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Seed oils are cardioprotective. They reduce Cardiovascular morality and event rates. The seed oil crowd likes to quote one single rest study from 1956. We have 67 more years data on actual humans. Not rats. Humans. Let's stop denying science. Please quote one single human trial
How about we look at every study that's ever been done on LDL-Cholesterol? With 20 million person years of follow up? Enough nonsense. If you don't know, just stop with the nonsense. It's not a "gut feeling", or "I think". We have the data. As
@BioLayne
always says,
Your liver is not happy because, calorie for calorie, saturated fat increases fatty liver more then any other macronutrient. Your heart, brain, and kidneys aren't happy because Saturated fat also increases your LDL-C and plugs up your arteries in all your organs giving you
There are 120 grams of protein on this board. My kidneys are very happy. My heart is very happy. My liver is very happy. My brain is very happy. Big Pharma and Big Food are NOT happy.
The idiocy continues. Seed oils have been studied in humans. We have studies with 68k participants that were followed for 31.9 years that had 76k tissue biopsies and the endpoints were reached 15k times. Seed oils were cardioprotective. Enough with the nonsense. This just proves
Saying it’s ‘organic’ doesn’t make up for
the fact that the number one ingredient is
pro inflammatory processed seed oils.
That makes it processed junk food in my book.
I’ll skip it for health reasons.
A meta-analysis of 46 observational studies evaluating the association between statin therapy and the incidence of neuro-cognitive diseases showed that the use of statins not only did not increase the risk of f neurocognitive disorders, but rather was associated with a
Life Hack:
Eat more butter.
43.0% of the U.S. population is deficient in vitamin A, 94.3% in vitamin D, and 88.5% in vitamin E.
All found in our favorite animal fat:
Layne is right. We have studies with 68,000 participants, with 76,000 tissue biopsies, and where the endpoints were met 15,000 times. Seed oils are cardioprotective. This nonsense needs to end. You don't have to consume them if you don't want to but you can't really argue with
Just invoking ‘SEED OILS’ means fuck all. I look at the data. I don’t give a shit how popular it is to demonize a particular ingredient
I wish the data said they were bad for you. Would make my life much more pleasant and less filled with imbeciles
Supplements do not lower cholesterol, LDL-C, apoB.
The Cleveland Clinic did such a study on supplements that were thought to lower cholesterol. They were all third party tested and were used at doses that were thought to be effective. It was prospective and placebo controlled.
We are trying to lower cholesterol because it's the cause of ASCVD. Your body isn't that smart. Humans used to live to 35 when we "let the body self regulate". My goodness. Stop the nonsense.
Why are we still trying to blindly lower cholesterol/LDL?
I trust my body that it knows what it needs & how to regulate it. My body makes most of the cholesterol & recycles it for a reason.
The fact that statins have so many side effects, tells us how dumb we are to interfere.
It's fine to eat cereal. What the heck is going on here? Eat within your caloric limits and enjoy life. Stay lean and fit and eat an overall healthy eating patterns. We don't need to demonize entire food groups. Food doesn't contain inherent morality. Food is just food. If you
Because 88% of U.S. Adults have at least one marker of metabolic disease and you, a "trusted" source of nutrition information as saying it's ok to eat a bowl of sugar/starch. That's why...
I don’t trust doctors or dietitians who tell you that red meat 🥩 is bad for your health. They already lost any credibility because they failed the test of common sense.
Ancient food cannot be responsible for modern diseases. You cannot find more nutrient dense food than meat.
People who improved their diabetes and hypertension by reducing caloric intake while still eating lots of carbs are everywhere. The world doesn't revolve around Keto.
Where are all the people who reversed their type 2 diabetes and hypertension and came off medications by cutting calories without reducing carbohydrates?
Where are all the people who are putting their autoimmune diseases and chronic pain in remission while eating “everything in
High and low LDL-C increases mortality? Looking at 4 million veterans and correcting for confounders, covariates, and reverse causality correctly actually shows that the lower the LDL-C, the lower the morality. And the lower, the better! Simple.
None of these are human outcome trials. Rat studies, test tube studies, petri dish studies don't beat human studies.
