #ChemBio, #Chemistry, #ABPP, #ChemicalProteomics) over on the other platform, check out these starter packs:.short list: pack 1: pack 2:
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
Very interesting paper by the groups of @CossarPeter and Luc Brunsveld in @ChemicalScience. An exciting chemical crosslinker that reacts with a cysteine and a histidine to identify interactions of 14-3-3 with intrinsically disordered proteins.
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
Very excited to see what is coming for DIA-NN 2.0.
@DemichevLab
Vadim Demichev
6 months
DIA-NN 2.0 release is almost ready, will come with some big news. One is scanning methods support, at the moment doing some tuning of the algorithm using Synchro-PASEF data by @labs_mann :) Turns out, 'Q1 information' is really helpful for gaining peptidoform confidence. Likely.
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
RT @DemichevLab: DIA-NN 2.0 release is almost ready, will come with some big news. One is scanning methods support, at the moment doing somโ€ฆ.
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
If you are interested in ๐—”๐—ฐ๐˜๐—ถ๐˜ƒ๐—ถ๐˜๐˜†-๐—•๐—ฎ๐˜€๐—ฒ๐—ฑ ๐—ฃ๐—ฟ๐—ผ๐˜๐—ฒ๐—ถ๐—ป ๐—ฃ๐—ฟ๐—ผ๐—ณ๐—ถ๐—น๐—ถ๐—ป๐—ด, definitely consider the #ABPP2025 conference @abpp2025london on March 30th to April 2nd, 2025, at The Francis Crick Institute. Registration deadlines have been updated.
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
An interesting short read by @drughunter_com on the kinetics of reversible and irreversible covalent inhibitors including some examples from the industry. It includes links for more in-depth reading.
@drughunter_com
drug hunter
6 months
This Covalent Enzyme Cheat Sheet provides real-world examples to clarify the mechanisms and terminology used in assessing the potency of covalent and non-covalent enzyme inhibitors. Link:
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
RT @drughunter_com: This Covalent Enzyme Cheat Sheet provides real-world examples to clarify the mechanisms and terminology used in assessiโ€ฆ.
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
RT @mbogyo: Just got started on BlueSky Social. Come follow me there. @mbogyo.bsky.social.
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
Exciting paper by the groups of Ronald Micura and Alexandra Lusser in @nchembio. Covalent binders to structured RNA based on alkyl halides and alkyl mesylates show engagement of the preQ1 and Pepper aptamers in vitro and in cells.
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
Interesting paper by a team around Gerald Schweiger in @PNASNews. Interesting insights into the benefits, disadvantages and costs of competitive research funding. Especially interesting to see how much we do not know, about such an important system.
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
Great to see the 3 final nominees for the "Teacher of the Year Award" of our Faculty @LeidenScience, Joost Willemse (IBL), Sander van Kasteren (LIC) and Rob van Wijk (LACDR), being recognized at the New Year's Reception. Huge caongratulations to Rob van Wijk on winning the award!
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
RT @LED3hub: LED3 hub member Mario van der Stelt represented our network with a great Tuesday Talk at the New Year's Reception of our Faculโ€ฆ.
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
Great Tuesday Talk by Mario van der Stelt at the New Year's Reception of the Faculty of Science @LeidenScienceEN. He talked about his research in the context of the @LED3hub on (endo)cannabinoids and their functions in the brain.
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
RT @LED3hub: The @LED3hub is very excited to be a key part of the research theme "Drug Disovery and Development" that was together with theโ€ฆ.
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
The year officially opens at our Science Faculty @LeidenScience. Great to hear our dean Jasper Knoester talk about the highlights of the last year, about the plans for the next, about the power of connections and about the six themes, including @LED3hub, as an important priority.
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@StephanHacker2
Stephan Hacker (inactive account)
6 months
Join us in Leiden for this exciting meeting on "Drug Discovery and Global Health" organized by @LED3hub and LUCID. Free registration is required.
@LED3hub
LED3 hub (inactive account)
6 months
We are very excited to announce the @LED3hub & LUCID Symposium "Drug Discovery and Global Health" on February 6th with keynotes @Kelly_Chibale and Paola Picotti @Picotti_Lab as well as an amazing lineup of further speakers. Free registration is required.
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