Rajender Nallagonda
@rajchemraj
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Senior Scientist at Bristol Myers Squibb
Princeton, New Jersey
Joined May 2014
I'm really excited to see this out now in JACS! Morpholine synthesis from common amino alcohols using an affordable commercial reagent! Let's freaking go!!! https://t.co/sDIIKgdnpC
pubs.acs.org
Morpholines are common heterocycles in pharmaceutical and agricultural products, yet methods to synthesize them from 1,2-amino alcohols are inefficient. We report the simple, high yielding, one or...
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Hey everyone! I am super excited to share that my first corresponding author paper from #BMSChemistry has been published in @ACSCatalysis! Big shoutout to my excellent collaborators and colleagues for their support. Special thanks to @oderinde_m! @bmsnews
https://t.co/vrmN9zPsxn
pubs.acs.org
Decarboxylative cross-coupling methodologies are now widely employed in pharmaceutical drug discovery research, forming the basis of strategic retrosynthetic analysis and radical-based bond disconn...
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Excited to start our Ni adventure with C-F activation! Have a look at our preprint at ChemRxiv - https://t.co/gepnqWJACf. Keep up the great work @Duran_Arr and Roger!
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Very happy to share the latest publication from our group in @J_A_C_S! Many congratulations @rahul_suresh9 and Noam Orbach! Well done đđ Synthesis of Stereodefined Polysubstituted Bicyclo[1.1.0]butanes | Journal of the American Chemical Society
pubs.acs.org
We report a highly diastereoselective synthesis of polysubstituted bicyclobutanes possessing up to three stereodefined quaternary centers and five substituents. Our strategy involves a diastereosel...
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Dinuclear gold-catalyzed divergent dechlorinative radical borylation of gem-dichloroalkanes (@NatureComms): https://t.co/nsVnz4GJuZ.
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As I cannot top this graphical abstract (made by @billthechemist ) just going to repost it. If I are at ACS NOLA come see this awesome line up of speakers.
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Orthogonal sp3-Ge/B Bimetallic Modules: Enantioselective Construction and Enantiospecific #CrossCoupling (Bin Xiao and co-workers) @ustcglobal
onlinelibrary.wiley.com
The acquisition of chiral sp3-Ge reagents for use in stereospecific cross-coupling represents a significant challenge. Herein, unprecedented enantioenriched sp3-Ge/B bimetallic modules were achieved...
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Oxidative Dearomatization of Pyridines | Journal of the American Chemical Society @IGBIllinois @SarlahLab @UofIllinois @TotalSyntheses #Dearomatization #Pyridines
pubs.acs.org
Dearomatization of pyridines is a well-established synthetic approach to access piperidines. Although remarkably powerful, existing dearomatization processes have been limited to the hydrogenation or...
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Selective P450BM3 Hydroxylation of Cyclobutylamine and Bicyclo[1.1.1]pentylamine Derivatives: Underpinning Synthetic Chemistry for Drug Discovery | JACS @UniofOxford @OxfordChemistry @Totalsynth #Hydroxylation #Cyclobutylamine #Biocatalysis #DrugDiscovery
pubs.acs.org
Achieving single-step syntheses of a set of related compounds divergently and selectively from a common starting material affords substantial efficiency gains when compared with preparing those same...
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Iridium-Catalyzed Enantioselective Alkene Hydroalkylation via a Heteroaryl-Directed EnolizationâDecarboxylation Sequence | Journal of the American Chemical Society @Bower_Research @LivUni @TotalSyntheses #Ir #Catalysis #Enantioselective #Hydroalkylation
pubs.acs.org
Upon exposure to a cationic Ir(I)-complex modified with the chiral diphosphine DuanPhos, hydroalkylations of styrenes and α-olefins with diverse heteroaryl tert-butyl acetates occur with complete...
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Check out our most recent publication in @J_A_C_S about selective CâH fluorination of quinolines! Out today and open access! https://t.co/5YPHBGG0et Congrats to all involved!
pubs.acs.org
Direct CâH fluorination is an efficient strategy to construct aromatic CâF bonds, but the cleavage of specific CâH bonds in the presence of other functional groups and the high barrier of CâF bond...
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Our recent work on a deaminative trifluormethylation of aliphatic primary amines using Levin's N-anomeric amide and Grushin's reagent is online in ChemRxiv: Site-specific Deaminative Trifluoromethylation of Aliphatic Primary Amines | ChemRxiv - https://t.co/pPqICtC21g
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đOutstanding work! đ
The LARGEST library of BCPs for Drug Discovery! The reaction requires just light. No catalysts, no additives, no worries. Reaction time: < 30 min. > 300 BCPs on a scale! ChemRxiv: https://t.co/ykoNc7PZJV
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Congrats @Sigman_Lab and awesome to see @rajchemraj 's work explored more!
Congrats to Josh, Avijit, Eli and our wonderful collaborators in the Doyle lab on our efforts to understand Ni(I) oxidative addition mechanisms. @NSF_CSOE
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Congratulations to @Sigman_Lab. So glad to see my work here.
Congrats @Sigman_Lab and awesome to see @rajchemraj 's work explored more!
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Possible to keep the friends and get the gold đ
Are you staying in academia or going to industry after your PhD? #phdvoice #AcademicTwitter #phdlife #phdchat #xp #AcademicChatter
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Our latest work, out now in @JOC_OL, explores the synthesis of dihydropyridine spirocycles via a semi-pinacol-driven dearomatization of pyridines. Great work by Joe and the rest of the team! https://t.co/A1qGWlH0zV
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