Ethan Perlstein bio/acc
@eperlste
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ceo @PerlaraPBC (@ycombinator W16), ceo @epalrestat, ceo @endrarediseases, solo vc @AngelList, evo pharmacologist, mTOR worshipper, cofounder of K&L
Bicoastal
Joined January 2011
PMM2-CDG pioneer Maggie has been on epalrestat for almost two years as part of an ongoing single-patient IND study. Her first dose was January 2020. See the results with your own eyes š
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RT @jchervinsky: The GENIUS Act passes the House by a huge margin, 307 - 122. The President will sign it into law tomorrow. We have stableā¦.
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The value prop of DeSci for Pharma is making the US competitive with China on clinical trial speed and cost. Prove to TradBio that onchain decentralized trials run vastly cheaper and faster, then theyāll be all over crypto. .
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I would hope that the scientists attending a psychedelics conference are on the substances they study in the lab.
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Pitting o3 vs Grok 4 against each other with identical prompts relating to biology specifically. So far not discerning much of a difference. Both are giving similar answers. Feels kinda like talking to a pair of identical twins who were separated at birth.
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How are the 10,000+ rare diseases affecting 1 in 10 Americans NOT a national priority?.
Marty Makary FDA Commissioner discusses the Commissioner's National Priority Voucher Program on CNBC: What qualifies as a national priority?.š¹Large unmet public health need. Would like to see:.- cure for T1 diabetes .- more cancer therapies for stage 4 metastatic disease .-.
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RT @eperlste: The biggest regret I have from my all-too-brief stint as CSO of @ReeveFoundation that was cut short by COVID was not being abā¦.
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The biggest regret I have from my all-too-brief stint as CSO of @ReeveFoundation that was cut short by COVID was not being able to close a partnership with @neuralink. @maxhodak_,whom I knew from YC, was there at the time and we had just one promising intro meeting in late.
šØNEURALINK IMPLANTS 7TH PATIENT, MEET JAKE SCHNEIDER. Jake becomes seventh brain chip recipient targeting neurodegenerative diseases. Vows to "redefine what is possible" as Neuralink expands beyond paralysis patients. Source: @PairedWith_P7 @neuralink
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The biggest regret I have from my all-too-brief stint as CSO of @ReeveFoundation that was cut short by COVID was not being able to close a partnership with @neuralink. @maxhodak_,whom I knew from YC, was there at the time and we had just one promising intro meeting in late.
šØNEURALINK IMPLANTS 7TH PATIENT, MEET JAKE SCHNEIDER. Jake becomes seventh brain chip recipient targeting neurodegenerative diseases. Vows to "redefine what is possible" as Neuralink expands beyond paralysis patients. Source: @PairedWith_P7 @neuralink
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TradBio is wringing its hands over China eating its lunch, but completely asleep at the wheel on AI which will drive incalculable innovation from below.
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RT @endrarediseases: Curetopia Lab Meeting livestream will be on Monday July 14 @ 9AM PACIFIC . Weāve been heads down cooking and we have tā¦.
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Why stop at a kidney?. Blood, sperm, and ovaries are fungible too!.
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If the frontier models today can save 10 hours for every one of the 50M+ PhD scientist on Earth, that equates to a collective productivity unlock of 1000 millennia!. We have no idea whatās coming, but itās the biggest thing since sliced bread.
This graphic doesnāt even represent the advanced AI models. What OpenAI or Google DeepResearch models can complete in 15-20 minutes would take me dozens of hours. Iām also testing a model thatās even much further aheadā¦whatās coming is a far bigger hurricane! Iāll keep warningāŗļø.
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This FDA is the most community engaged Iāve ever seen ā take them up on their offer!.
Got a question for the FDA Commissioner?. In our next FDA Direct conversation, we'll be fielding questions from the audience. Click the link below to submit yours!.
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RT @ElliotHershberg: This is one of the core questions I tried to answer in my recent essay on virtual cells. If we are still far from modā¦.
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If anyone wants a training set on drug responses in yeast, you know where to find me.
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Love all the talk about virtual (human) cells. But Iāve yet to see any model accurately predict drug response in a simple yeast cell let alone in a complex differentiated human cell. Show me you can accurately predict perturbations in a yeast cell, then Iāll take notice. I.
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