Elli Papaemmanuil, PhD
@PapaemmanuilLab
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Computational Oncology. Explores 🧬 tech, algorithms & data to improve diagnosis & treatment decisions in oncology. Opinions my own. Disclosures: https://t.co/UK0HUZr28Y
Memorial Sloan Kettering, USA
Joined April 2015
You can now access the IPSS-M through web, android and apple app store! Web: https://t.co/qg6zMV9fFv iOS: https://t.co/8HIpS3v1sz Android:
play.google.com
The IPSS-M is the newest MDS prognosis calculator which considers gene mutations
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Proud science mum moment! Many congratulations to the superstar @Elsa2Bernard for being awarded the ERC starter grant! ⭐️ https://t.co/htTI70xZA3
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This is not the usual phylogenetic tree of somatic mutations showing what clonal expansions are present and when they arose in a tissue. It additionally shows which cells within the tissue are affected and how the mutations change those cells. Congrats @landau_lab! Lovely work!
Big, beautiful trees!! SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life. https://t.co/pciw5yME0x
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BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 It started from my frustration with the depressing effect that the current publishing system has
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Today we're releasing a preprint describing the incidence, physiology + molecular features of cachexia in 60,000 MSK patients. A herculean effort by Venise Jan Castillon, Amy Xie, and our whole lab.
medrxiv.org
Cancer cachexia is a wasting syndrome with outsized impact on morbidity and mortality. Neither the etiology of cachexia, nor its consequences on patient physiology and outcomes, are well-understood....
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How can this be "Americas most convenient bank" with no branches outside of the east coast and no online solutions?
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🚨 If you bank with @TDBank_US and happen to be outside the East Coast, you’re locked out of routine banking: no wires, no cashier’s checks, no withdrawal increases. You literally can’t access your own $ without flying back to an EC branch. @CFPB_Watch — okay with this?
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#ClinicalTrial MM1OA-EA02, led by @jaltmanmd of @LurieCancer, aims to improve results for older adults with #AcuteMyeloidLeukemia (#AML). Learn more: https://t.co/8vVaF19FDX
#BloodCancer #leukemia
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Dr @sanamloghavi kicking off #2025PPLC on unifying disease classification in myeloid neoplasms + exemplifying the role of population based studies on criteria definition incl VAF, allelic state & patterns of co- mutations with data from our recent study https://t.co/G52phDipZx 🙌
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Excited to share our latest study, led by @CLachowiez & @sanamloghavi on the relevance of data informed metrics in setting guidelines for disease classification in myeloid neoplasms.
Happy to share our newest work out today in BCD evaluating disease classification and prognosis in the “world of myeloid malignancies”! Wonderful collaboration with @sanamloghavi @PapaemmanuilLab @Elsa2Bernard and colleagues.
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🚨🚨Paper out! 🚨🚨 Delighted to share our work, now published in @NatureGenet 🧬! https://t.co/7KJpQBsLWq We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n 🧵👇
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On the eve of #ASCO25, it's #AcuteMyeloidLeukemia Thursday. Here are Top Posts of the Week! 🎉🎉🎉 1/ @PapaemmanuilLab on how patterns of co-mutations shape lineage composition + drive diverse cellular programs in AML: https://t.co/GOVk72UnSO
Phenotyping recurrent genomic architectures. Led by @MariaSirenko @soobeomlee & Z. Sun, our study @CellStemCell shows how patterns of co-mutations shape lineage composition + drive diverse cellular programs in AML. Awesome collaboration with @landau_lab @iannisaifantis1++🧵⬇️
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Phenotyping recurrent genomic architectures. Led by @MariaSirenko @soobeomlee & Z. Sun, our study @CellStemCell shows how patterns of co-mutations shape lineage composition + drive diverse cellular programs in AML. Awesome collaboration with @landau_lab @iannisaifantis1++🧵⬇️
Excited to share with all our latest work on the use of single cell tools in following IDH mutant AML patients during their treatment! Out today @CellStemCell !! An amazing collaboration with @AkEisfeld & @PapaemmanuilLab & @landau_lab !!! Driven by the impressive @MariaSirenko
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Congratulations to @MSKCancerCenter MSK-IMPACT team and @OncoKB for receiving the #AACR25 TEAM Science Award! The impact of this team, assay & data to our understanding of cancer biology is unprecedented.
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Excited to share our paper out today in @CellPressNews discovering RNA mis-splicing derived neoantigens & their cognate T cell receptors (TCRs) as well as characterization of endogenous neoantigen T cells in leukemia patients. https://t.co/hVucfdL0oZ
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Tumor infiltrating clonal hematopoiesis associated with poor outcomes in solid tumors. Wonder if this is how IL1B inhibition seemed to improve survival from cancer in CANTOS…
nejm.org
Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele frequencie...
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It has been unclear why cancer patients with CH have worse outcomes. Our work published @NEJM uncovers that Tumor infiltrating CH (TI-CH) has a direct role in immune remodelling of the TME with implications for tumor progression & treatment response. @MSKCancerCenter @TheCrick
New evidence today @NEJM that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers https://t.co/J8zAskV32l
https://t.co/3uvAc03p8K
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Some trully trainee led science! @Elsa2Bernard @oriol_pich Maria Zagorulya - our work is done here! Read how CH can influence solid tumor progression & treatment response ⬇️ @NEJM with the one & only @CharlesSwanton
@MSKCancerCenter @TheCrick
🚨Thrilled to share our latest work: “Tumor-Infiltrating Clonal Hematopoiesis” @NEJM - we investigated how age-related blood mutations impact cancer when they infiltrate tumors, with @Elsa2Bernard Maria Zagorulya, @PapaemmanuilLab @CharlesSwanton + more https://t.co/PYUKWzSxV2
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Coming back home, New York you are a city like no other 💛
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We are still hoping for a response regarding Aspera account set up & data availability. @EGAarchive would be great if we could work together to resolve this?🙏
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