Serena Nik-Zainal
@SerenaNikZainal
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Professor of Genomic Medicine | #NHS | needs regular snacks | delivers an effective roundhouse kick | Though she be but little, she is fierce
Cambridge, England
Joined October 2015
It’s cheaper to fly to Belfast than to take a train from Cambridge to London… what…
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SO HAPPY to get to the weekend and go CELEBRATE LIFE with my girlies for the hell of it! 🥳
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Mitochondrial origins of the pressure to sleep . What an interesting paper! .Provocative but deserving of Nature. (and not some of other shit I’ve read recently 😂… non- controlled politics-driven hyped up drivel…)
nature.com
Nature - Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.
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Signposting the upcoming Early Detection of Cancer Conference, October 21-23, 2025, Portland, Oregon. Make sure you get your tickets now! Who is gonna join me for science (and a laugh) in Oregon? 🥳.
earlydetectionresearch.com
The Early Detection of Cancer Conference brings together experts in early detection from multiple disciplines to share ground breaking research and progress in the field.
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Shout out to Douglas Anderson of #ClubVita on his mahoosive endeavour #RunBritannia raising funds for @CR_UK. Running the equivalent of 37 marathons back-to-back from Lands End to John O’Groats! Extraordinary!🤯. Please support his amazing cause!👇
2025tcslondonmarathon.enthuse.com
Fundraising update: 13 August All done! Jill and I have been really touched, now receiving almost 300 donations: they really helped to motivate us to keep going through the pain. One of our fellow run
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RT @nussenza: Cytarabine has been the mainstay for AML treatment. This chemotherapy can lead to problems with movement and balance. Here we….
nature.com
Nature - Certain antimetabolites used to treat cancer are more neurotoxic than others, and it is now shown that this is due to their greater tendency to generate DNA double-stranded breaks, whereas...
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Too many emails. Too much admin. Just. Hit. Delete.
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RT @WTKLAB: Check out our latest paper out @embojournal. 10 years in the making - congratulations to all members the lab that contributed o….
embopress.org
imageimageTumour-specific protein–protein interactions remain underexplored in the development of targeted cancer therapies. This study uses multi-omics and biophysical analyses to identify chromatin...
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So how many people have hidden Easter eggs in the garden ??.🍫🐣🐣. (My babies are now 20 and 17…).🙈🫢😂.
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Tunisia 🇹🇳 is fabulous!. A cultural & historic melting pot, captured by this inscription in Arabic & French at the Cathedral of St Louis, Byrsa Hill, the seat of Carthage. Indeed, perhaps in life, we would each find every day a new marvel that we had not noticed before. 💖
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Secret to peak health and longevity. They lost me at tip number 1: . “Julie gets up between 4 and 5am…”.
She’s reinventing the science of aging. Meet Julie Clark: the 56-year-old whose biological age clocks in at 36. She’s outpacing Bryan Johnson, the $2M-a-year biohacker, on a mere $4/day. Here's her simple anti-aging routine for peak health and lasting longevity: 🧵
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Advert alert ‼️ . Bioinformatics PhD student coming to the end of her training. Seeking a GREAT industry role in UK. Keen to broaden horizons. Super smart, great thinker, completely lovely. Distinction masters .1st class degree, deans list. DM/email me for her CV. 😉.
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@GeneChChKoh @ScottNanda @xueqing_zou @biopeps_017 @GenomicsEngland @HartwigMedical @CR_UK @CancerGrand @NIHRresearch @BCRFcure @CambridgeBRC And to reinforce, this superb effort was ably led by @GeneChChKoh who is a Sir Jeffrey Cheah Early Career Research Fellow. generously supported by the @JeffreyCheahFDN .Thank you for your support 🙏!!.
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@GeneChChKoh @ScottNanda @xueqing_zou @biopeps_017 Finally, thank you to patients that share samples/data, colleagues, collaborators @GenomicsEngland @HartwigMedical . And our generous funders 🥹.@CR_UK @CancerGrand .@NIHRresearch @BCRFcure #JosefSteiner #GrayFoundation @CambridgeBRC .🙏💕.that enable us to do our research! ./end.
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Conclusion: the classification matters! . This would could not be achieved without the leadership, grit and determination of @GeneChChKoh Supported by @ScottNanda @xueqing_zou @biopeps_017 .& many more . 12/n.
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BTW TMB which is used to identify MMRd cases for ICI, has poor specificity, often calling samples with other signatures as TMB high. Consistent in several cohorts. Using signatures gives much greater specificity for clinical classification. 11/n
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We created a multinomial classifier PRRDetect that can call MMRD, poly dysfunction, combined, or neither. Performance was better than any other classifier or similar ilk. 10/n
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And we see a bucketload of MMRD and polymerase dysfunction signatures and combined ones too. Not just one signature (as in COSMIC ID7). 9/n.
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We do highlight an APOBEC indel signature! . Mechanism proposed therein. 8/n
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