Pia Lavriha
@PLavriha
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Researcher in the @KorkhovLab at ETH Zurich and Paul Scherrer Institute. Avid reader and an overly passionate F1 fan.
Joined November 2021
Come work with us at the Nucleus @Stanford_ChEMH! Happy to help you with proteome analyses, identifying your drug targets, understanding drug mechanisms, and much more 🔎🕵🏻
The Chemoproteomics Group at the Nucleus, led by @dina_sch, uses mass spec-based techniques to study proteins & their molecular interactions. The group supports @Stanford researchers throughout a project, from design consultation to data analysis. https://t.co/a6dJTZaMxl
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Our investigation of lipid dependence of Cx32 gap junction channel conformations is now online on @biorxivpreprint. Great work by @PLavriha, @FluriCarina and Jorge Hernández González! https://t.co/qY1wddLPcs
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Our joint study led by @BasurajSK and Oneda Leka, on the interactions between botulinum neurotoxin BoNT/A1 and its receptor SV2B, is now out in @NatureComms. This was a great collaboration with the group of Richard Kammerer (@psich_en)! https://t.co/VQzCf0BZ0F
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Our study led by @xinyue_ding, joint with Simone Aureli, @gervasiolab, and @Picotti_Lab, describing the structural basis of Cx36 gap junction channel inhibition by small molecule drugs, is out in @CellDiscovery 👇 https://t.co/wAhqmPHQqH
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guys check this out!
Our paper on integrative structural biology analysis of adenylyl cyclase AC8 and its interactions with regulators is now out in @emboreports 👇 https://t.co/lVgOo2nxxw
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A beautiful summary of our recent findings from the @KorkhovLab on the structure and function of membrane bound adenylyl cylases is out. A very cool class of proteins often over shadowed by GPCRs (also cool). Great colleague=great science. Good job team! https://t.co/N6QyMqQjpc
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We (@KorkhovLab) wrote a review on membrane adenylyl cyclases, what we know about their structure & structural aspects of their regulation. They are fascinating proteins, with interesting differences between the different isoforms. Read more here ⬇️ https://t.co/vVkGRERwrd
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Last Thursday we went to test how well our lab skills translate to other activities. ✨ We tested our problem solving skills in boda borg and made cocktails, which is almost like preparing buffers (but a bit tastier 🤫). Here are some impressions from our group activity!
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Another wonderful study from our colleagues @PLavriha & @yufei_han who further characterised the interactions of 2-APB and #antimalarial drugs with two other isoforms #connexin Cx32 & Cx43 #channels using cryo-EM and cellular assays.
We are excited to share our manuscript on connexin gap junction channel interactions with drugs, led by @PLavriha and @yufei_han_, together with @xinyue_ding, @qichao8886 and @anandvaithia. Now on bioRxiv 👇 https://t.co/hkvpP7ey2a
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I am very happy our study on Connexin interaction with drugs and their influence on gap junction channel permeability is out on biorxiv. 🥳 many thanks to @yufei_han_ , @KorkhovLab and everyone who helped with the project ✨
We are excited to share our manuscript on connexin gap junction channel interactions with drugs, led by @PLavriha and @yufei_han_, together with @xinyue_ding, @qichao8886 and @anandvaithia. Now on bioRxiv 👇 https://t.co/hkvpP7ey2a
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Our study, led by Xinyue Ding in collaboration with @gervasiolab, exploring the molecular mechanisms of Cx36 gap junction channel inhibition by antimalarial drugs is now online👇 https://t.co/v25MjVEu56
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A bit of an update! On Thursday I successfully defended my PhD. 🥳 I am extremely grateful to all who helped me on the way and made my PhD journey in the @KorkhovLab an amazing experience. 🎉🎊
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https://t.co/manUvPfJgb My first paper as a postdoc in the lab David Drew is out Check-out the.first structure of a unique transporter which is regulated by a voltage sensing domain. Great team work!!
nature.com
Nature - Upon hyperpolarization, the S4 voltage-sensing segment of sea urchin SLC9C1 moves down, removing inhibition caused by an intracellular helix and enabling Na+/H+ exchange, leading to...
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"Please make no mistake. Climate change is the biggest threat to global security that modern humans have ever faced." Sir David Attenborough. No time to wait. #ActOnClimate
#climate #energy #wildfires
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The #CryoEM structure of the connexin-43 gap junction channel in a putative closed state helps researchers develop a mechanistic model for connexin activation. https://t.co/wGSvS7MgXC
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Our paper on the structural and functional studies on AC8 is on bioarxiv. Great effort by the team! It is great to see implementation of complimentary techniques such as LiP-MS that add to Cryo-EM in order to probe structural and functional questions https://t.co/htxm3v3SSa
biorxiv.org
Membrane adenylyl cyclase AC8 is regulated by G proteins and calmodulin (CaM), mediating the crosstalk between cAMP pathway and Ca2+ signalling. Despite the importance of AC8 in physiology, including...
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The paper by @KorkhovLab, joint with @Picotti_Lab and Mario Bortolozzi group (@UniPadova), out in @ScienceAdvances, describes the cryo-EM structures of Cx32 channels and reveals a molecular defect in hemichannels of CMT1X-associated Cx32 mutants. More: https://t.co/SCjFoNfs0S
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The link to the story can be found here 🔬🧫
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Wopwop! Our story on Cx32 is out in Science Advances 🎉🥳 Thanks to @qichao8886 , @dina_sch and @anandvaithia and members of Bortolozzi group for a great collaborative work!
We are happy to share that our latest publication on Connexin32 hemichannels and gap junction channels by @qichao8886, @PLavriha, and Erva Bayraktar is out in @ScienceAdvances! 🧫 Read more about how CMT1X-related mutations influence Cx32 HC structure 👇 1/4
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