José Luis Ricón Fernández de la Puente
@ArtirKel
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Head of Theory at @RetroBio_ 🇪🇸➡🇬🇧➡🇺🇸
San Francisco, CA
Joined April 2007
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TIL astrology is real, if you work in semiconductors
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Isn't it kind of weird that teeth grow twice?
No teeth (0) seems normal.
Teeth once (1) seems also ok.
Teeth all the time (Infinite) like in sharks also seems reasonable.
Two (The default in humans) strikes me as a weird choice.
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Oh it's us!
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At dinner right now:
- can't eat pork, I'm Jewish
- can't eat chicken, because EA
- can't eat beef because Hindu
- can't eat tuna because mercury
But lamb brings us together
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A Thiel Fellowship, but to drop out of software and do something different.
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So far I have found ChatGPT useful for coding, and not much more. Is this everyone's general view?
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The best possible news for a US immigrant like me 🗽🦅🚀
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Elon Musk's secret life goal: To show that markets are way more inefficient than we thought by repeatedly making tons of money doing what various industries have strong economic incentives to do but don't do (reusable rockets, 10x cheaper batteries).
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Post Oppenheimer, someone outside the theater says "But he didn't invent anything, he just told people what to do... well I guess he picked those that did"
Indeed, the central thing of management. At worst, taking credit for other people's work. At best, dreaming into existence
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Probability of choosing STEM, SEH (Socsci&Humanities/Education/Health) and business, by SES and gender, in the US.
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There had been a longstanding debate in biosecurity circles whether one could synthesize smallpox from its sequence. One guy was like ayylmao and had it made (horsepox, as a proof of concept, protocol is the same for smallpox)
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Basically everything that has ever been said in the "science is broken" conversation (with some baseline plausibility; disaregarding for now relative importances):
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I have around 5000 PDFs and documents that I want to LLM through, what's the best current way?
ie I want to be able to ask things like "What do we know about X?" "Show me some documents that discuss Y" etc.
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I'm looking at google street view pics of San Francisco and it's surprising how low density the housing is. Madrid and SF have similar areas (see pic), yet Madrid has almost 4x the population.
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Wow Sam went through the Steve jobs arc so fast. At an accelerated pace dareisay
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How it started (Feb 2020), how it's going (Oct 2021). Thanks
@asterainstitute
&
@BuckInstitute
for making it possible!
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Tired: Covid was a Chinese bioweapon
Wired: Covid was orchestrated by the GMU Econ department to a) increase preparation for future serious, Spanish flu-tier pandemics and importantly b) increase economic growth by accelerating the transition to remote
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For a while everyone was like "But partial reprogramming has never extended lifespan in wild type mice". Now it has (As I expected it eventually would):
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Cool-shit futurism (space colonization, moon telescopes, tech for the sake of tech to some extent) vs cozy futurism (urban reform, renewable energy, solving climate change; focusing on specific problems and having tech as an ends) are categories I've been thinking about recently
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Today is my first day at
@RetroBio_
!
Excited to join an amazing team working on therapies to extend healthy human life :))
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Has topology gone too far?
(via Mathematical Mathematics Memes)
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Today I turn 30. Reply with life advice for incoming decade.
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@marannelson
@josaaay10
My TSA shitpost was when they asked me the "Why are you coming to the US" I replied "To make science great again", he loled and let me through
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No sequencing? No problem! You can shoot lasers at cells and read their transcriptomes at a single cell resolution (ht
@AlexandreTrapp
)
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The covers of Cell Metabolism are amazing
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There's a gigabrain post to be written that starts from the observation that there are potential Feynmans trapped in Jane Street, continues with the suggestion that finance should be taxed and finishes arguing that that's the highest leverage metascience intervention.
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I wrote an article for a new publication,
@helloflink
on the road towards beating aging and what deep changes it may involve to our lives looking far into the future.
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"Bringing the scourge back would probably take a small scientific team with little specialized knowledge half a year and cost about $100,000."
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Strong chad energy in this fire commander
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@webdevMason
It's reaching levels of lol that wouldn't be believable if done for comedy reasons in a sitcom.
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The unreasonable effectiveness of doing, then thinking; vs thinking too much before doing
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To my taste,
@dwarkesh_sp
is probably the best podcaster there is right now. Both he and
@tylercowen
research their guests in depth and try to ask novel questions. But Dwarkesh is more serious about intellectual exploration (at the expense of cultural aspects)
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Form I-140 approved today!! One step closer to the green card 🚀
Took ~ 11 months for an EB2-NIW
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After a year of working with the great team at
@meet_aiden
, followed by another year at
@twitter
(keeping and growing the same team!) post-acquisition, I'm leaving tomorrow and moving to SF in early November to -checks notes- make science great again. Exciting times!
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Artificial wombs may sound weirdly dystopian but it's an equalizing and liberating technology which we should have.
we’re not even close to full-term artificial wombs. the tech’s *theoretical* value prop is saving premies. if you’re worried about population collapse my suggestion is to have a baby.
