This parasite can be continuously cultured, offering a valuable tool for apicoplast research and drug discovery! 💊🔬.Congrats to all the authors involved for this amazing piece of work! 👏🎉.

🚨New paper out! 🚨 .The apicoplast is an essential plastid retaining many crucial metabolic pathways 🦠🏭 However, bypassing all of them makes the apicoplast dispensable! .

RT @SanchezSyrian: Excited to see our paper published in MBOC! 🎉 Our research explores a glyoxalase-like protein in the apicoplast, crucial….

RT @SheinerLab: Our structure-function analysis of the #Toxoplasma #mitoribosome reveals a novel role for poly A tails and repurposed prote….

RT @Hashemyaser4: It's a great pleasure to share our latest collaborative work detailing the composition and structure of the highly rRNA-f….

Last but not least, big congrats to @Hashemyaser4 @OscarVadas and all the others authors involved! 👏🎉🐈‍⬛.

These findings highlight a novel adaptation shared between the Alveolata, by which transcription factors evolved into RNA-binding proteins. Targeting this unique mitoribosome assembly machinery could open new possibilities to treat diseases such as malaria and toxoplasmosis. 🦠💊.

Surprisingly, these AP2s (mtAP2s) don’t bind to DNA but ribosomal RNA! Cryo-EM showed T. gondii's mitoribosome are highly complex, with over 120 proteins and more than 40 fragmented RNA pieces. ❄️🔬 The mtAP2s stitch all these pieces together, creating a functional mitoribosome.

Alveolates have the smallest mitochondrial genome! It only encodes for 2-3 proteins and highly fragmented ribosomal RNAs 🧬 Besides, 4 transcription factors (ApiAP2s) were found in T. gondii as essential components of its mitoribosomes ⚡️🦠.

Mitochondria are the powerhouse of the cell, producing essential energy for life 🏭⚙️. To synthesize the proteins for this process, mitochondria have mitoribosomes. But, how do the mitoribosomes from Alveolates assemble? 🧵 .

Christmas is coming ☃️, and in Switzerland this means. fondue! 🫕 Enjoying tons of cheese with #Brochetlab and @AmandineGuerin5 lab 🧀❄️🔬

RT @GCIR_Unige: How does #Toxoplasma gondii move? @unige_en scientists reveal apical polar ring & conoid as key players controlling actin f….

Thanks to the wonderful collaboration with @yiweichang 🤝 and congratulations to @Bingjian_Ren, @Romzouz1 and all the authors involved! 🔬❄️🎉.

In this article, a repertoire of apical polar ring proteins was studied and assigned to the different APR layers. Among them, APR2 contributed to parasite's motility and invasion and its depletion caused destabilisation of the APR middle layer and F-actin leakage to the cytosol.

🚨 New publication out: Architecture of the Toxoplasma gondii apical polar ring and its role in gliding motility and invasion 🧫🐈‍⬛. Read more .

Congrats to @SanchezSyrian and all the authors involved in the paper describing a novel protein involved in apicoplast homeostasis and parasite growth! 👏🦠🐈‍⬛.

RT @par_papers: RNG2 tethers the conoid to the apical polar ring in Toxoplasma gondii: a key mechanism in parasite motility and invasion ht….

RT @JournalSpectrum: New study from @KevinBrownLab and @SoldatiLabToxo explores whether calcium mobilization pathways are conserved between….

Congrats to @RouaaBc and all the authors for putting another piece into the rhoptry disharge puzzle! 👏🏼🧩.Yet another successful collaboration with @yiweichang ! 🤝🏼.

Congrats to @Romzouz1 and the @AmandineGuerin5 lab for this beautiful piece of work! 👏New insights on the nucleation of tubulin structures, both in Toxoplasma and Cryptosporidium, with wonderful microscopy 🔬🦠.