Nature - An analysis in 3D multidonor Chimeroids—a scalable multidonor human brain organoid model—shows that human genetic background may be an important mediator of neurotoxin...

Nature - Spatial and single-cell transcriptomic characterization of microglia in the mouse somatosensory cortex show that the state of these cells is determined by signals from diverse surrounding...

Nature - A single-cell atlas of the developing mouse cortex provides a temporal and spatial assessment of the molecular logic that drives the establishment and organization of cortical cell types.

Nature Neuroscience - The mechanisms underlying neuron specification and maturation are unclear. Here the authors provide an integrated epigenomic and transcriptomic analysis of mouse and marmoset...

Realizing the full utility of brain organoids as experimental systems to study human cortical development requires understanding whether organoids replicate the cellular and molecular events of this...

The neocortex has an unparalleled diversity of cell types, which are generated during development through a series of temporally orchestrated events that are under tight evolutionary constraint and...

In the neocortex, oligodendrocytes produce distinct amounts of myelin in each cortical layer and along the axons of individual neuron types. Here we present a comprehensive single-cell molecular map...

Human genetic studies have provided a wealth of information on genetic risk factors associated with neuropsychiatric diseases. However, whether different brain cell types are differentially affected...

Scientists applied the “Perturb-Seq” method to study dozens of genes that are associated with autism spectrum disorder, identifying how specific cell types in the developing mouse brain are impacted...

Nature - Neurons in the brain regulate the number and state of microglia in their local environment.

Read chapter Summary: Over the last few decades, research, activity, and funding has been devoted to improving the recruitment, retention, and advancement...

De novo heterozygous loss-of-function mutations in PTEN are strongly associated with Autism spectrum disorders (ASD); however, it is unclear how heterozygous mutations in this gene affects different...

Nature - Cortical organoids made from a mix of stem cells from different donors.

Maternal immune activation can affect the development of embryos, but the underlying mechanisms have been unclear. In a new study, Bridget Ostrem and colleagues show that embryonic microglia detect...