Sona Tiwari
@sonatiwari1212
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We are thrilled to share our latest work on small molecule lipid droplet inducers in @angew_chem. Congratulations Sai @VechalapuSai and @santhoshd22 for the excellent work. Thanks @Appu and @surithakur86, for the collaboration. @IITKanpur @Director_IITK
https://t.co/WD1RVdNoYP
onlinelibrary.wiley.com
High-fat diets and fatty acids are traditionally used to induce lipid droplet formation in cells and animals. The authors developed a new high-content imaging platform and identified functionally...
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Happy to share our review on the exciting frontier of covalent chemistry aimed at non-cysteine residues — expanding the toolbox for ligand discovery and chemical biology. Congrats to Gibae Kim from my group! https://t.co/ZUPqRzGTkB
@CovalentMod @UTChemistry @UTAustin
pubs.acs.org
Targeting intractable proteins remains a key challenge in drug discovery, as these proteins often lack well-defined binding pockets or possess shallow surfaces not readily addressed by traditional...
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Delightful to see our paper on lysine-selective modifier probes in @CellRepPhysSci made it to the collection of the best chemical biology published so far in CRPS. https://t.co/hsBduLnCmf Congratulations to @sonatiwari1212 and others!
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After seeing multiple posts discussing the flaws of PhD supervisors, finally one representing the other side!
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Covalent targeting of splicing in T cells by Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Ekaterina V. Vinogradova @katenokv and colleagues at @RockefellerUniv @TPCB_NYC @WeillCornell @MSKCancerCenter @scrippsresearch
https://t.co/UBl0FU7h0l
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🎉We are excited to share the preprint link for our work on new small molecules inducers of endogenous lipid droplet accumulation. Congratulations @VechalapuSai @SathyaS46897922 @santhoshd22 and Thanks to @surithakur86 and @Appu_IITK
https://t.co/0hhXknLv2y
biorxiv.org
Lipid droplets (LDs) play a central role in regulating metabolism in stress-induced conditions, including one triggered by nutrient deprivation. Unravelling the protein networks involved in the...
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Online now: Tuning isatoic anhydrides’ lysine ligation chemistry for bioconjugation and drug delivery
cell.com
Lysine-selective covalent modifiers are valuable tools in chemical biology. Tiwari et al. bias the reactivity of isatoic anhydride toward lysine by leveraging the HSAB principle, illustrating its...
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Delighted to share one of the first projects of our lab, @sonatiwari1212 applied the HSAB principle on isatoic anhydrides to drive lysine selective modification in proteins, in @CellRepPhysSci @CellPressNews. Kudos to all, and thanks to @SharathChM! https://t.co/jDhKCnzCsj
cell.com
Lysine-selective covalent modifiers are valuable tools in chemical biology. Tiwari et al. bias the reactivity of isatoic anhydride toward lysine by leveraging the HSAB principle, illustrating its...
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Our recent work in automated, single-cell chemoproteomics to profile protein activity signatures in cancer w/ @SavasTay_UChi ‘s lab and colleagues @UChiChemistry @UChicagoPME @UChicagoMed
https://t.co/rIYzPneZmS
science.org
Mapping protein activity with single-cell chemoproteomics uncovers a metastasis-associated activity signature in breast cancer.
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Selective pH-Responsive Conjugation between a Pair of De Novo Discovered Peptides | Journal of the American Chemical Society @UTokyo_News #Selective #pH #Response #Conjugation #PeptidePair
pubs.acs.org
There is a demand for site-selective peptide/protein conjugation chemistry that is fully reversible in a stimulus-responsive manner. The contemporary methods for site-selective protein modification...
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Call open for the #DBT BioCARe Fellowship for Women Researchers! #BioCARe program supports women researchers who do not have regular positions & with a career break . Apply by 1 Dec 2024. https://t.co/rZWmBTH3FP
https://t.co/Fmm8TVBb8M
https://t.co/Cl4PlPhTWp
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Can we turn the activity of oncogenic kinases against cancer itself? In my postdoc work @Stanford, new in @sciencemagazine, we show exactly that. https://t.co/PZjQxvab7z
#ScienceResearch #InducedProximity @Stanford_ChEMH @StanfordCancer @snsf_ch @StanfordMed
science.org
Kinases are critical regulators of cellular function that are commonly implicated in the mechanisms underlying disease. Most drugs that target kinases are molecules that inhibit their catalytic...
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Proteolysis-targeting drug delivery system (ProDDS): integrating targeted protein degradation concepts into formulation design
pubs.rsc.org
Targeted protein degradation (TPD) has emerged as a revolutionary paradigm in drug discovery and development, offering a promising avenue to tackle challenging therapeutic targets. Unlike traditional...
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For all Macrocycle and Linker afficionados: Check out our perspective recently published in J Med Chem! 📢 The Missing Link(er): A Roadmap to Macrocyclization in Drug Discovery | Journal of Medicinal Chemistry
pubs.acs.org
Macrocycles are one of nature’s preferred choices to generate large but cell-permeable bioactive molecules. Macrocyclization is increasingly prominent in medicinal chemistry beyond natural products,...
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I Bind It That Way - Bioorthogonal Unmasking of Pro-Fluorescent Quinone Methides by Peter Kele, Attila Kormos, and co-workers (Kele_Lab, @ChemBiolHun) #openaccess
chemistry-europe.onlinelibrary.wiley.com
A bioorthogonally driven fluorogenic tagging scheme based on a novel design strategy is presented herein. The concept involving a click-to-release tetrazine unit as the trigger chemically caging a...
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I’m very excited to share (a bit belatedly) this mechanistic story, published last week in @ScienceMagazine:
science.org
Stereochemical editing strategies have recently enabled the transformation of readily accessible substrates into rare and valuable products. Typically, site selectivity is achieved by minimizing...
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Chemoproteomics Identifies State-Dependent and Proteoform-Selective Caspase-2 Inhibitors
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My first first-author paper is out now! Check out the tweetorial by @AChemSynBio. Towards synthesizing new-to-nature biopolymers!
The work by @cpsoni_74 on a Translation-Independent Directed Evolution Strategy to Engineer Aminoacyl-tRNA Synthetases is finally out! @cgem_cci
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Phosphorylation of ACSL4 by mitochondria-located metabolic kinase PCK2 is critical to regulate ferroptosis-associated phospholipid remodeling in tumor repopulating cells that are resistant to chemotherapy and radiotherapy. Read it here https://t.co/NqvucgzeQ6
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Extending my thanks to @Dharma_IITK for giving me an opportunity to explore this beautiful piece of work
Thrilled to announce @VechalapuSai work published in @iScience_CP @CellPress Part 1. Iron complex programs Apoptosis in cancer cells Congratulations and thanks to @Appu_IITK @BioMeDHs for the support. https://t.co/PqSpwfswLc
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