Covalent Modifiers
@CovalentMod
Followers
5K
Following
66
Media
424
Statuses
842
A feed for the blog https://t.co/pXYAKACULR. Discusses the covalent modification of proteins. Available on bsky and mass std don
Ottawa, Ontario
Joined April 2017
Zongertinib (BI 1810631), an Irreversible HER2 TKI, Spares EGFR Signaling and Improves Therapeutic Response in Preclinical Models and Patients with HER2-Driven Cancers
0
0
6
Design, synthesis and biological evaluation of the activity-based probes for FGFR covalent inhibitor
0
2
6
Discovery of a Novel Serine-Targeting Covalent Inhibitor against HCES2A for Treating Drug-induced Diarrhea and Ulcerative Colitis
0
0
6
Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30
0
0
2
Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine
0
0
1
Discovery of Carbodiimide Warheads to Selectively and Covalently Target Aspartic Acid in KRASG12D
0
1
7
Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads
0
0
4
Glecirasib, a potent and selective covalent KRAS G12C inhibitor exhibiting synergism 2 with cetuximab or SHP2 inhibitor JAB-3312
0
3
6
RT @HartungIngo: Clinical update for zoldonrasib - Ras(on)G12D selective covalent inhibitor - dosed at 1200 mg qd po (MTD previously not re….
0
10
0
Discovery and Optimization of a Covalent AKR1C3 Inhibitor
0
0
1
DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders
0
1
4
Proteomic Ligandability Maps of Phosphorus(V) Stereoprobes Identify Covalent TLCD1 Inhibitors
0
0
4
Discovery and Optimization of a Covalent AKR1C3 Inhibitor
0
0
5
Discovery of RNA-Reactive Small Molecules Guides Design of Electrophilic Modules for RNA-Specific Covalent Binders
0
1
2
Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria
0
0
2
Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation
0
0
1
Covalent Modification of Glutamic Acid Inspired by HaloTag Technology
0
0
2
If you'd like to follow Covalent Modifier content on LinkedIn, our "company page" is online
0
2
6
A predictive model for thiol reactivity of N-heteroaryl α-methylene–γ-lactams—a medicinally relevant covalent reactive group
0
1
6
Discovery of Elironrasib (RMC-6291), a Potent and Orally Bioavailable, RAS(ON) G12C-Selective, Covalent Tricomplex Inhibitor for the Treatment of Patients with RAS G12C-Addicted Cancers
0
0
3