Robert Z. Orlowski
@Myeloma_Doc
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Deputy Chair of Lymphoma/Myeloma, Vice Chair MM Research @ MD Anderson; Translational researcher who hates myeloma. Tweets are my own. Retweets ≠ endorsements.
Houston, Texas
Joined September 2010
Faculty positions available for #myeloma clinician scientists. Join our @MDAndersonNews #Myeloma Team!.Please RT!
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RT @michaelwangmd: In MCL, pirtobrutinib creates drug-tolerant persister cells via a nongenetic metabolic switch; targeting these cells cou….
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RT @Amyloidosis_ARC: Over the past decade ARC has driven bold science, sparked critical breakthroughs, and brought new hope to people livin….
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RT @BLLPHD: Optimal Pairing of Binder and Costimulatory Domains Improves Dual CAR T Cell Efficacy - Targeting both CD19 and CD22 with optim….
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RT @SWOG: #ClinicalTrial S2417CD asks if a web-based intervention can increase the rate of guideline-recommended surveillance in #CRC survi….
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RT @SWOG: Up to 40% of patients w stage 2 or 3 #colorectal cancer will have a recurrence. If found early, these can often be cured, so surv….
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According to a review article on this topic (, short chain fatty acids may improve bioavailability of oral & parenteral formulations by up to 16-fold. That's a far cry from the needed 400,000-fold increase as per my recent thread. I remain unconvinced.
pubmed.ncbi.nlm.nih.gov
Many drugs have decreased therapeutic activity due to issues with absorption, distribution, metabolism and excretion. The co-formulation or covalent attachment of drugs with fatty acids has demonst...
@Myeloma_Doc It's mentioned! This is why I have her on the bacillus family probiotics, from Microbiome labs. Robert, the bacillus family produce short chain fatty acids. The (SCFAs) makes the "Berberine HCL" more bioavailable. I got her on some methylated B- vitamins for the altered DNA met.
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RT @SWOG: Our #TranslationalMedicine Link of the Week, chosen by @SWOG's @recnac1 & Jimmy Rae, PhD:.Oncogenic Gene Fusions in Cancer: From….
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4/4 … a recent study of berberine's effect on misfolded protein oligomers ( used 30 micromolar (or a >400,000-fold higher level). Thus, you would have to convince me that your "Pennington" protocol (as you call it) can overcome this issue.
pubmed.ncbi.nlm.nih.gov
Numerous neurodegenerative disorders, including Alzheimer's and Parkinson's diseases, are associated with the misfolding and aggregation of proteins. In this study, we investigate the protective role...
@Myeloma_Doc #3- Myeloma Doc, do you want to get into the causations of all the cytokines,chemokines and signaling pathways that are involved with Myelodysplastic Syndrome (MSD)?. Robert, what supports them dysfunctional lysosomes?. Sir, the "Pennington" protocol is outstanding.
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3/4 … delivered to the tumor or the microenviornmental cells (reviewed in . With berberine, for example, one “study reported that the Cmax of berberine in 10 healthy individuals given 500 mg berberine orally was extremely low, at 0.07 nM.” In contrast, ….
pubmed.ncbi.nlm.nih.gov
Traditional Chinese medicine plays a significant role in the treatment of various diseases and has attracted increasing attention for clinical applications. Vascular diseases affecting vasculature in...
@Myeloma_Doc #3- Myeloma Doc, do you want to get into the causations of all the cytokines,chemokines and signaling pathways that are involved with Myelodysplastic Syndrome (MSD)?. Robert, what supports them dysfunctional lysosomes?. Sir, the "Pennington" protocol is outstanding.
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2/4 … do not reflect what can be achieved from oral dosing in humans. There is extensive first pass hepatic metabolism for many of these agents after oral dosing which results in only a small fraction of the parent compound making its way to the blood from where it may be ….
@Myeloma_Doc #3- Myeloma Doc, do you want to get into the causations of all the cytokines,chemokines and signaling pathways that are involved with Myelodysplastic Syndrome (MSD)?. Robert, what supports them dysfunctional lysosomes?. Sir, the "Pennington" protocol is outstanding.
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1/4 @pennington37258 I know u are a big fan of berberine and I agree it is an interesting compound and deserves study, as do many other natural products. My concern with most of the literature in this space is that the mechanistic studies use high doses in in vitro models that ….
@Myeloma_Doc #3- Myeloma Doc, do you want to get into the causations of all the cytokines,chemokines and signaling pathways that are involved with Myelodysplastic Syndrome (MSD)?. Robert, what supports them dysfunctional lysosomes?. Sir, the "Pennington" protocol is outstanding.
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#Myeloma Paper of the Day: Mayo Clinic Consensus Statement on heart transplantation for #amyloidosis (including AL/light chain) offers comprehensive approach to heart failure, including a pre-transplant assessment & post-transplant management: #mmsm
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RT @GevTamamyan: The influencers of #Oncology on X for the last week according to SymplurRank. And @OncoDaily, as usual, is on the top :)….
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