Heidelberg Myeloma
@HDMyeloma
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Heidelberg Myeloma Center @RaabMarc Niels Weinhold @EliasKarlMai @uniklinik_HD @DKFZ #mmsm #myeloma
Heidelberg, Germany
Joined April 2023
#OnlineFirst Acquired and Selected: Tracking Antigen Escape during T Cell–Redirecting Therapies in #MultipleMyeloma
https://t.co/4Nn2ObH0Qm
#immunotherapy @RaabMarc
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It's time for the #FiveUnder5 🕒. Check out the top #oncology videos of the week 📷: https://t.co/0t7s5WOoYm
@HOGONC @DanaFarber @harvardmed @stolaney1 @efratdotan @LGHealth @ovanoekelen @IcahnMountSinai @RaabMarc @HDMyeloma #bcsm #pancsm #mmsm #medtwitter
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We are happy to collaborate with @HDMyeloma for Germany Patient & Family Seminar having the opportunity to listen Dr. Charlotte Pawlyn as our guest speaker. #knowmyeloma #myeloma #multiplemyeloma
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1st results of the #GMMGHD7 imaging substudy presented at #IMS2025 ➡️ lower WB-MRI (MY-RADS) scores correlate with MRD negativity after induction in #mmsm Congrats to @MHajiyianni on receiving the Young Investigator Award for these great work! 👏
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#IMS25 with @EliasKarlMai, the man who will some day be able to tell the world definitely whether CD38 + R outperforms R maintenance… we both may have more gray hairs by the time the study reads out!
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#IMS25 MajesTEC_5: Tec+DaraRV for TE NDMM: N=50, 100% MRD neg by NGS 10-6 after C6, all pts collected stem cells G3 infection 33%, hypogamma 90% MRD neg much higher than SOC DRVd Id this Rx for ‘Time limited therapy’,? Role of ASCT with such high MRD neg rates
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These are some exceptional MRD neg rates allowing us time limited therapy and aim at #curemyeloma
#IMS25 In my mind, this will be the slayer of ASCT more than any other #MMsm regimen... Excellent Tec-DVR & Tec-DR data [1x weekly Velcade & lots of IVIG 👏] in NDMM from MajesTEC-5 @RaabMarc 100% ORR, 100% MRD neg across the board. This is what we hope for with induction!
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#IMS25 room 701 is going to be amazing! Learning from @HangQuach1 @RaabMarc @HiraSMian and many other oral presenters, moderated by #rafatabanour and @mbeksac56
The first #IMS25 abstract sessions start at 11:00 AM! Choose your session: 📍 Room 701 → Abstract Session 1 📍 Room 718 → Abstract Session 2
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Researchers interrogated 580 whole-genome sequence samples from patients with large B cell #lymphoma, multiple myeloma, and myeloid neoplasms. @HDMyeloma They identified the ID8 mutational signature only in relapsed disease. 🧬 https://t.co/ANVlSGwJog | @BCD_AACR
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🔥 CAR-T in Myeloma: Don’t Burn the Bridge 🔥 🧪 Frenking et al. (Blood Adv 2025;9:4151-66, n=158) • 🚫 Intensive alkylator bridging → longer cytopenias (ANC 63d vs 21d) • ⚠️ 50% ↑ severe infections • 📉 Worse PFS & OS vs lower-intensity / no alkylator BT 📖 Take-home:
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Excited to share our new paper, out today on @NatureGenet where we use 421 #WGS to reconstruct the evolutionary history of multiple myeloma #mmsm (🔥🔥). Great collaboration with @HDMyeloma @SylvesterCancer @MayoClinic @MSKCancerCenter @MSK_DeptOfMed .
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When the silence speaks: T-cell dysfunction in myeloma [Jun 26, 2025] @mircoscopy & @RaabMarc @BloodPortfolio
https://t.co/NUpzPYSkZ4
#mmsm #ImmunoOnc #LymphoidNeoplasia
ashpublications.org
In this issue of Blood, Shasha et al report that CD8+ T cells in newly diagnosed multiple myeloma (NDMM) do not exhibit transcriptional, phenotypic, or fun
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🚨NEWS 🚨 The CHMP recommends EC approval of isatuximab in combination with VRd for the treatment of transplant-eligible patients with newly diagnosed #MultipleMyeloma based on results from the phase III GMMG-HD7 trial. Read more: https://t.co/Rc4jxBUIj5
#myeloma #MedEd
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Excited to share our work investigating the mutagenic impact of radiotherapy in hematological cancers out today in @BCD_AACR!! 🎉 Another study born from amazing collaborations across @MoffittNews @HDMyeloma @univmiami @MSKCancerCenter @MSK_DeptOfMed 💪 #lysm #wgs #RT #mmsm
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@NBahlis @BrunoPaiva_UNAV @TCupedo @haas_lab @marc_a_baertsch @RascheLeo @DanaFarber @Leif_Bergsagel @MarkBustoros See you all in 2027 for the 11th Heidelberg Myeloma Workshop
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@NBahlis @BrunoPaiva_UNAV @TCupedo @haas_lab @marc_a_baertsch @RascheLeo Novel targets, molecules and strategies - from CRBN, XPO1, Bcl-2 to NSD2 and NK cells Paul Richardson @DanaFarber Leif Bergsagel @Leif_Bergsagel 🎂 Mark Bustoros @MarkBustoros
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