Mykhailiuk Chem 🇺🇦
@MykhailiukChem
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Joined August 2020
This work is now in @J_A_C_S!.
pubs.acs.org
We report a convenient and scalable strategy for the synthesis of 7-azaindolines and 7-azaindoles using O-vinylhydroxylamines as ring-annulation reagents. These fused nitrogen-containing heterocycles...
Strong collaboration with Prof. @kurtilaszlo on the magical conversion of N-oxides into azaindoles!.Great teamwork from Zach, Charlotte, and Olexander!.In @ChemRxiv:
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RT @HariGroupIISc: 🚀Skeletal editing of ketones using [1.1.1]propellane to access functionalized MCB-ketones and spirocyclic scaffolds is o….
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Various POMe₂-building blocks for medchem can be easily accessed from these alkenes:
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Several interesting BCPs for medchem have been prepared this way:
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Very fruitful collaboration with @Malins_Lab and @BaranLabReads on making BCPs without propellane!.In @ChemRxiv: Congrats to Andrii (@Anslob11) and Flynn (@flynn_attard) for the heavy lifting!
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Strong collaboration with Prof. @kurtilaszlo on the magical conversion of N-oxides into azaindoles!.Great teamwork from Zach, Charlotte, and Olexander!.In @ChemRxiv:
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Never in my life would I have thought that this molecule was stable. And yet, it is!
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Now, this study on azetidines is in @JOC_OL! .
pubs.acs.org
Alkyl azetidines have been prepared by photochemical modifications of azetidine-2-carboxylic acids in batch and in flow. The reaction has been realized in milligram, gram, and even multigram quanti...
Terrific collaboration between @EnamineLtd and @pfizer towards alkyl azetidines for medchem!.In @ChemRxiv: Solid teamwork by Oleksandr @Datsenko_Ol, Andrii Baziievskyi, and James @JTBrewsterII!
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The reaction is super-practical and allows the multigram synthesis of azetidines in 1 step!
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Terrific collaboration between @EnamineLtd and @pfizer towards alkyl azetidines for medchem!.In @ChemRxiv: Solid teamwork by Oleksandr @Datsenko_Ol, Andrii Baziievskyi, and James @JTBrewsterII!
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This work on methyl sulfones (with tons of new data) is out in @NatureComms!.
nature.com
Nature Communications - Methyl sulfone is a standard polar substituent used in chemistry and can be found in different agro chemicals or drugs but due to lack of convenient and efficient chemical...
Aromatic methyl sulfones are popular (>30 drugs). Heteroaromatic ones are not (lack of approaches). Not anymore!.A new reagent towards methyl sulfones in one step!.Today in @ChemRxiv
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With this magic chemistry, Ivan (@BarqQ) and Vadym (@vadimscat) have created some cool building blocks for medchem!
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Fantastic work by Honggen Wang (@Honggen_W) on converting alkenes into saturated F2-cycles!.In @angew_chem:
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