Ku-Lung Hsu
@Hsu_Lab_UVa
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Ku-Lung (Ken) Hsu is an Associate Professor of Chemistry at the University of Texas Austin
Austin, TX
Joined July 2017
RT @Hsu_Lab_UVa: Happy to share our review on the exciting frontier of covalent chemistry aimed at non-cysteine residues — expanding the t….
pubs.acs.org
Targeting intractable proteins remains a key challenge in drug discovery, as these proteins often lack well-defined binding pockets or possess shallow surfaces not readily addressed by traditional...
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Happy to share our review on the exciting frontier of covalent chemistry aimed at non-cysteine residues — expanding the toolbox for ligand discovery and chemical biology. Congrats to Gibae Kim from my group!.@CovalentMod @UTChemistry @UTAustin.
pubs.acs.org
Targeting intractable proteins remains a key challenge in drug discovery, as these proteins often lack well-defined binding pockets or possess shallow surfaces not readily addressed by traditional...
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Human PTGR2 Inactivation Alters Eicosanoid Metabolism and Cytokine Response of Inflammatory Macrophages | ACS Chemical Biology
pubs.acs.org
Prostaglandin reductase 2 (PTGR2) regulates inflammatory lipid signaling through the metabolism of the PGE2 metabolite 15-keto-PGE2. PTGR2 inhibitors have been reported but whether small molecule...
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RT @Hsu_Lab_UVa: Thrilled to share our new covalent AKR1C3 inhibitor targeting a non-catalytic tyrosine (Y24) with proteome-wide selectivit….
pubs.acs.org
Aldo-keto reductase family 1 member C3 (AKR1C3) is a member of the AKR superfamily of enzymes that metabolize androgen, estrogen, and prostaglandin substrates that drive proliferation in hormone-de...
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RT @mads_chem: Exciting new work from @Hsu_Lab_UVa developing #covalent inhibtors that target tyrosine #SuTEx #ABPP #Chembiol.
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Thrilled to share our new covalent AKR1C3 inhibitor targeting a non-catalytic tyrosine (Y24) with proteome-wide selectivity! An enabling tool for probing metabolism in hormone-driven cancers. Big congrats to Justin Grams from my team!.
pubs.acs.org
Aldo-keto reductase family 1 member C3 (AKR1C3) is a member of the AKR superfamily of enzymes that metabolize androgen, estrogen, and prostaglandin substrates that drive proliferation in hormone-de...
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Finishing the year with a review on applications of intact and native protein analysis for chemical proteomics. Congrats to postdoctoral fellow Alexis Edwards from my group @UTChemistry @TexasScience @UTAustin .
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Congrats to my team @UTChemistry for developing sulfonyl-azoles as tyrosine-reactive electrophiles. Thank you to @WelchFoundation for the support.
chemistry-europe.onlinelibrary.wiley.com
Herein, we developed a series of sulfonyl-azole (SufAz) probes to investigate chemical reactivity and applications for chemical proteomics. Our studies identified aryl sulfonyl imidazoles as a...
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RT @hargrovelab: After 11 great yrs @DukeU, the Hargrove Lab is starting a new chapter @chemuoft & @UTM ! We are deeply grateful for everyo….
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RT @glyconet_nce: Upcoming webinar with GlycoNet investigator Dr. Lara Mahal! @glycocode . #glycotime #glycomics.
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RT @KleinerLabRNA: I'm very excited to share the news of my promotion. Much of the credit goes to the trainees that drove the research forw….
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RT @_chrisgparker_: A big congratulations to Dr. Homan @RickHoman4!!! Fabulous job! Rick is our 2 of 2 first Ph.D’s! Thank you @Michael_A_….
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RT @UTChemistry: We're honored to host Yi Tang of @uclachem, this year's Vista Chemical Company Regents Endowed Memorial Lectureship in Org….
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RT @DanNomura: Had tons of fun hearing good science at the 2024 Drug Discovery Chemistry meeting and also hanging out with friends Nir Lond….
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RT @TheMarkFdn: Apply now for the 2025 Mark Foundation Emerging Leader Award! Grants are awarded to early-career investigators in US and Ca….
themarkfoundation.org
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RT @_chrisgparker_: Integration of DOS with PAL-based chemoproteomics from the Cravatt Lab. Further highlights the power of stereochemicall….
biorxiv.org
Chemical proteomics enables the global assessment of small molecule-protein interactions in native biological systems and has emerged as a versatile approach for ligand discovery. The range of small...
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RT @_chrisgparker_: Excited to share the final version in.@nchembio. Lots more mechanistic insights & characterization, including our inhib….
nature.com
Nature Chemical Biology - Integrated chemoproteomic development of selective small-molecule SLC15A4 inhibitors and their functional characterization establish SLC15A4 as a druggable target for...
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