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Why is search on Mac hilariously bad? You're on a folder, search something (On Finder) and then it does a full disk search that somehow it manages not to find the file. WTF
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Ok, cashed out of $GME this morning. Farewell to our fellow cosmonauts headed to deep space for an uncertain voyage.
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Consider a parrot. Compare how likely you think a parrot is conscious* with how likely you think LLMs are conscious. A parrot will never be able to produce output like LaMDA. And yet the parrot is orders of magnitude more likely to be conscious.
(*is a subject of experience)
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@StuartJRitchie
@hamandcheese
The only real thing here is Stuart coming out as aphantasiac 🙃
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What do researchers in the aging field believe? A survey
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@juliagalef
"Galef CONFESSED to her dislike of standard journalistic practice, sources closer to the author said"
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re that cancer cure, this is not the first time something like this happens. Killing multiple cancer cell lines while sparing normal cells is something that we've seen before with eg 6-thio-2'-deoxyguanosine or MR1 CAR-T. The hard thing is making it work in vivo, in solid tumors
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The perfect floor lamp hasn't been inven—
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[Marked safe from Forbes 30 under 30]
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I recorded a podcast on longevity, fixing science and assorted topics, it's now available:
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Related: I think this is why LLMs are for now overhyped. Software engineers are rightly impressed (as they use them day to day). Many others are like rightly unimpressed. But because a lot of the discourse comes from software land, it seems everyone finds them super useful (?)
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I have become one one with Twitter!
@meet_aiden
has now been acquired by Twitter, making me a capital-t Tweep.
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@kulesatony
DeepMind has teams competing with each other following different approaches to the same problem. There are leaderboards. Winning team absorbs the rest, then everyone works on the promising approach.
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Today in "WTF I can't believe that valuation", Linktree is valued at over 1.3bn dollars.
For a link to a list of links.
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The opposite is true! Programming is joyful because feedback is solid and fast!
programming is frustrating because when your mental model is incorrect, feedback is fast and impossible to refute
other tasks are don't feel as frustrating because incorrectness doesn't punch us in the face like in programming — but that doesn't mean we're any less wrong 🙃
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This restaurant is spicy in multiple ways
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Tfw you try to get GPT3 to solve aging
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Get your blood tested randomly! Your doctor will not do this for you but it can be really helpful. I found out I was vitamin D deficient (and started supplementing). A while back I found out my blood iron was too high. I had assumed I got enough sun because Bay Area but wrong.
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Telomeres: everything you always wanted to know
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Tools for thought, half a century of trying to get adoption, half a century of failing. There's a need for a meta-literature on not how people decide, think, or remember, but on why they or do not adopt tools to help them do that. Retention remains a substantial issue.
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When I see someone writing their name as 'X, PhD' I reduce my prior somewhat that what they are about to say is true. Is this generalized?
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Reminder that if you liked Jiro dreams of sushi you must watch juan likes rice & chicken
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The Pyramid of Economic Insight and Virtue, now in meme form. From
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Confused about what FROs are? I made a handy chart for reference
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Stoicism: Marie Kondo but for feelings
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Probably the most SF injury possible is dropping a chonky tungsten ball on my finger
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Solving aging means little if that doesn't include brain aging! Retro is going deeper into CNS territory, we just hired a Head of CNS!
Reach out if brain rejuvenation is of interest! :)
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I worked at Twitter in 2019.I have seen the codebase, processes, documentation etc.I do think the company can do with substantially fewer headcount and be the kind of thing that well managed takes on facebook and tiktok. As a twitter enjoyer, I hope
@elonmusk
makes that a reality
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One way to think about the repeated failure of AI in bio is this: The way of AI is 'design intelligent systems that can solve the problem for you'. The way of bio is 'Try everything in parallel'. They both try to push away 'first-principles thinking' (the way of the mathematician
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Why is partial reprogramming (Iduna, Altos, Retro, Turn, NewLimit) so interesting? (1/n)
Altos Labs came out of stealth today with $3 billion in funding.
Mission: unravel deep biology of cellular rejuvenation programming
Funders: They don't disclose ((only ARCH))
Full list of the scientists that joined is here.
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Biology research is wild: You find a really impactful paper that has tried [a thing] and it is not rare that that paper, even if published a few years ago, is the only time mankind has ever tried that particular thing (At least publicly).
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The key difference between a date and a zoom date
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I've heard various people calling for more optimistic sci-fi. But what are good examples of optimistic sci-fi? (Other than Star Trek). I tried searching for it and most movies didn't seem particularly optimistic. Tomorrowland is probably the closest. What else?
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Guys, this is getting out of control
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Using nuclear weapons to study the brain
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So basically Tesla has out-NVIDIA'd NVIDIA as well as the entire crop of ML chip startups like Cerebras or Tenstorrent.
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Update: is sort of operational. You can pick a paper (e.g. search in semanticscholar , take the id, paste it in my website and it gets you all relevant systematic revs or meta-analysis that cited that paper)
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At last, an exowomb* company. They have raised 100M or so:
*Also known by their less cool name artificial wombs
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