
Sridevi Rajeeve, MD
@sridevirajeeve
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⚕️Asst. Attending Myeloma & Cell Therapy @MSKCancerCenter via @MountSinaiNYC @TischCancer 🇮🇳➡️🇺🇸 Interests: #MMsm #CART #cellulartherapy
New York, NY
Joined August 2009
Amazing evening receiving the @ASCO @ConquerCancerFd Young Investigator Award (YIA) 2022. Thankful to my stellar mentor Dr. Samir Parekh at @IcahnMountSinai & @TischCancer @SinaiHemeOnc for the support! #ASCO22 📸3: friends, old and new @drsomedeb 📸4: proud hubby @suchithnair
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Excited to share new study out today on @JCO_ASCO where we leveraged #WGS to reclassify MGUS and SMM and define the concept of "malignant transformation" @MSKCancerCenter @LaStatale @MDAndersonNews @MoffittNews @SylvesterCancer @nyulangone @sangerinstitute @MayoClinic #mmsm 1/14
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#Myeloma Paper of the Day: AURIGA subgroup analysis finds dara/len maint in NDMM -> higher MRD (10-5) conversion @ 12 mos in original high-risk (31.8 vs 6.7%), revised (43.8 vs 13.3%) & modified IMS 2024 (41.2 vs 0%) & ultra-high-risk (54.5 vs 0%): https://t.co/0AEbUmNJZ2.
#mmsm
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Following an exciting #IMS25, looking forward to synthesizing data across all #PlasmaCellDisorders for the 2nd Annual Kyle-Barlogie Symposium by @MayoClinic & @MSKCancerCenter. 📍 Minneapolis 📅October 10-11, 2025! Link: https://t.co/zDvs1a8A8C 📢Trainees: Complimentary reg!
I’ll be speaking at this meeting next week. Also speaking are @szusmani @FrancescoMaura4 @UrviShahMD @sridevirajeeve @LesokhinMD and more from @MSKCancerCenter And many of my colleagues from @MayoClinic including @MorieGertz @ADispenzieri @myelomaMD @JoselleCookMD
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#IMS25 Kudos to @andrew02114 for presenting Alliance trial on the big stage at @Myeloma_Society plenary! 👏 Len 15mg (not 25mg) in this older ASCT-ineligible patient population. Addressing mismatch between trials & RW practice by implementing the latter into the former!
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#IMS25 Oral abstract session: results from the TANDEMM trial at @MSKCancerCenter by Dr. Sham Mailankody, presented by @szusmani. In heavily preTx RRMM, co-infusion of BCMA+GPRC5D CART as a dual agent targeting strategy was feasible, tolerable and efficacious. @MSK_DeptOfMed
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#IMS25 ALC spikes post CART may portend DNTs (ALC >2.4) and Parkinsonism (ALC >3.9) but have no impact on efficacy. Key data that may help harmonize post CART ALC measurements and time points, including advising on interventions to mitigate and prevent DNTs! (⏩CITADEL trial)
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🎵 TACI’s back, alright! Excellent #IMS25 by Puliafito @NoopurRajeMD @MJFzeta et al … using APRIL as CAR (binds both BCMA & cousin TACI) worked well here even in prior BCMA CAR-T failure. Prior @DrRakeshPopat study of APRIL CAR had low ORR - looking forward to learning more!
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#IMS25 Phase 1 data from the TriPRIL CAR-T (dual targeting BCMA-TACI using natural ligand trimeric APRIL) from MGH showing 80% ORR in a real-world like pt pop (preTx, prior BCMA✅), no new safety signals and (so far) no NINS. Good use case of retargeting BCMA (after 6m break)!
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#IMS25 Important summary slide on CAR+ T-cell lymphomas from the Immunotherapy session by @BenjaminPuliaf1. Comprehensive workup is needed for all post CART toxicities, especially unusual signs and symptoms, given the heterogeniety of T-cell lymphoma manifestations.
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#IMS25 Late breaking abstract presented by @CohenAd_MMdoc of STEM study - fixed duration cevostamab consolidation following BCMA CAR-T: tolerable, and with 1y CR rate >90%. Long term f/u data will advise durability of this deep response but can consider, esp in #HRMM!
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Revised Definition of Free Light Chains in Serum and Light Chain Monoclonal Gammopathy of Undetermined Significance: Results of the iStopMM Study [Dec 10, 2023] Long et al. #ASH23 Abst 535 https://t.co/PZKnY2Fq3v
#mmsm #geriheme
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New Definition of Light Chain Monoclonal Gammopathy of Undetermined Significance [MGUS] [May 29, 2025] Long et al. @sykristinsson @JAMAOnc
https://t.co/TDE6QUWfoP
#mmsm #geriheme
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Guidelines for the testing and reporting of cytogenetic results for risk stratification of multiple myeloma: a report of the Cancer Genomics Consortium Plasma Cell Neoplasm Working Group [Jun 18, 2025] Lu et al. @lbaughn @BloodCancerJnl
https://t.co/lCE7EDugND
#mmsm #hemepath
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Happy to share our new work out today on @BloodPortfolio #Blood where we report CD38 loss as recurrent mechanisms of resistance to anti-CD38 antibody in multiple myeloma. Great collaboration between @MSKCancerCenter @MSK_DeptOfMed @UCalgary @HDMyeloma @MayoClinic #mmsm #wgs
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We call for a paradigm shift in development of immunotherapy drugs, especially bispecifics. @LeukemiaJnl These drugs have therapeutic effects that last a long time. We need to reduce frequency and switch to limited duration treatment to avoid toxicity. https://t.co/w9Cj9Kqx8U
nature.com
Leukemia - Time for a paradigm shift in immunotherapy-based BCMA/CD3 bispecific drug development in multiple myeloma
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Early results in patients who had failed prior CAR T: → 81% overall response → 52% complete remission at 3 months → 3-day manufacturing turnaround This research from @carlhjune and team represents the first IL-18–secreting CAR T tested in blood cancer — and it may reshape
For patients with lymphoma that relapses after CAR T, clinical options become vanishingly few. Now, a new study in @NEJM led by @carlhjune, Director of the PICI Center @PennMedicine, offers a new approach: huCART19-IL18 –– an IL-18–secreting, “armored” CAR T-cell.
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Dr. @RahulBanerjeeMD from @fredhutch talks on #Cevostamab: A “third-party candidate” in myeloma? ✅ FcRH5 target, maintained post-BCMA exposure ✅ Manageable safety, fewer infections vs. BCMA bsAbs ✅ No GPRC5D toxicities ⏳ Needs better efficacy/durability! #DAVAWhistler
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Looking forward to the inaugural #iwGPRC5D International Workshop on GPRC5D-Targeted Myeloma Therapies on March 22 in NYC! https://t.co/WcXWhyk1sW Excited to learn & share our collective knowledge on the next frontier beyond BCMA. @szusmani @ShamMailankody @NoopurRajeMD ...
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So excited!! Welcome @UrviShahMD to @fredhutch Grand Rounds. I’m glad you joined by Zoom since shockingly it is raining today in Seattle for the first time in 2 weeks :) Cc @MSKCancerCenter @szusmani @sridevirajeeve @GunjanLShah @MScordoMD #MMsm
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