Barry S. Taylor
@BarryTaylorLab
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Cancer scientist
New York, NY
Joined June 2017
Strange and vague sense that, in these times, this may be misplaced. But the superlative efforts of @alexgorelick deserve no less: Doubling down, an unexpected cancer gene story in @nature today, a thread 👇🏻 [1/n] https://t.co/7vIayNhB71
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A testament to the power of grit, creativity, and collaboration on the part of the amazing @srinipr4 and @chaiband. Congratulations to the entire team and especially @MFBerger1 for being a wonderful collaborator and colleague throughout this long journey. https://t.co/nEu0eyC0aD
Proud to share our work out today in @NatureGenet. With @srinipr4, @MFBerger1 and @BarryTaylorLab. https://t.co/fyHjvxDbpe We try to understand the extent to which cancers arising in patients with inherited pathogenic variants are actually mediated by the germline defect, 1/n
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A new preprint from @alexgorelick, @mito_oncogene, and my lab describes our labor of love to understand mtDNA mutations in cancer. Wow did we learn a lot. A few highlights:
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Nice piece on @CD_AACR today about the relevance of multiple mutations in the same genes. Summary of different stories recently published. @sloan_kettering @BarryTaylorLab @baselga1 @kataoka_lab
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Just out on @NatureCancer a brilliant review on the scientific discoveries promoted by clinical sequencing of tumors, from the @sloan_kettering group Many challenges ahead to optimize cost & accessibility of seq tech - but we’re moving fast @OncoAlert
https://t.co/TdO7iz527N
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1y ago today: @AACR #MBCO - incredible networking session w/ @rosslevinemd @DKirschMDPhD @DSolit @carlhjune @BarryTaylorLab + many more. Miss this group. #COVID19 has altered how we meet, but has NOT altered the importance of amazing colleagues/friends who brighten our lives!
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In silico modelling can distinguish functional from benign #MAP2K1 and #MAP2K2 mutants but can’t explain variabilities in #DrugResponse, Hanrahan et al report: https://t.co/lHsmGTiKxV
@sloan_kettering @AmberKiliti @moriahgabrielle @alexshoushtari @abdelwahablab @DSolit
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Great thread from former ACS grantee @BarryTaylorLab, whose new study reveals the prevalence and level of complexity of composite mutations in cancer, providing an eye-opening experience especially when the two mutations occur in a single copy of a gene.
Strange and vague sense that, in these times, this may be misplaced. But the superlative efforts of @alexgorelick deserve no less: Doubling down, an unexpected cancer gene story in @nature today, a thread 👇🏻 [1/n] https://t.co/7vIayNhB71
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Looking forward to highlighting some of the collaborative efforts of hundreds of clinical, translational and basic researchers @sloan_kettering who seek to leverage a deeper understanding of tumor biology and genetics to identify more effective and less toxic cancer therapies.
Today at 4:30pm, @DSolit will be leading an #MSKScienceSpotlight about “Defining the Actionable Cancer Genome.” Stream it live here: https://t.co/Txm2GXOf5Y
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Huge congrats to Ed @EdReznik, Barry @BarryTaylorLab , and Alex @alexgorelick! Was great to see this project evolve from conception to stellar final product @sloan_kettering!
The second paper from the lab, this time with the fantastic @alexgorelick and @BarryTaylorLab on the role of composite mutations (2+ mutations in the same gene, in the same tumor), out today in @nature
https://t.co/dR8s0jY4Et A thread on my thoughts... [1/n]
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Online @nature Phase and context shape the function of composite oncogenic mutations https://t.co/kpZYTrvkWA
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Superb @nature paper by @alexgorelick (need a postdoc anyone?) co-mentored by @BarryTaylorLab & @EdReznik. Nearly 1 in 4 tumors hv composite mt & are often a combn of less common hotspots e.g PIK3CA composite mt in breast cancer (see @VasanNeil paper https://t.co/gt6DGGFeES)
Strange and vague sense that, in these times, this may be misplaced. But the superlative efforts of @alexgorelick deserve no less: Doubling down, an unexpected cancer gene story in @nature today, a thread 👇🏻 [1/n] https://t.co/7vIayNhB71
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Congratulations @EdReznik @BarryTaylorLab - fantastic work on an important topic in cancer genomics. Major implications for epistatic interactions between mutations. #mskimpact @MskccCMO @CompOncMSK
The second paper from the lab, this time with the fantastic @alexgorelick and @BarryTaylorLab on the role of composite mutations (2+ mutations in the same gene, in the same tumor), out today in @nature
https://t.co/dR8s0jY4Et A thread on my thoughts... [1/n]
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"We’re looking at a phenomenon that’s been staring people in the face for a long time." Finding driver mutations may be more complicated than was previously thought, according to a new @nature study by @BarryTaylorLab, @EdReznik, & @alexgorelick.
mskcc.org
Discovery reveals that the genetic causes of cancer may be more complicated than previously thought.
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Stellar work by @alexgorelick and @BarryTaylorLab out today in @nature. A true privilege to have contributed (just a little) to this paper.
Strange and vague sense that, in these times, this may be misplaced. But the superlative efforts of @alexgorelick deserve no less: Doubling down, an unexpected cancer gene story in @nature today, a thread 👇🏻 [1/n] https://t.co/7vIayNhB71
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The second paper from the lab, this time with the fantastic @alexgorelick and @BarryTaylorLab on the role of composite mutations (2+ mutations in the same gene, in the same tumor), out today in @nature
https://t.co/dR8s0jY4Et A thread on my thoughts... [1/n]
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Online at @nature: "Phase and context shape the function of composite oncogenic mutations" by @BarryTaylorLab and colleagues https://t.co/XLj2Fs0WY4
#Cancer
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And congrats to @kataoka_lab for their excellent work on the same topic! Wonderful companion pieces and an affirmation of the broader concept and results: https://t.co/jn6wAw9vYF
Absolutely excited to share the lab’s first paper in @nature, investigating the landscape and function of multiple driver mutations (MMs) within individual oncogenes. @yukisaito_1990 @JunjiKoya #CancerGenomics #NGS #Genomics #Pancancer #Oncogene
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Deeply grateful in these times for the wonderful support and collaboration of @ScaltritiLab @LoweLabMSKCC and a faithful partnership with the brilliant @EdReznik throughout.
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Ultimately, mutant cancer genes must be considered, both biologically and clinically, in their allelic context, with implications for our understanding of cancer gene function, malignant phenotypes, and therapy.
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