Soobeom Lee
@soobeomlee
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Research Scientist @NYGCtech | former member at Aifantis lab @nyulangone and Bonneau lab | Single cell & spatial genomics and epigenomics
Manhattan, NY
Joined May 2020
RT @AlexandrePCheng: Highly accurate sequencing OR high throughput? We refuse to choose. Introducing paired plus-minus sequencing (ppmSeq)….
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RT @landau_lab: 🧨Exciting new pre-print! Introducing ppmSeq - cost effective, scalable dual-strand 🧬 sequencing. Scalability & ultra-low er….
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RT @Cancer_dynamics: The IICD SRP is wrapping up soon! Yesterday, our interns presented their research at the Columbia CUPP Symposium. Huge….
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RT @drklly: I'm excited to share work on a research direction my team has been advancing: connecting machine learning derived genetic varia….
biorxiv.org
Genome-wide association studies (GWAS) have identified thousands of trait-associated loci. Prioritizing causal variants within these loci is critical for characterizing trait biology. Statistical...
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RT @ewang2323: 🧵1/.Thrilled to share our lab’s first paper, just out in @BloodCancerDisc led by the talented @Cuijuan3 .We uncovered an iso….
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RT @CKBrierley: 🚨🚨Paper out! 🚨🚨.Delighted to share our work, now published in @NatureGenet 🧬! We identified a targ….
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RT @PapaemmanuilLab: Phenotyping recurrent genomic architectures. Led by @MariaSirenko @soobeomlee & Z. Sun, our study @CellStemCell shows….
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RT @AlejoFraticelli: Absolutely thrilled to share with you the final version of EPIclone, out now (open access) in @Nature. This has been….
nature.com
Nature - The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell...
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Please check out the full tweetorial!.
Delighted to share our study out in @CellStemCell today from the dream team @PapaemmanuilLab @iannisaifantis1 @AkEisfeld @landau_lab! . We profiled IDH-mutated AML patients to define how IDH and co-mutations shape the disease at baseline and responses to IDH-inhibitors. 🧵👇
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RT @sanamloghavi: Congratulations to this powerhouse of a team!!! leukemia science at its best!!!.#hemepath #AMLsm aficionados please dig….
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I am deeply grateful to our amazing mentors, @iannisaifantis1 , @PapaemmanuilLab , @AkEisfeld , @landau_lab — who taught me how to collaborate openly and peruse science that ultimately helps patients! This is absolutely more than one paper to me!.
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Super excited that our paper is finally out! A truly wonderful team effort with Maria and Zhengxi, and multi-institutional collaboration to study the full life span of IDH-mutant cells — from CH to AML diagnosis, remission under chemo and targeted therapies, and relapse.
Excited to share with all our latest work on the use of single cell tools in following IDH mutant AML patients during their treatment! Out today @CellStemCell !! An amazing collaboration with @AkEisfeld & @PapaemmanuilLab & @landau_lab !!! Driven by the impressive @MariaSirenko
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RT @iannisaifantis1: Excited to share with all our latest work on the use of single cell tools in following IDH mutant AML patients during….
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RT @FraticelliLab: Finally out in Nature our collaboration with the Velten Lab 🥰 Enjoy the reading! .
nature.com
Nature - The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell...
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RT @xu_zxu: I'm thrilled to share our new #bioRxiv preprint from @junyue_cao lab at @RockefellerUniv! We present PerturbFate, a high-th….
biorxiv.org
High-throughput genomic studies have uncovered associations between diverse genetic alterations and disease phenotypes; however, elucidating how perturbations in functionally disparate genes give...
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RT @PapaemmanuilLab: It has been unclear why cancer patients with CH have worse outcomes. Our work published @NEJM uncovers that Tumor in….
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RT @TrowbridgeLab: New paper from my lab! Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal….
nature.com
Nature - Metformin could reduce people’s risk of certain age-associated blood cancers, but more work is needed to identify who is likely to benefit.
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RT @drklly: Regulatory sequence ML has been widely applied to predict substitution SNP effects (to promising results!), but most teams have….
biorxiv.org
Determining genetic variant effects on molecular phenotypes like gene expression is a task of paramount importance to medical genetics. DNA convolutional neural networks (CNNs) attain state-of-the-...
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RT @landau_lab: Excited to share our exploration @naturemethods into new horizons opening up in the era of low cost sequencing!. 🔥 Deeper s….
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