SKlaeger
@susanklaeger
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Joined October 2018
We report a new role for HIF in the regulation of endogenous retroviruses! It was a big collaborative effort to explore the HIF-mediated transcription, expression, and HLA presentation of ERVs in kidney cancer and leveraging them for immunotherapy https://t.co/0Qpox9xWG2
cell.com
An upregulation of the HIF2 transcription factor, which is a hallmark of the most common form of human kidney cancer, drives the expression of multiple relatively intact endogenous retroviruses,...
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Transforming traditional views laid by “CNS immune privilege,” our research uncovers the brain’s purposeful presentation of self – that is the brain engages with the immune system through “guardian” peptides to ensure immune tolerance. @jonykipnis
https://t.co/XRr11LC82M
nature.com
Nature - Central nervous system (CNS)-derived regulatory self-peptides are essential for maintaining a continuous dialogue between the CNS and the immune system while balancing overt autoreactivity.
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BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation https://t.co/59cWJy9MXH
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Since many people were interested in implementing our workflow for deep coverage #immunopeptidomics, we wrote a comprehensive and detailed protocol. Available now via @researchsquare
https://t.co/MssBxs9lr9
#proteomics
researchsquare.com
Major histocompatibility complex (MHC, or Human leukocyte antigen, HLA) peptide ligands can be exploited to develop immunotherapies targeting immunogenic disease-specific immunopeptides, such as...
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Very excited to see work from Hanna Budayeva included in this special issue of @JProteomeRes. Hanna has done a fantastic job leading our chemoproteomics efforts over the last few years - this story is just one of the exciting things her group is working on! Check out this issue!
The latest issue of Journal of Proteome Research is live! On the cover: "Celebrating Women in Proteomics and Metabolomics" Read it here: https://t.co/c7TgOWZfMo
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Very exited to share this preprint. Great work by @oliinyk_denys and Hem Gurung, and thank you to all authors!
Very nice to see the result of my internship at @genentech out in @biorxivpreprint! If you’re intersted in diaPASEF and immunopeptidomics, check this out: https://t.co/erUitvtb92. Big thanks to @susanklaeger and @CMichaelRose for introducing me to immunopeptidomics!
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For those looking for a new proteomics opportunity, there is a position open within the Translational Medicine group. This is a fantastic opportunity to perform impactful research using cutting edge technology. Check it out below! https://t.co/VFoXokQP6X
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Our Proteomic and Genomic Technologies department has 14 presentations across oral & poster sessions and breakfast & evening workshops at #ASMS2024. Very grateful to work with many talented researchers & very excited to share our research next-door to the happiest place on earth!
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We preset an approach to test phosphorylation site function in high throughput. Like phenotypic CRISPR screens but instead of knocking out a gene, we mutate specific codons with base editors so the resultant protein cannot get phosphorylated that site.
New from @SAMyers_lab! Combining genome-wide CRISPR–Cas9-mediated base editors with temporally resolved phosphoproteomics enables the functional screening of thousands of post-translational modification sites involved in T cell activation. https://t.co/EtEoofQt8A
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Bay area proteomics friends - Having some ASMS FOMO? Or just want to pregame for ASMS? Come attend our @QBI_UCSF and @rezo_tx Mass Spectrometry Symposium at UCSF on Thursday May 30, hosted by myself and Chris Adams. We have a diverse and spectacular lineup https://t.co/GkKhTTdSNa
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The deadline for abstract submission has been extended to April 9th. Please submit your abstract using the link provided below. #immunopeptidomics @hupo_org #proteomics @HippHupo
Save the date! The 3rd HUPO-HIPP summer school. Université de Montréal, Canada August 14th to 16th 2024. @hupo_org #immunopeptidomics #HLA
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Interested in learning more about immunopeptidomics? Join us this summer in Montreal for the 3rd HUPO-HIPP summer school:
Save the date! The 3rd HUPO-HIPP summer school. Université de Montréal, Canada August 14th to 16th 2024. @hupo_org #immunopeptidomics #HLA
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#proteomics ⚖️, #datascience 📊 or #programmers 🧑💻? We are looking to fill a staff scientist position centered around ProteomicsDB. More details available here:
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Check out this great resource on shared cancer neoantigens.
Excited to share the publication of a large collaborative effort @genentech to discover shared cancer neoantigen neoepitopes. From 47 cancer neoantigens and 15 HLA alleles we discovered 86 neoepitope-HLA pairs, 65 were novel at acceptance - check it out!
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BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
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Do you want to get as much data as possible out of your limited tumor samples? Well now you can with our MONTE workflow! Our manuscript describing the serial enrichment of immunopeptidome, ubiquitylome, proteome, phosphoproteome and acetylome is out now!
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TODAY is the day! Join the #HUPOECR, at 5PM GMT, for a discussion panel on non-academic pathways in proteomics, with panelists @CMichaelRose @lkpino and Maria Polychronidou (@MolSystBiol) ⭐ You can still register here: https://t.co/WxdFOEBfCm
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Our review discussing methods to detect novel antigen types in cancer is out today. The peptide woods are lovely, dark and deep: Hunting for novel cancer antigens.
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Do you or someone you know do proteomic mass spectrometry AND molecular biology? Then come join me and the amazing folks at Vertex! #chemjobs #teammassspec
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