The largest study ever done on "seed oils" (linoleic acid) was published in Circulation. They looked at 68k people for 31.9 years, where the endpoints were reached
@hubermanlab
@BioLayne
There are multiple controlled trials in humans, many of which are randomized, showing significant negative effects of increasing dietary PUFA.
PMID: 8432867 - Increased LDL oxidation from increased dietary LA
PMID: 2008870 & 10452406 - More PUFA = higher lipid peroxidation.
Cardiologist: Don't just do Cardio! Please pick up heavy things too!
According to a study, weightlifting can reduce the risk of all-cause mortality by 9%. A meta-analysis of 11 studies found that resistance training alone reduced all-cause mortality by 21%, and when combined
In case we needed more evidence in 2024.
"The Importance of LDL-C Lowering in Atherosclerotic Cardiovascular Disease Prevention: Lower for Longer is Better"
Statins don't "cause" diabetes. In some people who already have insulin resistance or diabetes, there's a 0.1% increase in A1c which could put them over the edge to becoming "diabetic". I'm not sure why you think this will upset people. If a last person sees this, you are just
🔥Let’s piss off dogmatic doctors, today I choose violence
Statins cause diabetes
Statins cause diabetes
Statins cause diabetes
Statins cause diabetes
Statins cause diabetes
Statins cause diabetes
Statins cause diabetes
Statins cause diabetes
Statins cause diabetes
Recent study on
#LMHR
and
#CAC
showed no worsening of CAC scores. This is a very flawed way to evaluate young healthy people for ASCVD on a ketogenic diet. Firstly, CAC is a late stage finding and takes decades to become positive. Looking at CAC after 4 years isn't helpful. It
Why doesn't
#ASCVD
happen in veins? Why only arteries? Is it endothelial damage? Inflammation? Pressure? Twists and turns? More kinks? Those may all contribute. But it's RETENTION. Arteries can retain
#ApoB
! All LDL are small enough to cross. Great study that tested all this.
In my opinion it's clear that LDL
- does not itself cause CVD
- in CVD plays an immunological role, aiding with (but not causing the need for) scarring
- in the LMHR is not immunological but a marker and result of low energy availability (other than through VLDL and glucose).
1/
Jillian: Don't take proven medications for weight loss!
Me: Why not?
Jillian: Buy my nonsense supplements instead.
🤦🏻
People who have no idea what they are talking about should probably stop talking about things they know nothing about.
GLP1RAs help with:
✅ Diabetes
✅
Very important study on reverse causality with 4.5 million participants. Low LDL-C doesn't increase mortality. People with end stage nutrition, cancer, COPD, heart disease have lower LDL-C. And are usually on lipids lowering therapy at this stage.
🔥 We know keto and fasting can reduce inflammation and its ability to do so is multifaceted. Ketones are a big player, though, because they can actually interact with receptors in our cells to signal for different responses. 👇
This is what happens when you don't understand science or medicine. 🤦🏻 Yes, if you take a medication for only 3 years and stop taking it, you will not have very much benefit. Especially, for a disease that is chronic and based on cumulative exposure to high LDL-C. If you take the
Statins for primary prevention? No thanks. In trials of 3.5-6 years duration, statins only postponed death by a median of 3 days. And 25-50% stop within 6-12 months, mainly because of adverse effects. And statins cause diabetes
Absolute risk vs relative risk. Carried out on a long enough time horizon, the absolute risk dwarfs the relative risk and the area under the curve continues to expand. From my new cholesterol book.
If a 45 year old quits smoking by age 50, their chance of
Want to know your chance of having soft plaque? Check apoB.
Want to know if you'll have a heart attack? Check apoB.
Want to know if you'll have a stroke? Check apoB.
Want to know if you'll die young? Check apoB.
Want to know if you'll have aortic valve disease? Check apoB.
All cardiologists should be prescribing GLP1RAs just like we now prescribe Farxiga, Jardiance, Invokana. It won't be long before GLP1RAs have heart failure indication! Mark my words! 💪🏻🫀🩺
Ironic that a heart surgeon is promoting a diet that kills you faster. Have you not read a study since 1920?
