AggarwalLab
@AggarwalLab
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Synthetic organic chemistry group focused on the incorporation, homologation and functionalisation of organoboron compounds. Group ran account.
Bristol, England
Joined September 2018
🎉 Huge congratulations to Dr. Malcolm George on successfully defending his PhD thesis! He’s now joining Pharmaron as a Senior Scientist in Process Chemistry. Wishing him every success in this exciting new chapter! 👏
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💍 Looking for a ring? try one with Bpins!. Check out our intramolecular lithiation–borylation route to 1,3-bis-boronic ester carbocycles, now out in @angew_chem. Congrats Chris and team!. 🔗 In collaboration with @merckgroup. #Organoborons @bristolchem.
onlinelibrary.wiley.com
Cyclopentyl and cyclobutyl 1,3-bis-boronic esters have been prepared from benzylic carbamates with excellent regio-, diastereo- and enantioselectivity. The method enables the asymmetric cycloalkanes...
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🌊 From a marine sponge to @angew_chem Novit!. Mycapolyol E: fully synthesized and structurally confirmed via boronic ester homologation. 20 steps (LLS). 12 stereocenters. Congrats @sheenagh_aiken, @DylanRigby6 & team!.🔗 @BristolChem #TotalSynthesis.
onlinelibrary.wiley.com
We report the total synthesis of mycapolyol E in 20 steps (LLS). The ten 1,3-related hydroxy-substituted stereocenters were installed through iterative Pt-catalyzed alkene diboration and reagent-co...
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🌪️🔥🌊🌍 Mastering all four? We did it with alkenes!. Our @Nature paper with @bobbypaton lab reveals a modular boron-mediated strategy solving the long-standing challenge of accessing tetrasubstituted alkenes with full stereo-control. Congrats team!.
nature.com
Nature - A method based on boron-mediated assembly is described for the synthesis of tetrasubstituted alkenes, molecules with four substituents around the central C=C bond, with complete control...
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Radicals, tamed!. Our new @J_A_C_S paper reveals an in situ doublet-state photocatalyst rivaling top photoreductants—enabling borylations & more. Huge congrats to the team! 🎉. #photocatalysis @BristolChem .
pubs.acs.org
Organic free radicals are commonly perceived to be highly reactive species with short lifetimes, yet there are many examples that defy this convention by displaying remarkable stability. Although...
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Congratulations to Hannah on successfully defending her thesis! She is now Dr. Han. Wishing her all the best!
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After his postdoctoral stay @GloriusGroup, we warmly welcome Dr. Jasper Tyler back to the group—this time as our Research Officer. Looking forward to working with you, Jasper!
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This week, we bid farewell to Gianluca, who worked with Hanwen, as he returns to @DellAmico_group at Università di Padova to complete his PhD. Wishing you all the success!
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Bittersweet April as we said goodbye to group members: . Javier returned to UAM to finish his PhD, Dr. Min Siauciulis has a new position in industry, and Dr. Zeshu Wang moved to @Schoenebeck_Lab. Wishing them all every success ahead!
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Huge congrats to Dr. Adam Noble as he kicks off his independent career at Uni Bristol! Your incredible work at the Aggarwal Group has been invaluable. We’re so excited to see where this next chapter takes you!
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RT @NatureSynthesis: Now online & open access:. Article by Malcolm R. P. George, Craig P. Butts, Varinder K. Aggarwal & co-workers @Aggarwa….
nature.com
Nature Synthesis - The structures of 1,5-polyol-containing polyketide-derived natural products are notoriously difficult to determine using spectroscopic techniques due to spectral overlap and...
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Our latest work with the Butt's group, out now on @ChemEurope, enables the facile and quantitative stereochemical assignment of 1,5-diols in natural products. Congrats, Max and Malcolm!. @BristolChem #naturalproducts #stereochem #NMR
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RT @VarinderAggar11: Come and hear the latest from our star-studded speakers at this years BSM. Deadline for registration is 28th March. Pl….
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Congratulations to Dylan on successfully defending his thesis! He is now Dr. Rigby. Wishing him all the best!
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RT @VarinderAggar11: Interesting to discover that organozinc reagents react with inversion of configuration with pi-allyl iridum complexes,….
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Congratulations to Chris, who defended his thesis and is now Dr. Cope, and to Dr. Huaquan Fang for Finishing up your research stay at our group. All the best to both of you!
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Our latest work, out now @J_A_C_S, merged organocatalysis (MBH) w/ 1,2-boronate rearrangement to access enantioenriched, highly substituted indole and indolines. Great work team!🥳. @BristolChem #organocatalysis #boronates #research.
pubs.acs.org
Catalytic asymmetric multicomponent 1,2-boronate rearrangements provide a practical approach for synthesizing highly valuable enantioenriched boronic esters. When applied to alkenyl or heteroaryl...
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Our latest work, in collaboration with @bobbypaton, is out now @angew_chem. We developed a regio- and enantioselective Pt-catalyzed diboration of unactivated alkenes with (pin)B−B(dan), where B(dan) goes to the less hindered carbon. Congrats to team!.
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Out now in @angew_chem, our latest work exploits strain release of ABB and photoredox catalysis for the synthesis of ABH – a Csp3 rich bioisostere of meta-substituted pyridine. Congratulations to the team! #photoredox #research #strainrelease #bioisostere
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