Been working on a really strange retron bacterial immune system, here's the preprint: https://t.co/iWP8qH1Fe7 Type VI retrons are unlike any other. Phage infection triggers reverse transcription of a DNA fragment that activates translation of a toxin to kill the infected cell.

It was great fun to have mentored an amazing summer intern, Kazuo Nakamura, through this project, and to work alongside wonderful scientists @matromont and @pentamorfico, with invaluable guidance from @seth_shipman.

Six new retrons just dropped! See how we isolated these cool bacterial immune systems from the wild in our latest preprint. From soil to sequence, we uncover the operons of these novel retrons and their phage defense properties. As a bonus, we repurpose them for genome editing 🧬

PhD student --> candidate ✅

*Preprint Alert* This one’s in a new area for the lab: phage editing! We're using retrons to produce recombineering donors ~inside~ bacterial hosts. A wild-type phage infects the host and an edited phage comes out.

We look towards a future of nanopore protein sequencing when single-molecule meets single-cell. scPeptide-barcoding, full-length protein reads, and “near-pore” processing…

Check out our new review/opinion on molecular recording of transcriptional events by @sierra_lear. We write about where the field is, where it might be going, and what's stopping us from being there now.

Hear me out — my convo with @royanaieni is an all-time fav. Instead of trying to solve ONE specific disease, she’s making genetic engineering easier for everyone with robot arms! Pod: https://t.co/tcNJ6mnUXZ Apple: https://t.co/hSOaXtE7k3 Spotify:

Proud to have worked with the wonderful @yuanjc08 and @jeffnivala, without whom this project would never have taken flight. Also many thanks to @seeliglab and the folks @datamolecules for their helpful advice and support!

The art of molecular computing expands further… Out now in @NatureComms: Synthetic DNA circuits can be directly detected, kinetically characterized, and multiplexed beyond fluorescence-based reporting capabilities - all on a @nanopore platform! https://t.co/egnvXCVkSo

"Voyage through Time" is my first artpiece using #stablediffusion and I am blown away with the possibilities... We're crossing a threshold where generative AI is no longer just about novel aesthetics, but evolving into an amazing tool to build powerful, human-centered narratives

I’m excited to introduce our Retro-Cascorder, out today in @Nature! This molecular device logs barcoded receipts of gene expression in a temporal genomic ledger. Sequence the ledger --> recover the history of gene expression.

Online @nature is DNA Typewriter, a molecular recorder that allows for time-resolved recording of sequential events https://t.co/VabRxGxSrH

In @ScienceMagazine we describe how a CRISPR-based bacterial recording system (Record-seq) captures signatures of diet, disease, and microbial interactions within the intestine – helping us understand how diet, disease, and the microbiota shape health. 1/12

Year end buzzer-beater preprint! We present a new readout method for DNA strand displacement reactions using @nanopore arrays: A nanopore interface for high bandwidth DNA computing

Other highlights include: visualization of circuit kinetics by quantifying barcode capture frequency, and multiplexed detection of SNVs in miRNAs for disease diagnostics. Many thanks to @jeffnivala and @yuanjc08 for their unending supply of advice and wonderful ideas!

Introducing... parallel DNA computing on nanopores! Output strands from DNA circuits contain a barcode and biotin mod, enabling real-time readout by a nanopore sensor w/o sequencing. Dozens of unique barcodes can be detected in one rxn. Our new preprint: https://t.co/YBhudUnMEQ

Neural networks dream of electric Proteins 🐏🐑🐏🐑🐏🐑 now with experimental validation 🥳 https://t.co/LBBgC3BcvM

The 2nd International BioDesign Research Conference