Red meat intake increases the risk of heart disease and other risk factors of heart disease (stroke, hypertension, heart attacks, plaque, inflammation):
It's never all or nothing.
Every time you choose meat over processed food, you are increasing your healthspan.
Even if all you can afford is the bulk package on sale at the discount store.
Isocaloric replacement of just 3% saturated fat in butter, milk, cheese reduced LDL cholesterol and improved blood flow to arteries. The SFA was replaced isocalorically for MUFA.
PESA trial. Young healthy individuals with no CAC had ASCVD in multiple arterial beds at "normal" LDL-C of 110. At LDL-C of 150, it was nearly 70%. Read the part about calcium closely...
"among PESA participants with CACS=0, nearly 60% had plaques at other vascular sites"
What did nature intend for lions to eat? Other animals. Shocking that lions figured it out without RCTs. I’m worried about their LDL level.
What did nature intend for zebras to eat? Grass. Also shocking that zebras figured it out without RCTs. I’m worried about the lack of
@drjasonfung
Maybe you can post the correct chart from the study. As non-HDL increased, so did CV and all cause mortality. The figure you posted is strength of the association across different ages. Notice in your chart BMI also flat. Should we conclude that obesity doesn't affect heart
Tell me you aren't a scientist without telling me. Saturated fat absolutely increase CV event rates, MACE, CV mortality, and all-cause mortality. Citing your own publication is not evidence. Actual Evidence: 👇🏻👇🏻👇🏻
Finland North Karelia project: Reducing saturated fat, reduced CV
But wait, didn't sugar cause every disease known to humanity? 🤣🤣🤣 When will people understand that sugar, in and of itself, isn't a problem. If you are in a calorie surplus, there are ways in which excess calories from sugar, or any other macronutrient, may worsen diseases.
I believe BBBE is bacon, beef, butter and eggs.
What an incredibly idiotic and dangerous diet. And another one self-identifying as LMHR on order to hand wave away those LDL and TC scores. And the trigs! 🤦🏼♀️
#Carnivore
#BBBE
As a cardiologist, obesity physician, and certified personal trainer, I agree with Layne! Too often doctors opine on topics they really aren't experts in. While it may feel good to say "it's not calories", it's incorrect.
Having practiced obesity medicine for 12+ years, I can
This is the MOST HEATED I’VE EVER BEEN ON A VIDEO 😤
“Calories in calories out doesn’t work for everyone!”
YES IT F***ING DOES! STOP DISEMPOWERING PEOPLE!
This segment on
@oprah
made me absolutely heated. First off let’s get rid of this idea that calories in calories out
Read the book The Death of Expertise by Tom Nichols (
@RadioFreeTom
). You can't just say you "agree to disagree" when your aren't an expert in that field.
@BioLayne
is an expert in the field. Your opinion is meaningless. His opinion is far more researched and valid. That's like
@BioLayne
Agree to disagree. If someone is getting ~50 g a day from apples, blueberries, etc., there is no concern with their intake. If they are getting ~50 g a day from soda, other sugar-sweetened beverages, and other processed foods, that’s the issue
How about over 2 million people and over 20 million person years of follow up? Most comprehensive data set. Stop citing anything else!
#ldlkills
#ldl
#cholesterol
#apob
Dr Thomas Dayspring designed this Lipoprotein model. Highly recommend all physicians familiarize themselves with lipids!
#lipids
#lipidology
#cholesterol
@ifixhearts
As a pathologist doing around 10,000 autopsies, I can confirm that cholesterol does not cause cardiovascular disease.
@MohammedAlo
has had poor training and shitty mentors. I wonder if he has witnessed an autopsy of any one of his patients.
Why Are We Still Ice Bathing? It just doesn’t make scientific sense apart from placebo (and the mind is a very powerful thing, especially for elite athletes).
This is why patients don't get treated earlier. Because of Medfluencer accounts like this telling people that high cholesterol is ok. This is shameful. You are the problem!
I agree and disagree with this doctor's take.
