Broad Proteomics
@BroadProteomics
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Broad Proteomics official twitter account @broadinstitute of @MIT and @Harvard
Cambridge, MA, USA
Joined June 2021
We report a new role for HIF in the regulation of endogenous retroviruses! It was a big collaborative effort to explore the HIF-mediated transcription, expression, and HLA presentation of ERVs in kidney cancer and leveraging them for immunotherapy https://t.co/0Qpox9xWG2
cell.com
An upregulation of the HIF2 transcription factor, which is a hallmark of the most common form of human kidney cancer, drives the expression of multiple relatively intact endogenous retroviruses,...
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Check out our new work led by @aliceyting and her lab presenting LaccID for peroxide-free labeling of cell surface proteins for PL-proteomics and EM applications.
APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2
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Excited to share our latest manuscript dedicated to the remarkable Donald F. Hunt, a true pioneer in the field of mass spectrometry and O-GlcNAc research! From Fringe to the Mainstream: How ETD MS brought O-GlcNAc to the masses
mcponline.org
O-GlcNAcylation was identified in the 1980s by Torres and Hart and modifies thousands of cellular proteins, yet the regulatory role of O-GlcNAc is still poorly understood compared to the abundance of...
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Glad to share our latest study on the cell-surface proteome of human dendritic cells, by our awesome long-term collaborators Namrata and Charles @BroadProteomics and talented undergrad @Zuzhi_Jiang (soon at @UCSF tetrad for PhD). https://t.co/e4jGWJHoqu
academic.oup.com
The JI publishes peer-reviewed manuscripts describing novel findings in all areas of experimental immunology, including both basic and clinical studies.
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#TeamMassSpec - My undergrads have created some tutorials for learning mass spec from a computational point of view (not a chemistry point of view). If you're looking for some #FridayFun, take a look and let me know what you think. https://t.co/K7jO8l8eZd
github.com
Contribute to PayneLab/ProteomicsEducation development by creating an account on GitHub.
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🔬 Opportunity alert! Seeking a talented candidate with tissue imaging experience for the fascinating field of spatial proteomics at @broadinstitute . Feel free to apply or direct queries to @shankha_ss. #jobs #proteomics #imaging #microscopy
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In three new pan-cancer studies, #CPTAC researchers have harmonized data on proteins, DNA, and RNA, together with clinical data from more than 1,000 patients to uncover ways in which proteins are involved in important cancer processes. https://t.co/PCcfH9e25Z
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Please check out new work from @aliceyting and all co-authors using PL methods to study protein trafficking. Another fun and exciting collaboration with Alice and the entire team. @BroadProteomics
TransitID is out today in Cell! This is a proximity labeling method for unbiased discovery of endogenous proteins that traffick from a defined “source” location to a defined “destination” location. TransitID uses sequential labeling by TurboID in the source, followed by a chase
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If you’re at #ASMS2033 this week come check out these talks and posters by members of the Broad Proteomics Team!!
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This was a major team effort and we thank our funders #cptac #amrf and everyone @BroadProteomics who contributed to this manuscript! @jenn17grace @namude @shankha_ss @susanklaeger @Krivera23 @broadinstitute @NatureComms
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Do you want to get as much data as possible out of your limited tumor samples? Well now you can with our MONTE workflow! Our manuscript describing the serial enrichment of immunopeptidome, ubiquitylome, proteome, phosphoproteome and acetylome is out now!
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Our 9th most downloaded article in 2022: Cancer proteogenomics: current impact and future prospects by @shankha_ss @mani_d_r & Steven A. Carr & colleagues https://t.co/QSjsMeEGab
@NatResCancer @BroadProteomics @broadinstitute @bcmhouston @WUSTL #NRCtop10of2022
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A #Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas, by @lisacervia, Tsukasa Shibue, @DrFranVazquez, Bill Hahn et al. https://t.co/HSDqp3zqaz
@broadinstitute @DanaFarber @CancerDepMap
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Congrats to Steve and Namrata for making it to this list.
Proud to be named a Highly Cited Researcher 2022 by @ClarivateAG. See the full list https://t.co/fVWWHj4FKI
#HighlyCited2022 (though they got my affiliation wrong :| )
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Please check out our latest pre-print showing how proteomics and other omes are integrated to understand mechanisms underlying exercise biology. This was a tremendous collaboration and effort across many institutions. @PierreMichelJ10 @HasmikKeshishi1
We are thrilled to share the preprint for the Molecular Transducers of Physical Activity Consortium’s (aka MoTrPAC) first major multi-omic multi-tissue exercise study and data resource!
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The study of proteins is more than just a research tool — Broad researchers are showing that it has potential to impact patient care, too. Learn about clinical proteomics at Broad in a feature story: https://t.co/73jF3tpPL2 (1/3)
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Proteogenomic Markers of Chemotherapy Resistance and Response in Triple-negative #BreastCancer, by @MeenakshiAnurag, @shankha_ss, @DrMJELLIS et al. https://t.co/HAr44mEdm9
@bcmhouston @BCMCancerCenter @BroadProteomics @broadinstitute #TNBC #CPTAC
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