In @NatRevGenet we outline strategies for in vivo pooled (single cell) CRISPR screens for genotype → phenotype mapping in animal models. This contains over a decade of hard earned knowledge by us and the field. Kudos to @AntonioSantinha & Alessio Strano. https://t.co/xtSjG7Ep4v

Just under one week to apply for this Research Technician position.

🚨 Computational postdoc Job alert 🚨We are recruiting a postdoc to focus on the development and application of computational methods for functional genomics. Come join us in Basel, Switzerland! More info at:

🚨Job alert 🚨We are recruiting a Research Technician, primarily with skills in molecular and cellular biology. Come join us in Basel, Switzerland! More info at:

New online! Methods and applications of in vivo CRISPR screening https://t.co/gZTqRCrLBa

In vivo CRISPR screens offer a unique way to study gene function at scale🐁. In our new @NatureRevGenet article, Alessio Strano, @randall_platt, and I review current methods, experimental designs, and explore exciting future directions! https://t.co/L1HGdoEgks @ETH_en @ETH_BSSE

I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!

👏🏽 Big congrats to Costanza Borrelli who studied cell-cell interactions in the Lab of Andreas Moor, and Antonio Santinha from @randall_platt Lab, inventor of a novel technology for single-cell CRISPR screening, received the 2024 @ETH_en Medals🤩 > https://t.co/SNee0KCejL

🚨Job alert🚨 We are recruiting a PhD student to work on the development of high-throughput protein perturbation technologies. Come join us in Basel, Switzerland! More info at:

I'm looking for a research #technician to help discover on how cells remove organelles. Are you skilled with #CRISPR, flow cytometry, and primary cell culture? Please apply!

@randall_platt @olivier_belli @k_karava @ETH_en @ETH_BSSE @BRC_CH @UniBasel @NCCR_MSE Precision mutational scanning: your multipass to the future of genetics - @naturemethods N&V by @fjsanchezrivera

The success of AI applied to drug discovery is being decided by a number of clinical trials. So far, the results are lackluster. Why? For AI to have a transformational effect in drug discovery, training data must come from living mammals. (🧵1/9)

@randall_platt @olivier_belli @k_karava @ETH_en @ETH_BSSE @BRC_CH @UniBasel @NCCR_MSE Using CRISPR to decipher whether gene variants lead to cancer #NBTintheNews via @ETH_en

Researchers at ETH Zurich have combined two #GeneEditing methods. This enables them to quickly investigate the significance of many #GeneticMutations involved in the development and treatment of #Cancer.

Using #CRISPR to decipher whether gene variants lead to #cancer - research from the Biological Engineering Lab of @randall_platt, published today @NatureBiotech

One of the major challenges in human genomics is the functional assessment of variants. Base and prime #CRISPR genome editing is making a big difference for meeting that challenge, as exemplified in this new report @NatureBiotech https://t.co/he8oGniSrM @randall_platt

Multimodal scanning of genetic variants with base and prime editing https://t.co/S2poPOSxQR

Exciting research on using #CRISPR to decipher whether gene variants lead to #cancer and advancing base and prime editing tools by @randall_platt @ETH_en >

And here is an open link to the paper:

Today in @NatureBiotech we report on the use of base and prime editing for high throughput interrogation of genetic variants in cancer. Excellent work by first authors @olivier_belli & @k_karava. 🧵👇 https://t.co/SEomr7ubwR @ETH_en @ETH_BSSE