Stephan Hacker (inactive account)
@StephanHacker2
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Inactive account. Find me at: @stephanhacker2.bsky.social @[email protected] https://t.co/kPr9QkAN2S
Leiden, The Netherlands
Joined July 2018
Due to recent developments with this platform, I have decided to inactivate this account. I will for now keep it open and will not delete the content, but I will not post here anymore. Find me at:.@Stephanhacker2@mstdn.science.@stephanhacker2.bsky.social.
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Interesting paper by the groups of Jean-Marie Lehn and Oleksandr Koniev in @J_A_C_S. They developed 6-fluorosalicylaldehydes into tools that initially form imines with lysines. This activates them for irreversible modification of cysteines via SNAr.
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Apparently the same for a lot of German universities leaving. #WissXit (Article in German).
Very interesting development that the Dutch research funding organization @NWONieuws is quitting twitter. It might be time to consider doing the same. I hope to find them back at one of the other platforms in addition to LinkedIn.
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Very interesting development that the Dutch research funding organization @NWONieuws is quitting twitter. It might be time to consider doing the same. I hope to find them back at one of the other platforms in addition to LinkedIn.
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If you are looking for exciting scientific content (with a focus on #ChemBio, #Chemistry, #ABPP, #ChemicalProteomics) over on the other platform, check out these starter packs:.short list: pack 1: pack 2:
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Very interesting paper by the groups of @CossarPeter and Luc Brunsveld in @ChemicalScience. An exciting chemical crosslinker that reacts with a cysteine and a histidine to identify interactions of 14-3-3 with intrinsically disordered proteins.
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Very excited to see what is coming for DIA-NN 2.0.
DIA-NN 2.0 release is almost ready, will come with some big news. One is scanning methods support, at the moment doing some tuning of the algorithm using Synchro-PASEF data by @labs_mann :) Turns out, 'Q1 information' is really helpful for gaining peptidoform confidence. Likely.
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RT @DemichevLab: DIA-NN 2.0 release is almost ready, will come with some big news. One is scanning methods support, at the moment doing somโฆ.
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If you are interested in ๐๐ฐ๐๐ถ๐๐ถ๐๐-๐๐ฎ๐๐ฒ๐ฑ ๐ฃ๐ฟ๐ผ๐๐ฒ๐ถ๐ป ๐ฃ๐ฟ๐ผ๐ณ๐ถ๐น๐ถ๐ป๐ด, definitely consider the #ABPP2025 conference @abpp2025london on March 30th to April 2nd, 2025, at The Francis Crick Institute. Registration deadlines have been updated.
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An interesting short read by @drughunter_com on the kinetics of reversible and irreversible covalent inhibitors including some examples from the industry. It includes links for more in-depth reading.
This Covalent Enzyme Cheat Sheet provides real-world examples to clarify the mechanisms and terminology used in assessing the potency of covalent and non-covalent enzyme inhibitors. Link:
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RT @drughunter_com: This Covalent Enzyme Cheat Sheet provides real-world examples to clarify the mechanisms and terminology used in assessiโฆ.
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Exciting paper by the groups of Ronald Micura and Alexandra Lusser in @nchembio. Covalent binders to structured RNA based on alkyl halides and alkyl mesylates show engagement of the preQ1 and Pepper aptamers in vitro and in cells.
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Interesting paper by a team around Gerald Schweiger in @PNASNews. Interesting insights into the benefits, disadvantages and costs of competitive research funding. Especially interesting to see how much we do not know, about such an important system.
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Great to see the 3 final nominees for the "Teacher of the Year Award" of our Faculty @LeidenScience, Joost Willemse (IBL), Sander van Kasteren (LIC) and Rob van Wijk (LACDR), being recognized at the New Year's Reception. Huge caongratulations to Rob van Wijk on winning the award!
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RT @LED3hub: LED3 hub member Mario van der Stelt represented our network with a great Tuesday Talk at the New Year's Reception of our Faculโฆ.
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Great Tuesday Talk by Mario van der Stelt at the New Year's Reception of the Faculty of Science @LeidenScienceEN. He talked about his research in the context of the @LED3hub on (endo)cannabinoids and their functions in the brain.
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The year officially opens at our Science Faculty @LeidenScience. Great to hear our dean Jasper Knoester talk about the highlights of the last year, about the plans for the next, about the power of connections and about the six themes, including @LED3hub, as an important priority.
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Join us in Leiden for this exciting meeting on "Drug Discovery and Global Health" organized by @LED3hub and LUCID. Free registration is required.
We are very excited to announce the @LED3hub & LUCID Symposium "Drug Discovery and Global Health" on February 6th with keynotes @Kelly_Chibale and Paola Picotti @Picotti_Lab as well as an amazing lineup of further speakers. Free registration is required.
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