1/8 . Why does eating less extend lifespan? 🧬. We often think about saving energy or recycling waste - but we show how evolution acting on mutation load can generate longer life on low food 🧵. and preprint below:. 🔗

Short experimental heatwaves have sublethal impacts on male reproduction in a model insect

RT @agingdoc1: Psilocybin treatment extends cellular lifespan and improves survival of aged mice. 👉 “We provide the first experimental evid….

RT @OdedRechavi: Pending editorial decision

RT @prof_horvath: Challenging a longevity dogma in muscle aging. Validated epigenetic clocks (pan-mammalian and muscle-specific) reveal a s….

RT @prof_horvath: Disappointing results continue to accumulate in longevity research regarding efforts to remove or replace aged blood plas….

RT @jpsenescence: Can senolytics slow aging?. Recent clinical trials and the largest mouse study of senolytics to date have failed to suppo….

RT @agingdoc1: German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway. .

RT @AntebiLab: 1/7 Out now @NatureAging🚨 We identified a genetic network of TFEB, TGFβ and NOTCH signaling regulating stem cell resilience,….

RT @AlexeiMaklakov: Nematode mind: exploring the role of the RNA interference pathway in learning, memory and beyond | Philosophical Transa….

Avian Lifespan Network Reveals Shared Mechanisms and New Key Players in Animal Longevity - Martini - Aging Cell - Wiley Online Library

RT @OVincze_: Studying cancer across species can reveal new ways to understand and potentially treat cancer. Together with leading experts,….

RT @melikedonertas: Exciting update! We will provide #TravelGrants to support selected early-career researchers presenting their work (talk….

Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch | Science

Updated version:

Nematode mind: exploring the role of the RNA interference pathway in learning, memory and beyond | Philosophical Transactions of the Royal Society B: Biological Sciences

8/8.Possible to modify gene expression in fully-fed for DR-level longevity without fitness costs. Graphic by @zahidasultanova.

7/8.More important to live longer when current reproduction is low, than when current reproduction is high. No trade-offs are necessary, just Hamiltonian forces of selection.

6/8 .This is a very general result – applies to every stress that suppresses fertility – thus can explain every form of hormesis – when mild stress reduces reproduction but increases lifespan.

5/8.Works with different genes acting in different environments, or when gene expression differs between the environments 📉.

4/8.Our analytical model shows DR-driven lifespan extension evolves because DR suppresses fertility—this strengthens selection against mortalitycompared to full feeding environment