Basavraj khanppnavar
@BasurajSK
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Scientist at Paul Scherrer Institut. Interested in #Cellular signalling and homeostasis #Host-Pathogen interacations #Enzyme Biotechnology
Switzerland
Joined April 2012
Feels great to be part of this #TrendsTalk and also to contribute a excellent review highlighting new structural insights membrane #adenylyl cyclases (initiators of #cAMP signaling). https://t.co/hiMT4qbvWD
cell.com
Membrane adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. As effector proteins of G protein-coupled receptors and other signaling pathways, ACs receive...
In a TrendsTalk from last week's @TrendsBiochem special issue on #StructuralBiology, four structural biologists discuss pertinent challenges and opportunities in the field. Read the TrendsTalk: https://t.co/wvWMaQVkzJ
@BasurajSK, @rachel_a_north, @PPMC_UAB, and Yanhui Xu
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Structural snapshots capture nucleotide release at the μ-opioid receptor | Nature
nature.com
Nature - Structures of GDP-bound MOR–Gi conformational states combined with pharmacological assays show an inverse correlation between ligand efficacy and GDP affinity, where agonists...
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Our 5th paper on dengue virus protease NS2B/NS3 just out in PNAS Nexus (OUP)! It sheds light on the enzyme’s complex mechanism — a step closer to better antivirals. 🔗
academic.oup.com
Abstract. Several enzymes receive functional signals from allosteric site to the active site through conformational dynamics while domain dynamics can also
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Delighted to share our latest study on atypical activation and dimerization of an intrinsically-biased chemokine receptor, CXCR7! Atypical activation and molecular glue-like dimerization mechanism of an intrinsically-biased chemokine receptor
biorxiv.org
CXCR7, also known as atypical chemokine receptor 3 (ACKR3), is a naturally-biased, β-arrestin-coupled seven transmembrane receptor (7TMR) that lacks productive coupling with heterotrimeric G-protei...
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Learn how our hunt for the native structure of top #antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms 👉 https://t.co/SX5vBW1ZzT 🦠🔬❄️ A team effort by @mehsehret @cmholab & Anurag Shukla @AkhilVaidya1 #cryoEM
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Role of the Active Site Heme and Tyrosine in Styrene Oxide Isomerase’s Natural Isomerase and Unnatural Peroxidase and Peroxygenase Activity | ACS Catalysis
pubs.acs.org
Heme enzymes can perform a wide range of reactions in biological systems, often controlled by the heme surrounding amino acids or in conjunction with redox partners. Recently, we resolved the cryo-EM...
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In the latest issue! Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling
cell.com
Vasodilatory signals are rapidly communicated across long distances by endothelial-endothelial gap junctions, enabling coordinated dilation of the arterial network during neurovascular coupling.
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Once rare, Parkinson's disease is now the fastest growing neurodegenerative disease, with a new case diagnosed every 6 minutes in the US. Why? I argue that it's lax regulation of toxic chemicals, from pesticides to those used in dry cleaning. Read:
nytimes.com
There is a growing mountain of imperfect but troubling evidence that pesticides and other chemicals may be behind the exploding rates of the disease.
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Our article on the allosteric modulation of SV2A is now online at PNAS:
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Structure-guided engineering of snake toxins for selective modulation of adrenergic and muscarinic receptors https://t.co/WnBhHEKRVr
nature.com
Nature Communications - Adrenergic and muscarinic receptors are key GPCRs involved in vital functions. Here, the authors engineer toxin variants that selectively target α2A and M4AChR,...
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The elusive mechanism by which ATP is translocated into the ER in exchange for ADP has been revealed by a fantastic paper by my colleagues in the David Drew lab! Congratulations to all who contributed in this amazing well rounded study! https://t.co/pJCSirmo40
nature.com
Nature - SLC35B1, initially thought to be a nucleotide sugar transporter, is an essential ATP/ADP exchanger that imports ATP into the endoplasmic reticulum through a unique stepwise translocation...
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I am delighted to share our findings on the binding mode of tetanus neurotoxin and the anti-epileptic drug Levetiracetam to SV2A, an essential synaptic vesicle membrane protein of unknown function, now online in @NatComms https://t.co/PaTTAxT4Jn
nature.com
Nature Communications - SV2A, an essential membrane protein in neurotransmission, is known as the receptor of clostridial neurotoxins and target of anti-epileptic drugs. Here the authors show...
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Happy to share our recent work in @NAR_Open
https://t.co/7apsNu9n52. We unravel the mechanism of deamination of Mycobacterium enzyme that selects for mutagenic bases, protecting Mtb from triazines. Kudos to @Chakrabarti_Lab and @TheRALab1 for their collaborative efforts.
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Check out our new study revealing how ATP-independent activator Bpa binds asymmetrically to the Mtb #proteasome — and pinpointing key Bpa residues involved in substrate interaction. 👏 Tatjana v. Rosen @Rafal_Zdanowicz @yasserelhadeg 🔗 https://t.co/Pi5A5YhlX7
nature.com
Nature Communications - Mycobacterium tuberculosis has a proteasome similar to eukaryotes. This study reveals how the activator Bpa recruits its substrate HspR, providing structural and mechanistic...
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Our investigation of lipid dependence of Cx32 gap junction channel conformations is now online on @biorxivpreprint. Great work by @PLavriha, @FluriCarina and Jorge Hernández González! https://t.co/qY1wddLPcs
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Many thanks @biopatrika for this opportunity and sharing our findings on #Botox.
#Authorinterview: Basavraj Khanppnavar a structural biologist and biochemist talks about his work on "Molecular Snapshots Unravel Botox’s Secrets of Nerve Cell Entry". #botox #cryoEM #neuron @BasurajSK @KorkhovLab
@ETH_en
https://t.co/nmV8iEc0kx via @biopatrika
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Happy to share our latest publication on @NatureSMB Natural Structure & Molecular Biology, we show tau filaments show Alzheimer fold in mutants V337M and R406W. https://t.co/yffK99Li7A
https://t.co/EFTrDO14YA thanks @SjorsScheres and @MichelGoed support 🥳🥳🥳
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Male blue-lined octopuses inject females with venom during mating to avoid being eaten by their partners https://t.co/RbUH3HcMlV
nature.com
Nature - The paralysing toxin deployed by the male blue-lined octopus might help to protect him from being eaten.
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Molecular-dynamics simulations of seven selected ligands of the ACDC domain of Plasmidium ApiAP2 provide a new molecular basis for the future design of ACDC inhibitors https://t.co/g0GS5BwLfz
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Very excited to announce that I have moved across the pond to start my new position as Assistant Director for Chemoproteomics @ the Nucleus @Stanford_ChEMH. This position allows me to do what I love: fun science, collaborations & teaching everyone about the wonders of #masspec 🥳
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Fantastic work by our collaborators and colleagues who decipher the role of apicoplast in Toxoplasma gondii.
🚨New paper out! 🚨 The apicoplast is an essential plastid retaining many crucial metabolic pathways 🦠🏭 However, bypassing all of them makes the apicoplast dispensable! https://t.co/ELkGjzaE2Q
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