Preethi Srinivasan
@srinipr4
Followers
87
Following
617
Media
0
Statuses
53
Joined May 2013
Published today! We used targeted #MSKimpact tumor sequencing data to infer genetic ancestry and identify associated somatic features in ~50,000 patients. Lots of interesting methods and findings, but I will focus on one. 🧵 @MSKCancerCenter (1/10) https://t.co/wdH1aMm6hX
aacrjournals.org
Genetic ancestry inference in a clinical pan-cancer cohort of 45,157 patients enabled discovery of ancestry-specific differences in the frequency of somatic features and the prevalence of clinically...
5
75
269
Online today! More to say later, but for now huge congratulations to @kanikaarora316 @chaiband @CDebyaniPhD and everyone involved in this important research! #MSKimpact @MSKCancerCenter 🧬
Now online in @CD_AACR: Genetic Ancestry Correlates with Somatic Differences in a Real-World Clinical Cancer Sequencing Cohort @MFBerger1 @MSKCancerCenter #cancerdisparities
https://t.co/T1kA3xmELh
2
23
65
And check out the new portal that goes with this paper: https://t.co/bgWF0kbs7k! Think of it like @gnomad_project but for germline variation in cancer. It was a pleasure building this with @chaiband @srinipr4 @MFBerger1 @BarryTaylorLab and our usual posse @gaojj, Onur and Xiang
We are excited to share a new portal for integrated somatic and germline interpretation. https://t.co/Cg6eHCR73v. Thanks to the phenomenal scientific engineering team led by @gaojj with @inodb, Onur Sümer, Xiang Li. 15/n
1
8
15
Very excited to see this finally out! Incredibly grateful and proud to share this work which has always been very close to my heart!
Proud to share our work out today in @NatureGenet. With @srinipr4, @MFBerger1 and @BarryTaylorLab. https://t.co/fyHjvxDbpe We try to understand the extent to which cancers arising in patients with inherited pathogenic variants are actually mediated by the germline defect, 1/n
4
2
20
Following the departure of four stellar postdocs (@huzheng1, @caswell_jin, @seoaneja, Kasper Karlsson) who have launched independent careers in the past year, the Curtis Lab ( https://t.co/WqFoOA8gPN) is recruiting postdocs and computational staff scientists.
med.stanford.edu
1
40
55
Happy to share my Feature Article @eLife — a call to expunge non-inclusive terms to make science inclusive for all #inclusivescience #EDI #scicomm #AcademicTwitter
https://t.co/tEm4wGUHt2 🧵⬇️
4
57
139
Our (co-inventors @McLellan_Lab) COVID-19 vaccine (spike delivered by @moderna_tx's mRNA) was just injected into the 1st human in phase 1 trial, only 66 days after viral sequence release... a testament to rapid vaccine development for emerging diseases🦠💚 https://t.co/2DLZsdirAD
niaid.nih.gov
A Phase 1 clinical trial evaluating an investigational vaccine designed to protect against coronavirus disease 2019 (COVID-19) has begun at Kaiser Permanente Washington Health Research Institute...
577
4K
17K
🚨Urgent🚨@StanfordMed @StanfordHealth is performing 1000 tests for #COVID19 a day for Bay Area hospitals, but is running low on critical reagents. If your lab is in the area and can donate any of the following please DM. Thank you!
22
322
337
The Biogen cluster is a cautionary tale for anyone still considering conferences/large meetings over the coming weeks. At this point we all have enough information. Organizers: cancel/reschedule/go remote, or any transmissions are on you.
bostonglobe.com
Amid ominous signs after a routine conference, a frightening realization slowly dawned: The virus was on the loose.
5
119
205
Our paper is out! 😊 Showcasing the complexity of #mutationalsignatures A practical framework and online tool for mutational signature analyses show intertissue variation and driver dependencies @NatureCancer 👇 1/
11
79
242
Great tweetorial from my new colleague Sebas. Check out his new work CNApp!
Big news! Our paper presenting CNApp accepted for publication in @eLife!! https://t.co/bI2dSbEKGR CNApp is hosted at https://t.co/B6OBgICrQr. I am opening a thread to briefly explain our work… Let’s go! (1/13) #science #paperpublished #eLife #CNApp
0
1
2
Looking back as this decade is coming to a close: cBioPortal went from 4 cancer studies to >200, and we added countless new features. Thanks to #opensource, #TCGA, #NCIITCR, #HTAN, @AACR, @PCF_Science, @SU2C, @BCRFcure. Travel back in time @waybackmachine: https://t.co/kGQY5ndt1T
0
29
90
Ever had an MMR-P cancer turn out to be MSI-H and have no explanation? Read our brand new systematic analysis on the sensitivity of MMR IHC in a pan-cancer cohort of 443 MSI-H tumors in @ModernPathology : https://t.co/z3QcmmiXYq Example and take home points below 👇
4
49
83
Great figure illustrating mechanisms of resistance to CDK4/6i form Dr. Jeselsohn #SABCS19 from @DanaFarber #bcsm
0
1
10
This week at #SABCS19, MSK investigators shared the latest in #breastcancer detection and screening, immunotherapy, and the underlying causes of resistance to targeted therapies, among other topics. Catch up here.
mskcc.org
About two dozen MSK physicians and researchers shared their work at the world’s leading breast cancer conference, held annually in San Antonio.
0
4
12
Perspective: Machine learning has the potential to be extremely useful in medicine, particularly in the interpretation of medical images. But it also has inherent limitations, especially when it comes to diagnosing early-stage cancer.
5
105
184
Major @OncoKB release & milestone people! We've now curated >5000 cancer alterations! & added a registration option (if you want to download data or use our API) to let us get to know our @OncoKB community better. Visit https://t.co/SNyjsesSz8 or via @cbioportal & stay tuned!
1
14
49
