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Ethan Perlstein bio/acc Profile
Ethan Perlstein bio/acc

@eperlste

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ceo @PerlaraPBC (@ycombinator W16), ceo @epalrestat, ceo @endrarediseases, solo vc @AngelList, evo pharmacologist, mTOR worshipper, cofounder of K&L

Bicoastal
Joined January 2011
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@eperlste
Ethan Perlstein bio/acc
4 years
PMM2-CDG pioneer Maggie has been on epalrestat for almost two years as part of an ongoing single-patient IND study. Her first dose was January 2020. See the results with your own eyes šŸ‘‡
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@eperlste
Ethan Perlstein bio/acc
17 hours
Why stop at a kidney?. Blood, sperm, and ovaries are fungible too!.
@LNuzhna
Lada
18 hours
Biotechs would say stuff like "we can't raise money" but founder still has 2 kidneys. Curious.
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@eperlste
Ethan Perlstein bio/acc
20 hours
If the frontier models today can save 10 hours for every one of the 50M+ PhD scientist on Earth, that equates to a collective productivity unlock of 1000 millennia!. We have no idea what’s coming, but it’s the biggest thing since sliced bread.
@DeryaTR_
Derya Unutmaz, MD
1 day
This graphic doesn’t even represent the advanced AI models. What OpenAI or Google DeepResearch models can complete in 15-20 minutes would take me dozens of hours. I’m also testing a model that’s even much further ahead…what’s coming is a far bigger hurricane! I’ll keep warningā˜ŗļø.
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@eperlste
Ethan Perlstein bio/acc
20 hours
This FDA is the most community engaged I’ve ever seen — take them up on their offer!.
@US_FDA
U.S. FDA
1 day
Got a question for the FDA Commissioner?. In our next FDA Direct conversation, we'll be fielding questions from the audience. Click the link below to submit yours!.
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@eperlste
Ethan Perlstein bio/acc
2 days
RT @ElliotHershberg: This is one of the core questions I tried to answer in my recent essay on virtual cells. If we are still far from mod….
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@eperlste
Ethan Perlstein bio/acc
3 days
If anyone wants a training set on drug responses in yeast, you know where to find me.
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@eperlste
Ethan Perlstein bio/acc
3 days
Love all the talk about virtual (human) cells. But I’ve yet to see any model accurately predict drug response in a simple yeast cell let alone in a complex differentiated human cell. Show me you can accurately predict perturbations in a yeast cell, then I’ll take notice. I.
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@eperlste
Ethan Perlstein bio/acc
3 days
Weekends are for vibe CEOing.
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@eperlste
Ethan Perlstein bio/acc
3 days
Founders who are still sleeping on AI will be outcompeted by founders who embrace it as the curve goes exponential. AI selection > natural selection.
@DeryaTR_
Derya Unutmaz, MD
3 days
Essentially, they succeeded in ~30% of tasks now. Conservatively, this will increase by an average of 10% every 3–4 months. So within a year, they will succeed in 70% of real-world tasks, and in 18 months, they will perform virtually all office tasks with 95–99% efficiency.
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@eperlste
Ethan Perlstein bio/acc
5 days
Bet on one of the hyperscalers or play the field with a model of models?. What’s a scientist founder to do on the brink of AGI?.
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@eperlste
Ethan Perlstein bio/acc
7 days
Snoozefest….who wants to watch a bunch of TradBio GenXers in suits take back-to-back BD meetings?. Until biotech CEOs are young, hot and charismatic, good luck winning the vibe war.
@bradloncar
Brad Loncar
7 days
@anthonystaj Bingo. There should be a Kendall Square show that makes working in bio look like Silicon Valley.
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@eperlste
Ethan Perlstein bio/acc
11 days
Apparently the dire wolf is alive and well in Portland
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@dwarkeshpodcast
Dwarkesh Podcast
11 days
Colossal didn't make an exact copy of a dire wolf — they made "dire wolf 2.0", an attempt to edit the minimum number of genes to capture the phenotypes that made dire wolves distinct from gray wolves. George Church, the co-founder, explains their approach: "In a way, these are
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@eperlste
Ethan Perlstein bio/acc
11 days
RT @PRVWatch: Four Bills were introduced in Feb/March to reauthorize the Medical Countermeasure PRV and Rare Pediatric PRV Programs. No hea….
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@eperlste
Ethan Perlstein bio/acc
13 days
RT @UrsaBio: Yes.
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@eperlste
Ethan Perlstein bio/acc
13 days
If you’re a scientist or a founder, AGI is almost here. Ride the wave or get crushed by it. Don’t take my word for it, listen to @satyanadella’s counsel
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@eperlste
Ethan Perlstein bio/acc
14 days
RT @signulll: one under discussed part of the mamdani campaign was the usage of the video filters. every video used the same soft, humanizi….
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@eperlste
Ethan Perlstein bio/acc
14 days
Many of those ā€œsingle knobsā€ are rare disease genes.
@dwarkesh_sp
Dwarkesh Patel
14 days
One of the biggest updates from my interview of @geochurch was how even massively polygenic traits (like height, intelligence, etc) might be surprisingly malleable through germline gene editing (which is currently only tractable for a couple dozen sites). For many traits, there
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@eperlste
Ethan Perlstein bio/acc
15 days
The best advice I can give other founders:. If life gives you lemons, squeeze the shit out of them — then add sugar.
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@eperlste
Ethan Perlstein bio/acc
15 days
Hence the best founders will be the best prompters. AI unlimits founders.
@balajis
Balaji
15 days
Tech is limited by founders. AI is limited by prompters.
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@eperlste
Ethan Perlstein bio/acc
15 days
Assemblyman Dickpic has a nice ring to it
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@eperlste
Ethan Perlstein bio/acc
15 days
Will it be Mr Cardamom or Mr Oregano?
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