The Ban Lab
@The_Ban_Lab
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Joined April 2018
New paper out in Mol Cell, where we show how N-myristolytransferases lipidate proteins on the translating ribosome! Continuing our successful collaboration with @DeuerlingLab & Shu-ou Shan @Caltech
@snsf_ch @ETH_en
https://t.co/TTGrslPSFp
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Nice collaboration with the Gatfield lab, providing new insights into the regulation of reinitiation on human mRNAs: https://t.co/Fp2RpJyRyG
embopress.org
imageimageThis study explores the mechanisms of ribosome re-initiation after upstream open reading frame (uORF) translation, uncovering distinct roles for MCTS1-DENR and eIF2D. A novel cell-free...
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In our new study we reveal how NAC coordinates and regulates successive co-translational nascent chain ⛓️ processing on the mammalian ribosome out today in @Nature
https://t.co/KXdYY1ZVHA collab with @DeuerlingLab Shu-ou Shan @Caltech
@snsf_ch @ERC_Research @ETH_en
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New job opportunity in the Ban Lab: experimental biochemist 🧑🔬 with a Master’s or a PhD degree to support lab operations. For more info see:
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Preprint Gatfield lab,@The_Ban_Lab& @TelemanLab w/ 1st author Romane Meurs "An in vitro assay of MCTS1-DENR-dependent re-initiation & ribosome profiling uncover the activity of MCTS2 and distinct function of eIF2D" https://t.co/ZVGKIbVDbr
@nairda_b @cig_unil @unil @ETH_en @DKFZ
biorxiv.org
Ribosomes scanning from the mRNA 5′ cap to the start codon may initiate at upstream open reading frames (uORFs), decreasing protein biosynthesis. Termination at a uORF can lead to re-initiation,...
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Check out our new paper on the architecture and subunit composition of the human pyruvate dehydrogenase complex which just appeared in Science Advances. Many thanks to all who contributed to this terrific collaboration! https://t.co/1oE4C3QWUa
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Unique architectural features of mammalian mitochondrial protein synthesis 30-day free access to our new review at: https://t.co/Mbsbic4SfK Thanks to all the authors for their insightful contributions and our editor for their kind invitation and guidance.
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Publication by the @The_Ban_Lab (@ETH_en) with 1st author Adrian Bothe (@nairda_b) "A highly optimized human in vitro translation system" @CellRepMethods
https://t.co/GoI7edbhv5
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Congratulations to Prof. Nenad Ban (IMBB) from our department on being appointed as a member of the American Academy of Arts and Sciences @americanacad! A well deserved honor! https://t.co/mGVo1Lwy1v
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Nenad Ban has been elected as a Member of the American Academy of Arts & Sciences(@americanacad)! Congratulations!!! https://t.co/aEmvisl4GX
@The_Ban_Lab @ETH_DBIOL @ETH_en
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New resources for nomenclature of ribosomal proteins! 🍀 NEW: plant cytosolic ribosomes 🧬 PyMOL sessions and -scripts for cytosolic, mitochondrial and chloroplast ribosomes 🗂️ Updated tables for nomenclature of paralogues accessible on our website: 🔗 https://t.co/ECvRmXCZjK
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New in @CellRepMethods from @nairda_b, and team at @The_Ban_Lab: “A highly optimized human in vitro translation system.” Thank you for choosing Twist DNA to support your work! 🧬 https://t.co/MFb8ZFiIs0
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A highly optimized human in vitro translation system
cell.com
Bothe and Ban optimize a human cell-based in vitro translation system, which can be used to produce proteins in a cell-free way from purified mRNA in a test tube. Through systematic screening of...
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We have optimized a human in-vitro translation system (HITS) for use in #ribosome research Our HITS: 🧪requires a minimal number of components 💵is cheap & easy to prepare 💡enables cap-dependent translation 📈is highly active online now: https://t.co/h9pnqXkGgS
@CellRepMethods
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Review by @The_Ban_Lab (@ETH_DBIOL, @ETH_en) & Karousis Lab (@RNAkook, @DCBPunibern, @unibern on "#Coronavirus takeover of #host cell #translation and intracellular antiviral response: a molecular perspective" @embojournal @KathaSchubert
https://t.co/ZozwJdSb16
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The pyruvate dehydrogenase complex is one of the largest protein complexes known and a key metabolic mega-enzyme. Check out our paper on the mechanism behind its architecture just published in Science Advances:
science.org
Dimerization of a small domain solves the 60-year-old conundrum of the assembly of a key metabolic megaenzyme.
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We are happy and proud to present a molecular movie of our current understanding of co-translational protein processing and ER targeting in mammalian cells, summarising decade-long research. Subscribe for updates! https://t.co/vrNjmyuyRV
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One more in our RNA review series! @The_Ban_Lab discuss the unique molecular features of coronaviruses that enable them to commandeer host cell mRNA translation while avoiding intracellular immune defense responses https://t.co/pj5YT4DkkL
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