José Luis Ricón Fernández de la Puente
@ArtirKel
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Head of Theory at @RetroBio_ , enjoyer of things, blog: https://t.co/8xDYgWAJHB
San Francisco, CA
Joined April 2007
Only recently I came to accept this as a background fact in life: no matter how good, charitable, kind, or reasonable you (think you) are, someone out there, at some point, will inevitably misunderstand you, dislike you you, or find you annoying.
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The why is because he makes such a good vivid of each that's it's much easier to have the "ah yes I'm this kind of guy at times XYZ" with all of them whereas with other enneagram descriptions I tend to resonate with fewer.
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America’s first revolution wasn’t political—it was spiritual. The Great Awakening stirred faith across the colonies, challenged old powers, and planted the radical idea that liberty comes from God. Discover the revival that helped shape the American identity.
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Unless you are a very consistent or one-dimensional "kind of guy" I guess.
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Funnily enough reading through this very enjoyable series from Sasha Chapin (rest in substack) on the enneagram has made me more convinced that it's less useful as a people-typing system and more useful as a system to type someone "here and now"
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Play as adorable cat mages, fight through demonic hordes, and enjoy full Japanese voice acting in every story stage. New content drops weekly, with player-driven patches that actually happen.
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This is disappointing but not terribly surprising. The relationship between chronic caloric excess and Alzheimer’s pathology is not particularly strong so not that much reason to believe that putting people into negative energy balance would do much
Semaglutide (Ozempic) failed to have clinical impact for slowing progression in people with mild Alzheimer’s disease in 2 large, placebo-controlled trials https://t.co/NioLZxVad2
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New roles just dropped at https://t.co/wGMfQolof7 In Vivo Scientist, Osteoarthritis and Rejuvenation & In Vivo Scientist, Musculoskeletal Research
retro.bio
Our mission is to extend healthy human lifespan by 10 years.
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Now that DOGE has been shuttered, we can evaluate how it impacted government spending. The graph below shows total US government spending in 2025 vs. 2024 and 2023. Judge for yourself. https://t.co/uzbV6yPlZV
Exclusive: DOGE 'doesn't exist' with eight months left on its charter https://t.co/Ku9U9Lf94E
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Britain needs nuclear power. Our nuclear projects are the most expensive in the world and among the slowest. Regulators and industry are paralysed by risk aversion. This can change. For Britain to prosper, it must. Earlier this year, the Prime Minister appointed me to lead a
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CNEQ’s concentrated portfolio seeks the best opportunities in technology, automation, and digital transformation. Capture innovation, invest with conviction.
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Alexander Fleming's discovery of penicillin is unlikely to have happened in the way he described. It's almost certainly a myth. For decades, scientists and historians have puzzled over inconsistencies in Fleming’s story. The window to Fleming’s lab was rarely (if ever) left
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Today I am launching the Free Radicals podcast with @EricDai_BioE . Every Tuesday, we’ll be releasing long form conversations with the visionaries giving humanity control over biology and working to dramatically extend human lifespan. We’re thrilled to host @celinehalioua,
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Prompted by this longer survey
Let's compare our world models. I find that different people seem to have rather distinct internal world models. E.g. I personally have neither visual imagination nor an inner voice, found it weird others do. Here is a quick google forms to check idea:
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By this I don't mean "you can hear voices in your head" I can say anything in any voice at will in my head, or listen to music etc, but rather having it be relatively automatic and seemingly out of your control
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One thing I learned at this meditation retreat I just finished from talking to some other attendees is that my default state (no inner monologue, rarely having thoughts at all) is something many people actively seek through meditation! Do you have an inner monologue?
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Read Something Wonderful (about Biology) We just released a curated list of 125+ essays about biology and science. These articles cover pharmaceuticals, the history of molecular biology, timeless arguments and theories, and more. Check it out.🔻
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There’s a belief in SF that with enough money you can solve anything. For a lot of technical companies, VCs are therefore looking for a charismatic founder who they believe will be able to get that money. In the first few rounds, they care less about the actual technical
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Not yet enlightened and maximally self-accepting, but progress was made!
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There’s a new kind of startup in the valley: the Neolab. 9 of these 10 “neolabs” have $1B+ valuations at the seed. They’re all are likely <$10M in revenue and founded by ex-model lab AI researchers, many of whom have made $10-100M+ in personal wealth! What a time to be alive.
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