Sarlah Lab
@SarlahLab
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Complex Molecules. Enabling Synthesis.
Rice University
Joined April 2019
RT @TotalSynthesis: Stereodivergent #Synthesis of Perhydrobenz[e]indene Terpenoids by Cheng Yang, Christopher J. Huck, @YaroslavBoyko4, Sha….
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Check our synthesis of nimbolide! A streamlined approach enabled by a powerful borylative Heck reaction and a stereochemically interesting alkyl ether formation. Fun fact: two identical twins working on the same molecule. I guess they are trying to keep it in the family😅.
Stereoselective Total Synthesis of Nimbolide | Journal of the American Chemical Society @TotalSynthesis @TotalSyntheses @SarlahLab @RiceChemistry
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Come and join us at GRC Natural Products this summer! We have a fantastic line of speakers from academia and industry. Be a part of the frontiers of science related to the chemistry and biology of bioactive compounds!
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RT @J_A_C_S: Total Syntheses of Scabrolide B, Ineleganolide, and Related Norcembranoids | Journal of the American Chemical Society @SarlahL….
pubs.acs.org
Concise total syntheses of several 5/7/6 norcembranoids, including ineleganolide, scabrolide B, sinuscalide C, and fragilolide A have been achieved through a fragment coupling/ring closure approach....
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Check our hydroamination of arenes! Adding hydride and nitrogen functionality across arenes has never been so easy.
Copper-Catalyzed Dearomative 1,2-Hydroamination (David Sarlah and co-workers) @SarlahLab #OpenAccess
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RT @NatureSynthesis: Now online:. News & Views on the Article by Wen-Xiu Xu, Zhuo Peng, Qing-Xiu Gu, Yao Zhu, Li-Han Zhao, Fucheng Leng & H….
nature.com
Nature Synthesis - Enantioselective hydrogenation is a stalwart reaction in synthetic chemistry. Now, hydrogenation of tetrasubstituted 1,2-dihydronaphthalene esters gives access to more than 30...
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RT @J_A_C_S: Oxidative Dearomatization of Pyridines | Journal of the American Chemical Society .@IGBIllinois @SarlahLab @UofIllinois @Total….
pubs.acs.org
Dearomatization of pyridines is a well-established synthetic approach to access piperidines. Although remarkably powerful, existing dearomatization processes have been limited to the hydrogenation or...
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Great collaboration with #PfizerChemistry, showcasing translation of our dearomatization chemistry to pyridines.
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Congratulations to our former member @Conghui_Tang for an awesome paper!.
Direct C-C Double Bond Cleavage of Alkenes Enabled by Highly Dispersed Cobalt Catalyst and Hydroxylamine (Conghui Tang and co-workers) @Conghui_Tang
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RT @HartungIngo: David Sarlah (@SarlahLab) closing the day at #EFMCASMC23 (with homefield advantage in #Croatia): Larock cyclization strate….
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RT @angierangeles: Day 3 @ACSorganic #GRS2023 Amazing student presentations: Alexander Oanta (Northwestern Univ), David Ryffel (Univ of I….
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It will fit but won't flip! Check out our preliminary collaborative study with @SpiroChemAG and #MerckChemistry, evaluating (very!) rigid Dewar pyridine derivatives as programmable piperidine isosteres.
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RT @J_A_C_S: Total Syntheses of Scabrolide A and Yonarolide @YaroslavBoyko4 @The_Foreign_ @SarlahLab.@ChemistryUIUC @UofIllinois @TotalSyn….
pubs.acs.org
The concise total syntheses of oxidized norcembranoid terpenoids (−)-scabrolide A and (−)-yonarolide have been accomplished in 10 and 11 steps, respectively. The carbocyclic skeleton was efficiently...
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RT @TotalSynthesis: #TotalSyntheses of Scabrolide A and Yonarolide by Roberto Serrano, Yaroslav D. Boyko @YaroslavBoyko4, Lucas W. Hernande….
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RT @PharmToTablePod: It’s here! Check out episode 4 of this season where we talk #TotalSynthesis of Darobactin A, a project in collaboratio….
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RT @NatureSynthesis: Featured in our One year of Nature Synthesis collection. Article by @SarlahLab @pengliu_group….
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RT @J_A_C_S: π-Extended Rubrenes via Dearomative Annulative π-Extension Reaction @NagoyaUniv @Itamilab @SarlahLab @UofIllinois @ChemistryUI….
pubs.acs.org
Among a large variety of organic semiconducting materials, rubrene (5,6,11,12-tetraphenyltetracene) represents one of the most prominent molecular entities mainly because of its unusually high...
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RT @NatProdReports: Our last issue of the year contains this great review from David Sarlah @SarlahLab & co @ChemistryUIUC on dearomative l….
pubs.rsc.org
Covering: 2011 to 2022 The natural world is a prolific source of some of the most interesting, rare, and complex molecules known, harnessing sophisticated biosynthetic machinery evolved over billions...
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Check the story behind our Darobactin #synthesis, hosted by @MatthewHorwitz1. #TotalSynthesis #MerckChemistry.
Today on Synthesis Workshop, David Ryffel (@SarlahLab @ChemistryUIUC) joins us to share his work on the total synthesis of Darobactin A in a brand new Research Spotlight episode!. Episode: @J_A_C_S 2022, 144, 31, 14026.
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Thank you @OPRD_ACS! We truly appreciate and like your manuscripts, and also use them for the training of the next generation of scientists.
sarlahgroup.com
Join @SarlahLab as they regularly highlight different process chemistry articles during their group meetings. For examples see (we like the ones with OPR&D references).
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