Nathan Archer
@ArcherLab
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Asst. Prof. of Dermatology @HopkinsMedicine. We study immune responses during skin infections and inflammatory diseases to develop novel immunotherapies
Baltimore, Maryland
Joined April 2022
Lung inflammation in patients with #eczema may be caused by a tissue-specific immune response to S. aureus, a common skin microbe. The recent @CellReports study led by @ArcherLab and @HopkinsMedicine researchers links eczema, S. aureus, and asthma. https://t.co/Qx2NAGQ2PG.
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Want to learn more about #biofilms and how they evade #antimicrobial killing or host #immunity? Please join us for the 3rd Shirtliff Biofilm Symposium on June 13th in Philly! Sign up below. https://t.co/HpcWsVJOTA
markshirtliffbiofilmfoundation.org
Join us for a full day of biofilm talks and networking including sessions on:‘Overcoming antimicrobial resistance: From a One Health Perspective’. The event will support activities in the Shi…
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Shout to @Jen_M_Wu and Laine Feller for representing @ArcherLab at the Gram+ Pathogens meeting. Both gave excellent talks on host responses to S. aureus #skin #infections and #inflammation. #ProudPI @HopkinsMedicine #dermatology
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I am excited to share that we received a Serendipity Grant from the @LEOFondet to study the role of adipocytes in #skin #inflammation. This is important, as obesity is linked to increased susceptibility of developing atopic dermatitis and psoriasis. https://t.co/G8JbJs02HJ
leo-foundation.org
The LEO Foundation has awarded five Serendipty Grants, with a total of just below DKK 18 million, in its latest round of funding.
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🔔Extended Submission Deadline!🔔 Due to popular demand, the Research Topic: "From Bench to Clinic: Novel Vaccines and Therapeutics – “Success Stories” is extended! Edited by: Prof. Nathan K. Archer, and Dr. Aru Venkatasubramaniam NEW Deadline: 27th Sept 2024 👉Get involved:
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Excited to share this publication by my MD/PhD student @ZachVanRoy on the complex roles of TNF during S. aureus craniotomy infection. https://t.co/tZUjG9pT1r
@UNMC_mdphd @UNMC_PathMicro #ProudPI
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Very proud of this latest work from the lab! As we suspected, the immune imprint from a lifetimes exposure to S. aureus might be the reason vaccine have continually failed to drive protective immunity.
The @McLoughlin_Lab and team @tcdbi report IL-10 inhibition during vaccination against #Staphylococcus aureus improves #vaccine efficacy and indicates that nasal colonization influences systemic T-cell responses: https://t.co/5mxwQegzDP
#Immunology
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Thankful for our ongoing collaboration with Drs. Kevin Garvin and Curtis Hartman to examine immune responses in patients with prosthetic joint infection in @jclinicalinvest . Study led by @aru_prabhakar and Chris Horn #biofilm
https://t.co/dYOyKGKVzk
Excellent research by Tammy Kielian, @UNMC_PathMicro professor, and collaborators at @unmc and @NorthwesternU Researchers explore treatment for biofilm infections
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Our most recent work on naRNA, a novel #Neutrophil extracellular trap (NET) component propagating #inflammation via NLRP3 #inflammasome is now out at #EMBO Reports 👉
embopress.org
imageimageNeutrophil extracellular traps are key features of cellular innate immunity mediated by polymorphonuclear neutrophils. The NET-associated RNA (naRNA) composite danger-associated molecular...
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Want to learn more about how S. aureus proteases promote skin #inflammation? Check out this review by @sabostars @JennySaito12 from @HopkinsMedicine. #dermtwitter
https://t.co/c29YaLsowZ
liebertpub.com
Skin homeostasis relies on a delicate balance between host proteases and protease inhibitors along with those secreted from microbial communities, as disruption to this harmony contributes to the...
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Excited to share this preprint describing a bacterial single-cell RNA-seq platform to interrogate biofilm heterogeneity and transcriptional adaptations following immune cell exposure. Great work by @LKorshoj! #Biofilm @UNMC_PathMicro
https://t.co/NurAlAzOxM
biorxiv.org
Biofilm formation is an important mechanism of survival and persistence for many bacterial pathogens. These multicellular communities contain subpopulations of cells that display vast metabolic and...
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Host stress drives tolerance & persistence: The bane of anti-microbial therapeutics @SophieHelaine @theconlonlab @DavisLabJHU & Russell @cornellvet discuss pathways that promote antibiotic recalcitrance of M.tuberculosis, S.aureus, S.enterica & Yersiniae https://t.co/CgDrre5Gs6
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Congrats to Yu Wang @HopkinsMedicine and @IBT_inc on study to develop dry formulations of the #Saureus #vaccine IBT-V02, which were effective against strains from around the world and may have utility in countries where cold storage is scarce. 👇 https://t.co/yML2ShcUZ4
frontiersin.org
Staphylococcus aureus is the leading cause of skin and soft tissue infections (SSTIs) in the U.S. as well as more serious invasive diseases, including bacter...
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.@KellenCavagnero, Gallo et al. @UCSDHealth use single-cell transcriptomics to identify dermal immune acting #fibroblast (IAF) subsets that communicate with #neutrophils during type 17 #inflammation. https://t.co/ejFJcSvdxw
#InnateImmunity
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Hot off the press, a comprehensive discussion of how Staphylococcus aureus exploits human proteins to persist as biofilm-associated infections. https://t.co/5Kzmjoklnk
@Horswill_Lab
academic.oup.com
A comprehensive discussion on the role of common host extracellular matrix proteins and how they contribute to biofilm formation during infections caused b
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1/11 Ever wondered why men have more S. aureus infections than women? Check out how testosterone stimulates S. aureus through activation of quorum sensing in our @harristryonlab preprint. Led by M. Sindhura John PhD @UTSWDerm. A #microbiome #staph#mrsa🧵 https://t.co/Pvj7VtsL61
biorxiv.org
Staphylococcus aureus, the most frequent cause of skin infections, is more common in men than women and selectively colonizes the skin during inflammation. Yet, the specific cues that drive infection...
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Featured Article: Neonatal microbial-skin crosstalk shapes allergic inflammation. Early postnatal colonization w/skin #microbiota, esp. IAld-producing #Staphylococcus, induces ILC2 priming by TSLP that promotes allergic skin inflammation in adulthood https://t.co/qy2pIwO8dS
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NEW Review of the immune response to bacterial T cell superantigens https://t.co/c168pCv2HG by @Superantigens @StephenTuffs @karine_dufresne @aanchal_rishi1 and @nickw_10 summarizing the expanding family of SAgs and their roles in multiple human diseases
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Happy to share our recent work let by postdoc @verenalink published today in @NatureMedicine. 👩🔬🥳Ketogenic and vegan diet differentially impact human immune system, microbiome and metabolism. (1/7) 🧵👇 https://t.co/W5KXzU8c1X
nature.com
Nature Medicine - In a post hoc multiomics analysis of a trial comparing a plant-based, low-fat diet to an animal-based, ketogenic diet, the diets have differential effects on peripheral immune...
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#NeutrophilPower! @ImmunityCP is on 🔥 today! Dong &co show that an alternative population of neutrophils produces the #neuropeptide FF that signals via a GPCR & inhibits #interferon gamma signaling in bystander neutrophils, balancing #lung tissue damage!
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