GLAD is now >30,000 volunteers. Thanks to all of our participants, supporters, and all the researchers who have helped with recruitment in >200 clinical sites! If you have ever experienced depression or anxiety. @GLADStudy @NIHRBioResource @NIHRMaudsleyBRC

Extraordinary words by Sir John Major on #Brexit at LSE last night: 🧵 🇬🇧 🇪🇺 1. “In an act of collective folly, the United Kingdom voted to lead to European Union across the world, our enemies celebrated and our friends despair.” “We left Europe on a minority vote of 37% of

🏅 Congratulations George Davey Smith, our Scientific Director, on winning @The_MRC Millennium Medal! 🧬 For exceptional contributions to improving human health through world-class medical research 👉 Read more: https://t.co/XP4mKm96NF

Prader-Willi syndrome generally results from loss-of-function of paternally-expressed 15q11-13 while the maternal copy is imprinted, or epigenetically silenced. CRISPR-based epigenomic editing of iPSCs from PWS pts restores expression of the locus from the maternal copy

Despite Ireland being the EU's biggest per capita exporter of goods to the US, its effective tariff rate (ETR) is the second lowest among the member states. That is because of the composition of exports, dominated by pharmaceuticals which have not been tariffed by the US.

My ten cents worth on ten years of fuckery with Robbie Gibb from my time as editor of @Channel4News to trying to get @BBCNews to broadcast our film on Gaza, through No 10, Brexit and Israel the self appointed defender of impartiality, who has utterly destroyed it.

Preprint from Joshua Au Yeung @richdobson and Zeljko Kraljevic @KingsIoPPN on AI's worrying potential for adverse mental health outcomes. The Psychogenic Machine: Simulating AI Psychosis, Delusion Reinforcement and Harm Enablement in Large Language Models.

The View from Westminster newsletter has gone out. Free sign-up here https://t.co/CaHOjrJFyi

Ten years ago, we discovered that reactivating transposable elements triggers an antiviral state in cancer cells, a process we named viral mimicry, unmasking tumors to the immune system (Roulois, Cell 2015). Now this idea finally reached patients with some impressive results:

Reposting this for no apparent reason.

It's so depressing looking at how we are just simply left out. And it is our fault. What an idiotic decision, how can leaving this be a good thing?

Important study, IMO, showing that most highly penetrant pathogenic variants are truly highly penetrant. This might be obvious for clinical geneticists, but i always had a dose of skepticism on the idea of fully deterministic genetic signals.

We are 🅻🅸🆅🅴 comment below & share to join the debate Joining @Peston and @PippaCrerar tonight 👇 🌹@bphillipsonmp 📈 Ruth Curtice 🇵🇸 @afalkhatib 🟢 @ZackPolanski 🔵 @Katie_Lam_MP #Peston

Cool examples here of AI genuinely improving existing cutting edge genetics tools with small, interpretable tweaks (e.g. running a computation in log-log space). For tasks with clear benchmarks, spending ~$1 for AI to look for low hanging optimizations seems very worth it.

Absolutely delighted to see this government investment in mental health research. We hope to have some exciting news for GLAD in the near future.....

Happy to share the news that we have recruited 1000 participants in Ethiopia for @depgenafrica projet ahead of schedule, out of a total of 4,000. This project is the largest genetic study on depression in Africa funded by the @wellcometrust . @psychgenomics , @mcintosh2001

well done!

DNA copy number variation is strongly buffered at the protein level. The buffering is much stronger than at the RNA level.

🚨 Our parent-of-origin study is out in @Nature ! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗 https://t.co/OWW6vGxGYI Highlights below!

Nice systematic analysis of gene convergence between common and rare variant GWAS discoveries. Not often we see common and rare variant studies implicating the same set of genes for a trait. This convergence is rare particularly for traits under strong selection like early

Pleased to share our new preprint on the 1st large-scale GWAS meta-analysis of panic attacks and panic disorder 👇