Alexander Dilthey Profile
Alexander Dilthey

@AlexDilthey

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Bioinformatics, genetics and population genomics. Professor @HHU_de. MHC/HLA, graphs, long reads, SARS-CoV-2, microbiome. Own opinions.

Düsseldorf, Germany
Joined September 2012
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@AlexDilthey
Alexander Dilthey
3 years
Out now in @naturemethods: Emu, a new method for 16S rRNA @nanopore-based profiling of microbial communities! Great transatlantic collaboration with @kristendcurry, @traingene, et al. Brief thread follows.
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@AlexDilthey
Alexander Dilthey
1 month
RT @MartinJLercher: 🚀 We’ve launched the Night Science Institute! Our mission: to champion a cultural shift in science toward embracing the….
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@grok
Grok
4 days
Join millions who have switched to Grok.
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@AlexDilthey
Alexander Dilthey
1 month
RT @ItaiYanai: 🚀Today we're launching the 'Night Science Institute', a non-profit to lead a cultural shift in science! You may say we're dr….
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@AlexDilthey
Alexander Dilthey
2 months
RT @SaraCSchulte: Excited to share our paper on somatic variant calling in HLA genes and genes related to antigen presentation across a coh….
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@AlexDilthey
Alexander Dilthey
3 months
RT @VincentGeloso: I have been listening to EconTalk since I was an undergraduate student. I listened to the first episode, with Milton Fri….
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@AlexDilthey
Alexander Dilthey
4 months
RT @AlexTISYoung: In March last year, at the age of 35, I was diagnosed with advanced stage III rectal cancer with a metastasis in my liver….
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@AlexDilthey
Alexander Dilthey
5 months
RT @KarelBrinda: A decade ago, we had thousands of bacterial genomes. Now, we have millions. How to scale computational methods?. Our paper….
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@AlexDilthey
Alexander Dilthey
5 months
RT @chirgjain: The 3rd annual Symposium on Big Data Algorithms for Biology (BDBio) is happening this May! Join us for insightful talks and….
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@AlexDilthey
Alexander Dilthey
6 months
RT @tom_luedde: We found that activating programmed necrosis through genetic or pharmacological interventions might be an effective anti-ca….
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nature.com
Nature Communications - The involvement of cell death pathways in the early stage of pancreatic ductal adenocarcinoma (PDAC) development, especially KRAS-dependent acinar-to-ductal metaplasia...
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@AlexDilthey
Alexander Dilthey
7 months
RT @srikosuri: It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendr….
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@AlexDilthey
Alexander Dilthey
7 months
RT @EconTalker: Vote for your favorite EconTalk episodes of 2024! (And please RT):
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@AlexDilthey
Alexander Dilthey
8 months
RT @SolidEvidence: I finally solved the mystery of why there are so many cryptic lineages in Northern Ohio. This is a mystery I’ve been wo….
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@AlexDilthey
Alexander Dilthey
9 months
RT @chirgjain: New method speeds up genome alignment of complete and near-complete genome assemblies in minimap2. Can also be useful for fa….
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@AlexDilthey
Alexander Dilthey
9 months
RT @gangfang_1: Preprint alert 🚨 Cautions in the use of @nanopore sequencing to map DNA modifications: officially reported “accuracy” ≠ re….
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@AlexDilthey
Alexander Dilthey
10 months
RT @calebwatney: This is the best paper written so far about the impact of AI on scientific discovery
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@AlexDilthey
Alexander Dilthey
10 months
RT @flokraft_: I am excited to share our latest research findings with you. We have identified a new group of neurodevelopmental disorders,….
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science.org
Malformations of the brain are common and vary in severity, from negligible to potentially fatal. Their causes have not been fully elucidated. Here, we report pathogenic variants in the core protei...
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@AlexDilthey
Alexander Dilthey
10 months
RT @ZaminIqbal: I'm going to be advertising a PhD studentship (open to international students) working on long read pangenome / assembly al….
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@AlexDilthey
Alexander Dilthey
11 months
RT @ZaminIqbal: Daria Frolova's paper in plasmid relatedness now out in MGen! She uses rearrangement distances & shared seq content to buil….
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microbiologyresearch.org
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@AlexDilthey
Alexander Dilthey
11 months
As always, thanks to all colleagues and coworkers who contributed to the manuscript!.
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@AlexDilthey
Alexander Dilthey
11 months
If you are working in the field of outbreak investigation and would try or collaborate on the further validation / development of NanoCore, please reach out!.
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@AlexDilthey
Alexander Dilthey
11 months
Potential future work: Integrate support for assembly-based isolate comparisons, leveraging the accuracy of R10 chemistry flow cells; and extend the supported distance metrics beyond the bacterial core genome.
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