Alec Walker
@AlecJWalker
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Neuroimmunologist, PhD student @stevens1lab // lover of good food and nature
Boston, MA
Joined March 2022
I’m thrilled to share the results of a phenomenal collaboration with Lasse Dissing-Olesen in the @stevens1lab. If you’re hungry for microglial biology and looking for a new set of utensils with which to dig in, please read on. https://t.co/DcCb0rtEfN 1/n
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Very happy to have started my lab at Stanford @DevBioStanford earlier this month. We will be studying mammalian embryo development, plasticity and resilience. Check out our new website for more details: https://t.co/gvQXRszmgv
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Excited to share our story about S. aureus and itch! https://t.co/2fc2v3bvD8
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Check out our new paper on BMAL1 in synapses in @ScienceAdvances ! Led by our talented former post-doc @IlariaBarone9
https://t.co/yUtv4KWU0r
science.org
The circadian protein BMAL1 rhythmically localizes to synapses and is crucial for corresponding rhythms in synaptic plasticity.
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Congratulations @alexa_schnell and co!! 🔥🎉
Excited to share part of my PhD research in @KuchrooLab published today @NatImmunol We identify PGLYRP1 as a novel inhibitory molecule on T cells, that when targeted, elicits anti-tumor immunity while protecting against autoimmune neuroinflammation. https://t.co/1jz87UCrN8
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Happy to share this paper led by fabulous postdoc Dan Wilton in collaboration with @synaptokevin @XWilliamYang1 and team. Highlights and Tweetorial to follow ..
#microglia mediate the early and selective degeneration of corticostriatal synapses and the development of cognitive deficits in presymptomatic #Huntington’s disease via the #complement cascade https://t.co/yDBSnRWvug
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Lasse and I also could not have done this without our dedicated co-authors - our deepest thanks to Fanny, Helena, @aliciawalkersci, Lili, Dan, Indrani, @stevens1lab, and the Benowitz lab. @BostonChildrens
@harvardmed
@broadinstitute
@lundbeckfonden
@NatureComms 5/5
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We hope that FEAST sets the table for discovery of novel microglial biology and look forward to seeing what you all find! 4/n
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Importantly, we outline methodological solutions for issues such as false-positive engulfment and a framework that should allow application of FEAST to study macrophage engulfment of other target proteins, in other organs, and across species. 3/n
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With our publication of FEAST, we provide a smorgasbord of innovative flow cytometry-based approaches for high-throughput assessment of microglial engulfment in health and disease. 2/n
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