David Gate
@DGateLab
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Director, Abrams Research Center, Northwestern Neurology. The Gate lab studies the immune system in neurodegenerative diseases.
Chicago, IL
Joined September 2019
Key to research success: ambition in vision, but pragmatism in execution. You must be guided by a long-term, ambitious goal that addresses a fundamental problem, rather than chasing incremental gains on established benchmarks. Yet, your progress should be grounded by tractable
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We are proud to announce a collaboration with @ARC_Neuro at Northwestern University Feinberg School of Medicine to harness AI for rapid discovery and innovation in Alzheimer’s disease research. Using Lens, the Center and Tempus teams will work together to uncover genomic patterns
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I am excited to present our new study out in @NatureMedicine where we discover a novel synaptic protein biomarker to predict if and when someone will get Alzheimer’s disease dementia. Part 2/3 from my PhD work in the @wysscoray lab. 🧵1/12 Full study 🔗:
nature.com
Nature Medicine - The ratio between the levels of two synaptic proteins in cerebrospinal fluid predicts future cognitive resilience versus decline among presymptomatic individuals and individuals...
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The Gate lab is fortunate to have such a talented scientist like @TerryRSuk joining us soon. Check out his impressive work!
We’re happy to share that our labs first #ALS and #FTD study “A stress-dependent TDP-43 SUMOylation program preserves neuronal function” is now online @MolNeuro! https://t.co/fqv8ivFde4
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In brains of people immunized against Aβ, postmortem omics reveal microglial plaque clearing pathways. @NorthwesternU
https://t.co/aKkrYJUioJ
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It’s quite an experience to have some of your favorite labs like @TheColonnaLab and @Haass_Lab comment on your lab’s research. Great reporting by Alzforum!
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This Northwestern Breakthroughs podcast nicely encapsulates our study. The host does a great job leading the discussion for the lay audience to digest our work. I hope this allows people to better understand the results and impact of this study.
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This video describes the findings from our recent study conducted at @ARC_Neuro. In the video, lead author @LynnOlst and I discuss the findings and their implications for Alzheimer’s disease.
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Big day today!
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Excited to share our latest @NatureMedicine study from our new center @ARC_Neuro! 🧠✨ Using spatial transcriptomics & scRNA-seq, we uncover how Aβ-targeting immunotherapies shape microglial responses in AD patient brains. A thread with our key findings is below! 🧵(1/15)
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Spatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passive and actively immunized #Alzheimer’s disease patients @NUFeinbergMed
https://t.co/DirVOwGV5r
nature.com
Nature Medicine - Spatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passively and actively immunized patients with Alzheimer’s disease.
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More excellent work from the brilliant @LynnOlst. I’m a very proud PI today. More to come from @ARC_Neuro!
Excited to share our latest @NatureMedicine study from our new center @ARC_Neuro! 🧠✨ Using spatial transcriptomics & scRNA-seq, we uncover how Aβ-targeting immunotherapies shape microglial responses in AD patient brains. A thread with our key findings is below! 🧵(1/15)
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Excited to announce that we are recruiting at our new Neurogenomics Center at Northwestern! We are looking for passionate postdoc candidates to join our team.
nature.com
A postdoctoral research fellowship in the Abrams Research Center on Neurogenomics at Northwestern University in downtown Chicago.
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The team at Abrams Research Center on Neurogenomics, led by @DGateLab, is excited to explore their new lab! Using #ArtificialIntelligence, genetic research and global collaborations, they’re advancing Alzheimer’s disease research. #NMBetter
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Located in vibrant downtown Chicago, our center features state-of-the-art equipment and infrastructure to make foundational discoveries in neurodegenerative disease research. Even if you are not yet finished pursuing your PhD, we want to hear from you!
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Excited to announce that we are recruiting at our new Neurogenomics Center at Northwestern! We are looking for passionate postdoc candidates to join our team.
nature.com
A postdoctoral research fellowship in the Abrams Research Center on Neurogenomics at Northwestern University in downtown Chicago.
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I’m proud to have contributed (slightly) to this tour de force by @ElisaFlo04
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Our December issue, featuring a Focus on Single Cell Genomics, is now live! https://t.co/SdhbkB1aLQ
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