Lioba Koerner, Xiaoming Li, Eveline Silnov, Lucie Laurien, and Manolis Pasparakis show that RIPK1 autophosphorylation at S161 is crucial for regulating #CellDeath and #inflammation. https://t.co/RcIl7QG4VG From our #InnateImmunity collection: https://t.co/YCI5MmGvFJ

Han et al show that RIPK1 S161 autophosphorylation promotes further autophosphorylation & can substitute for RIPK1 kinase activity in TNF-induced #necroptosis-mediated cecal damage & mouse death https://t.co/V9mXjvnxo4 From our #InnateImmunity collection: https://t.co/lV6s39WQZ7

The STING pathway drives non-inflammatory #neurodegeneration in NGLY1 deficiency, say Kun Yang, Nan Yan and colleagues (UT Southwestern Medical Center): https://t.co/FXGQGsruvp From our Pattern Recognition Receptors & Beyond #InnateImmunity collection: https://t.co/fWJ2ANie91

Saidoune, Gilliet, @AhmadYatim_ et al. show that excessive TLR7 responses to #SARSCoV2 by pDCs are linked to I-IFN–driven chilblain development. https://t.co/1p70gml3wn From our Pattern Recognition Receptors & Beyond #InnateImmunity collection: https://t.co/NL4XWku4mZ

Ru et al. show that the accumulation of RNA lariats in human DBR1-deficient cells impairs #StressGranule assembly–mediated PKR activation, and thereby cell-intrinsic antiviral immunity. https://t.co/hL7heGCs3u From our #InnateImmunity collection: https://t.co/6lYzKZCrNY

Alexander Yang, @DonnaFarber3 and colleagues @columbiamed show how lung tissue resident memory T cells optimize protection through IL-10 production which regulates #macrophage-mediated #inflammation in the lungs. https://t.co/uraCXTC8ED #InnateImmunity #MucosalImmunology

We are pleased to present a special collection highlighting recent findings in the #InnateImmunity field. It spotlights cutting-edge research on the mechanistic aspects of innate immune signaling upon #infection, in #autoimmunity, & in #neurodegeneration https://t.co/0GzRUUXEot

A viral E3 ubiquitin ligase produced by herpes simplex virus 1 inhibits the NLRP1 #inflammasome, say @JustKOS1, @VirulentMind et al. https://t.co/1gsCSuS4NA From our Pattern Recognition Receptors & Beyond #InnateImmunity collection: https://t.co/UpAZHoH6rr

ICYMI: a special collection spotlighting recent, cutting-edge research on the mechanistic aspects of innate immune signaling upon #infection, in #autoimmunity, and in #neurodegeneration. https://t.co/62kGhpsZrw #InnateImmunity

Congratulations to JEM Editorial Board Co-Chair Carl Nathan on receiving the 2025 David & Beatrix Hamburg Award from @theNAMedicine for his fundamental work in improving understanding of #InnateImmunity:

.@Yaelalippe, @msdiamondlab et al. show that fetal MAVS & type I IFN signaling pathways control #Zika virus infection in the placenta and maternal decidua. https://t.co/WVniMsQLZd From our Pattern Recognition Receptors & Beyond #InnateImmunity collection: https://t.co/XhNNFTBzLj

Wouters, @IsabelleMeyts et al. @KU_Leuven show that next to biallelic deleterious mutations in ADA2, monoallelic dominant negative missense variants in ADA2 can also underlie ADA2 deficiency. https://t.co/lKpfLM1sGu From our #InnateImmunity collection: https://t.co/uKU22gJV2V

Congratulations to @JExpMed Editorial Board Co-Chair Carl Nathan on receiving the 2025 David & Beatrix Hamburg Award from @theNAMedicine for his fundamental work in improving understanding of #InnateImmunity:

🧵 Innate Immunity—The Unsung Heroes of Our Immune Defense👇 1/10 👋 Did you know your body has a rapid-response “first line” immune army that works before antibodies? This is #InnateImmunity—crucial not just in fighting infection, but in cancer, clotting, & even autoimmunity.

Excited to share this article with @Chauhanlab_ILS & team @ccmb_csir on intricate cross-talk b/w #Autophagy & #InnateImmunity. As my lab is starting to focus on innate immune responses against Fungal Pathogens, this was a super useful proces😀 Link: https://t.co/Ofk10AChbq

Wenjie Zhu, Xiaoyan Xu, Rachel Caspi @rcaspi @NatEyeInstitute @NIH et al. show that Vγ6 γδ T cells sense commensals via TLR2 to fuel IL-17A-mediated barrier defense at the ocular surface. https://t.co/d3nJgCNf9w From our #InnateImmunity collection: https://t.co/zMAInsbCRM

Isoform-specific mouse KO shows ADAR1p150 required in development and adults for hematopoiesis and suppression of interferon signaling #rnaediting #innateimmunity https://t.co/Di3LTXCud5

Carrot juice boosts immune response, cuts inflammation, new study reveals 🥕🔬💪 https://t.co/cUd8gRWfhc #CarrotJuice #Inflammation #ImmuneBoost #Nutrients #HealthyLiving #DietScience #InnateImmunity #AntiInflammatory @Nutrients_MDPI

Join us at 2pm for talks on the regulation of innate inflammatory responses by cell volume and how mechanical stress boosts NLRP3 inflammasome activation at @‌Inflammazoom, our free webinar series on #innateimmunity Use the link to join: https://t.co/JnXDe64CWf