Conor Loynd
@conor_loynd
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Chemistry grad student @AChemSynBio . Climbing on (falling off) rocks when not in lab.
Somerville
Joined July 2016
New preprint by Quan Pham, on a facile strategy to attach any recombinant proteins onto AAV! The unparalleled precision it offers helped us generate retargeted AAV-nanobody conjugates with remarkable efficiency and selectivity in vitro and in vivo
biorxiv.org
The efficacy of current gene therapy approaches using adeno associated virus (AAV) vectors is limited by the poor control over their tissue tropism. Untargeted AAV vectors require high doses to...
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They also demonstrated that, not surprisingly, eCLIC is compatible with both SPAAC and IEDDA. Combined with dual-ncAA mutagenesis to introduce 5HTP and an azide-ncAA, eCLIC+SPAAC can be cleanly and site-specifically double label a protein
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We got a story, and it’s electric! 🔌⚡️ https://t.co/K7w6MTOWzc Can electrocatalysis be used to precisely modify a protein? Yes! Happy to finally share this work led by @conor_loynd and @SinghaSoumya. A 🧵 #ProteinElectrochemistry #NSFfunded
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