Daniel De Carvalho
@decarvalho_lab
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Scientist working on Cancer Epigenomics, Immunology, Liquid Biopsy, and Transposable Elements. Faculty @pmcancercentre and @UofTmedicine. Founder, https://t.co/FJYiJmIpBX
Toronto
Joined February 2014
Excited to have this paper out @Annals_Oncology with a concomitant oral presentation @myESMO #ESMO24 ! This is the culmination of our original cfMeDIP-seq work supported by @thePMCF into a clinical validation study for a tissue-agnostic MRD test in Head & Neck cancer.
📢@ESMO24 concomitant paper: Clinical validation of a tissue-agnostic genome-wide methylome enrichment MRD assay for head and neck malignancies. #ESMO24 #HeadandNeckCancer @adela_bio @UHN_Research @decarvalho_lab @ScottBratman
https://t.co/3zXRaa6deV
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Ten years ago, we discovered that reactivating transposable elements triggers an antiviral state in cancer cells, a process we named viral mimicry, unmasking tumors to the immune system (Roulois, Cell 2015). Now this idea finally reached patients with some impressive results:
Now online in @CD_AACR: Priming with DNMT Inhibitors Potentiates PD-1 Immunotherapy by Triggering Viral Mimicry in Relapsed/Refractory NK/T-cell Lymphoma - by Cheng Huang, Yan Gao, Jianfeng Chen, Choon Kiat Ong, Huiqiang Huang, and Jing Tan https://t.co/xAcwfU03hW
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We are thrilled to have Daniel De Carvalho (@decarvalho_lab) from Princess Margaret Cancer Centre / University of Toronto as our Keynote speaker at #EREHD25. What a way to close 3 days of wonderful science. Thank you for being with us in Mexico Daniel!
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🎉 Exciting news! Our new publication, in collaboration with Dr. Song group has just been published in @NatureCellBio In this study, we systematically mapped Ψ modifications catalyzed by 12 human stand-alone PUS enzymes. https://t.co/Lw55akzWd0…
https://t.co/WD8bX6ksGs
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Dr. Daniel De Carvalho joins #ISLB25 as a speaker to showcase his research on cancer epigenetics and early detection. His lab at Princess Margaret develops methylation-based liquid biopsy tools and studies viral mimicry. Learn more: https://t.co/MuILLw8i7a
@ChristianRolfo
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Open for submissions! We are excited to announce the launch of our new collection: Viral Mimicry 🦠✨ Submit your latest research exploring how viruses imitate host processes to evade immunity and regulate infection. 🔗 https://t.co/jM58zG8br1
#CallForPapers #ViralMimicry
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Sharing a paper below in @CellGenomics that took us literally 10 years+ (!) to write on the topics of 👇👇👇 * How, exactly, do we quantify viral mimicry - the expression of molecular features usually associated with nonself viruses by our own "self" cells? * Why do we see
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Check out our latest in @trendscancer where rockstar PhD student Laura Rosenberg reviews cancer therapies known to induce innate immune responses via the sensing of Transposable Elements. https://t.co/eEvPtWcv4D
cell.com
Viral mimicry is a cellular state in which the reactivation of silenced transposable elements (TEs) leads to the accumulation of immunogenic nucleic acids, triggering innate immune pathways that...
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Excited to have this paper out today! Repeats mimic pathogen-associated patterns across a vast evolutionary landscape." It was a fun and productive collaboration with Benjamin Greenbaum, John LaCava, Simona Cocco, Petr Ĺ ulc and many others!
cell.com
An emerging hallmark of disease is transcription of pathogen-associated molecular patterns from within the genome–known as viral mimicry. We propose a statistical physics framework to measure...
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Hear from 2025 Gairdner Momentum Award winner Dr. Daniel De Carvalho (@decarvalho_lab) @PMResearch_UHN on October 23 at @MaRSDD! Learn more about his impactful work in cancer epigenetics and his research journey here ➡️ https://t.co/ZcfLBK0jCk
#GairdnerAwards
uhnresearch.ca
Dr. Daniel De Carvalho wins 2025 Gairdner Momentum Award for advancing cancer detection.
Gairdner Science Week Laureate Lectures are back on October 23! Join us for this rare opportunity to hear directly from the 2025 #GairdnerAwards winners as they share the stories and science behind their discoveries. Register here ➡️ https://t.co/0VMOqOrYJX
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Share in the thrill of discovery! Gairdner Science Week is back October 20-23. Join us for a week of groundbreaking science with the world's top experts and #GairdnerAwards winners. Full event lineup and registration → https://t.co/jjmsovS5NJ
#GSW2025
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Are you currently in the ERE related field and want to find new collaborative opportunities? Join our Chairs @ChiappinelliLab, @shenhui1986, @twang5 & @paultaowu at the upcoming Endogenous Retrotransposable Elements & Human Diseases Conference this November! #EREHD25 🎙️Talk
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Don't forget to register for #EREHD25! Our talk submission deadline has been extended to 12 JUNE 2025, so submit your abstract today to join our incredible speaker line up in Mexico this November 🇲🇽 🔗 https://t.co/Ekcr6cYTOQ
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They’re not just passive genomic elements—they’re active players that may hold the key to new therapies. Exciting to see the field gaining attention and momentum.
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Over the past decade, retroelements have become one of the hottest topics in biomedical science, shedding light on evolution, aging, cancer, autoimmunity, neurodegeneration, and more.
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Risky moves: Can blocking “jumping genes” treat diseases and aging? Great piece in Science Magazine highlighting recent efforts to understand and target transposons—also known as "jumping genes"—in human disease and aging.
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Thank you @GairdnerAwards! I'm truly humbled and grateful for this recognition. Science is never a solo journey and this award reflects the hard work, creativity, and persistence of many amazing scientists I had the privilege to work with.
Congratulations to the 2025 Canada Gairdner Award laureates! This year’s laureates represent some of the world’s most significant biomedical and global health research and discoveries. Find out more about these incredible scientists and their award-winning research here:
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Dr. De Carvalho is awarded “For the ground-breaking discovery of the role of transposable elements in regulating anti-tumour immunity through viral mimicry, which holds transformative potential for cancer therapy, and for pioneering the development of a novel blood-based test for
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From the April issue: Chronic #ViralMimicry Induction Following #p53 Loss Promotes Immune Evasion https://t.co/Tjb3Sf7ZC4 By @CharlesIshak @SajidMarhon @DeCarvalho_Lab and colleagues @UHN @pmcancercentre @MDAndersonNews
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