I disagree with this thinking:
-Says high LDL is a problem
-Doesn't mention the patient's diet
-Recommends pharma interventions
I agree with the part where he says we should be having conversations earlier.
But high cholesterol
Which is why you are a surgeon. The rest of us read textbooks and treat patients for life beyond the 5 minutes you've known them before surgery and never see them again. Please just stop. You have no idea what you are saying.
I've done over 3,000 heart surgeries and run a concierge medical practice, and you tell me to read a basic nutrition textbook.
This is credentialism as its worst.
I say diabetics should not eat sugar out of vast direct experience on this topic.
I would never trust a textbook
You forgot the part about every study that has ever been done on lowering cholesterol has shown that it reduces heart disease, MACE, CV mortality, and all-cause mortality.
LDL-C is 645 mg/dL and total is 739 mg/dL and we are wondering if this is ok or normal? My goodness! I don't want or need any more business. Please stay out of my cath lab! 😭😞
Agreed. Ketosis is an adaptive mechanism to help us survive extreme circumstances, but not needed in the modern world. Can you do it if you find it helpful to lose weight? Sure. But probably shouldn't be long term.
Carnivore MD no longer does Keto-Carnivore because he thinks it’s unhealthy—stemming from self-reported adverse effects of chronic nutritional ketosis.
You can’t make this stuff up. What a world.
Killing yourself faster isn't smart. Leave the lipidology to the experts. CAC is an end stage finding. You don't want to wait until you have lung cancer to stop smoking. You have tons of soft plaque. And it's increasing at an extremely fast rate. It'll eventually be too late.
I had my first CAC scan today at age 41. Since 2016, I've been following a low carb/keto/carnivore diet. My metabolic panel has been perfect except for cholesterol.
Despite my LDL levels ranging from 220s-320s for 7 years 😬, my CAC score is ZERO! 😎 I’m not on statin, I don’t
Reducing LDL Reduced All cause Mortality:
Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials.
"Across all 26 trials, all-cause mortality was reduced by 10% per 1 mmol/L LDL reduction"
CAC increasing in early 40s, high LDL C, but ratios of cholesterol good.
It's all going well in carnivore world.
Over 600 hundred days carnivore but now had to go only beef, butter, bacon & egg.
What could go wrong on the true human diet?
@BradCohn
@BioLayne
You just don't understand science nor data. Please just stop. I've posted tons of videos on this topic and reverse causality. You aren't the first person to discover these studies and charts. I can design a study to show you almost anything you want pretty definitely. You need to
Statins reduce all cause mortality. Let's stop looking at one single data set. Here's all the studies and links.
#statin
#mortality
#allcausemortality
Meta Analysis of 26 studies showing that All Cause Mortality Lower by Lowering LDL
"Across all 26 trials, all-cause mortality
What should my cholesterol and lipid numbers be? I get this question every day. Here's a graph I decided to make for you guys! 💪🏻🫀❤️
You want to be below the 20th percentile for most people. If you are higher risk, you want to be below the 5th percentile!
Please share and
It can worsen and accelerate ASCVD. But it's not the cause. LDL-C or ApoB is the cause. Diabetics make up only 25% of acute coronary syndrome patients. So 75% of heart attack patients don't have diabetes. If you are born with a PCSK9 LOF mutation, you have are living your entire
Actually, diabetes is absolutely genetic. We still don't have a way to change genetics. Maybe soon. Losing weight can definitely help. But misinformation isn't helping. At least 17 alleles have been identified.
If you have type 2 diabetes, you’re eating the wrong food. That simple. It’s NOT a drug deficiency or genetic problem.
Approach it like an intolerance to sugar and starches. Fix your diet and you will come off medications.
Type 2 diabetes is preventable and often reversible.
Stanford and Cleveland clinic really need to dump Hyman and Huberman. Such quackery. Who on earth thinks taking 132 supplements is safe. You are putting unregulated, contaminated Toxins into your body.
Today was my career record for de-prescribing supplements: lovely new patient with CAD taking a total of 132 supplements per day(yes you read that right!) thanks to all of the “longevity” experts who love a grift. We replaced them all with $4 rosuvastatin. Wellness is unwell.