Sihan Wu 吴思涵
@SihanSean
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Assistant Professor @CRI_UTSW, @UTSWCancerBio @GDDgradprogUTSW @utswcancer member. CPRIT scholar @CPRITTexas. Ph.D. Molecular basis of ecDNA in human cancer.
Dallas, TX
Joined March 2019
ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment https://t.co/UcD3xDQXdL
#biorxiv_cancer
biorxiv.org
ecDNA contributes to cancer genetic heterogeneity through random segregation during mitosis. Emerging evidence links ecDNA to immune evasion, but the mechanism remains elusive. Using genetically...
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Wonderful conference organized by @zz_zhaozhang @regenberg_lab @Fusion_Conf. Congrats to @stanleylim93 for the #1 best poster. And PI got awarded for his nosiness on other people’s research. Photo credits to @PeterLyLab
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I don't understand...Cancer researchers again need to pay to access the knowledge they create.
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Very proud to contribute! Emerging evidence links ecDNA with cold TME. But still chicken&egg as we don't know the mechanism yet. Stay tuned for new findings to come.
From the June issue: Spatial-Temporal Diversity of #ecDNA Shapes Urothelial Carcinoma Evolution & Tumor-Immune Microenvironment https://t.co/Bz5XIj6fKZ By Wei Lv, Yuchen Zeng, Conghui Li, Yuan Liang, Birgitte Regenberg, Yonglun Luo, Chunhua Lin, Peng Han, and colleagues
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Accurate Prediction of ecDNA in Interphase Cancer Cells using Deep Neural Networks https://t.co/STFWBIepS1
#biorxiv_cancer
biorxiv.org
Oncogene amplification is a key driver of cancer pathogenesis and is often mediated by extrachromosomal DNA (ecDNA). EcDNA amplifications are associated with increased pathogenicity of cancer and...
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Wu lab is 4 years old! Had our anniversary feast today at Dong Bo Sung (again! cause its good!) and 🎂 cake from Ecclesia Bakery @SihanSean @YoonKimUTSW @QK15622518 @LucasaEast @Burg1ess @yipengxie_utsw
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🎉 Exciting News! 🎉 Registration grants have been released to support ECR's attending #ecDNA25! Don't miss the chance to engage with cutting-edge research & connect with experts in the field.🌟Find out more: https://t.co/7jjRcwxae4
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📢 [Live Webinar] Modern Biology of ecDNA in Cancer Through the Lens of #3DGenomics with Dr. @SihanSean Discover how 3D genomic technologies are transforming our understanding of #ecDNA in small cell lung cancer (SCLC). Plus, learn how ecDNA drives tumor evolution, therapy
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Happy International Women’s Day! We’re celebrating women who have changed the world. Here are all of the amazing women who have received the #NobelPrize and their remarkable achievements at the time of the award. Tell us about the women who inspire you the most - and why
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I will present our lab's most recent research. Look forward to meeting new collaborators and friends!
🧬🌟We're excited to add an Extrachromosomal Circular DNA conference to our 2025 calendar!🧬🌟 Chairs Birgitte Regenberg (Univ. of Copenhagen) & Zhao Zhang (Duke Univ.) are bringing a fantastic line up of speakers together in Mexico this November. More
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And here is a sneak peek of what is happening in the Wu lab.
Transcription Machinery Anchors ecDNAs to Mitotic Chromosomes for Segregation https://t.co/tYTkeC9fRK
#biorxiv_cancer
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🥳Review paper online: Modern biology of extrachromosomal DNA: A decade-long voyage of discovery👏You'll find modern ecDNA biology uncovered over the last ten years👍Kudos to my trainees who put everything together❤️Thank @CancerGrand for support! https://t.co/iqPn8NbK55
nature.com
Cell Research - Modern biology of extrachromosomal DNA: A decade-long voyage of discovery
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I love my LEGO! Luckily no one stole it. And y'all need to do push up everyday. Don't let your not-young-any-more PI beat you up on sports.
White elephant gift exchange today for @SihanSean lab with X'mas cake from Paris Baguette! Post-party lab dinner at Ngon Vietnamese Kitchen for Pho and Papaya Salad with Beef Jerky (unexpectedly good combination🤤)! Happy holidays everyone!! @YoonKimUTSW @Burg1ess @yipengxie_utsw
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White elephant gift exchange today for @SihanSean lab with X'mas cake from Paris Baguette! Post-party lab dinner at Ngon Vietnamese Kitchen for Pho and Papaya Salad with Beef Jerky (unexpectedly good combination🤤)! Happy holidays everyone!! @YoonKimUTSW @Burg1ess @yipengxie_utsw
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I shared our protocol for doing FISH on FFPE with many labs before. Then I realized, why not publish it to make it more accessible to everyone? My lab manager, Collin, is the master of this technique and makes it work every single time.
OUT NOW in @JoVEJournal: 📺Watch this optimized technique, suitable for clinical FFPE samples, to detect amplified genes developed in CRI's @SihanSean Lab #relentlessdiscovery
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October lab dinner is spicy mala food at Sichuan Folk! Mapo tofu is my must-order food as always. Also good pairing with Mango Creme Brulee Cake from 85°C Bakery for the October birthday!! @SihanSean @LucasaEast @Burg1ess @yipengxie_utsw
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Another reason why you should apply to the Forbeck forum. The best filet mignon so far. Not to mention the three perfectly paired wines. Well I do learn a lot from my fellow scientists today by the way.
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Can't believe this is my last year to attend the Forbeck Scholar Retreat. 3 years just seemed so short. I will remember all the great science and intensive discussions. I will present on Saturday, and the project's idea was born during my first Forbeck retreat. @ForbeckForums
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Thumbs up to the pork chop and deviled eggs👍The best so far
September lab dinner is Whiskey Cake! Appetizers and mains were delicious, especially Deviled Eggs and Bone-in Pork Chop (soft and full of flavor), and of course those Whiskey Cakes 🍰 for sweet tooth peeps @SihanSean @YoonKimUTSW @QK15622518 @LucasaEast @Burg1ess @yipengxie_utsw
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