Tim Proctor
@tpr720
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Brain networks for memory and thinking age much worse than those for vision and movement in primates
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New pharma partnerships.
BREAKING: Gero Signs Potential Multi-Billion-$ Deal to Fuel Our Mission to Stop Aging --. A few years ago, my son, aged five at the time, asked what happened to the dinosaurs. After learning their sad story, he told me he wanted to fly to the Moon and defend Earth from falling
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Organ clock proteomics.
The immune system and brain are uniquely associated with healthspan and longevity, the latest insights from organ clock proteomics @NatureMedicine @wysscoray .
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Melatonin and neurodegeneration.
Unveiling mysteries of aging: the potential of melatonin in preventing neurodegenerative diseases in older adults.
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DNA methylation and senescence.
DNA methylation protects cancer cells against senescence.
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Ceiling of current life-extension.
Are longevity drugs in mice reaching a ceiling?. An analysis of life-extending effects from drugs/compounds in DrugAge per year reveals more studies in recent years but not greater longevity benefits. 1/3
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Shortcomings of transfusions.
Disappointing results continue to accumulate in longevity research regarding efforts to remove or replace aged blood plasma in humans. The removal of old plasma (via plasmapheresis) was thought to eliminate pro-aging factors. In Borsky et al. (2025), healthy middle aged adults
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Restoring lost brain function.
NEW: No technology currently exists to repair damaged brain tissue and fully restore lost function. FRONT aims to enable millions with what is considered permanent brain damage to regain lost functions, including motor control, vision, and speech.
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Exercise’s healthspan dilemma.
Early-life exercise extends healthspan but not lifespan in mice.
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Psilocybin lifespan extension.
If the lifespan extending effects of psilocybin in cells and mice replicate, there’s something very meaningful happening biologically that deserves attention.
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This Week in Longevity X. - How does psilocybin affect aging?.- Does exercise increase lifespan?.- How can lost brain function be restored?. And much more!
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Creatine and senescence.
Creatine and cellular senescence: from molecular pathways to populational health.
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Brain aging from a single MRI.
How fast is your brain aging?.A new clock from a single MRI, validated in multiple datasets, linked with risk of dementia, cognition, chronic diseases and mortality .
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Germany’s longevity shift.
GERMANY CALLS FOR MEDICINE TO TREAT AGING, NOT JUST DISEASE.
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AI discoveries for fibrosis.
My dear friends, I have a great story to share. After a night of hard work, one of my agents working on real-time monitoring of publications related to targets of interest informed me of a high-profile publication on TNIK. And when I clicked on the link, I almost fell out of my
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Estrogen benefits post-menopause.
New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports.
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Centenarians biomarker.
NEW STUDY: Only 14 centenarians in this study but higher heart rate variability (SDNN) was associated with longer life. How do you know your SDNN? 🧵
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Theories of aging.
🚨New paper on theories of ageing. I discuss the major mechanistic theories of ageing in light of recent findings as well as the fundamental nature of the ageing process. Theoretical work is more important than ever in biology, including in ageing.
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Chemical cocktails for life extension.
Excited to share our new publication! We previously showed that age reversal can be achieved using transcription factor-based reprogramming. Now, we demonstrate that it can also be done with chemical cocktails to achieve lifespan extension!.
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