🎉Excited to announce that our paper on the blueprint of the human spliceosome is now out in @ScienceMagazine ! A decade of work with Juan Valcárcel and the incredible team at @CRGenomica to uncover the intricate roles of this essential RNA machinery. https://t.co/azZ4aSlD3s

Please check out our new review on commonalities between vesicular and nonvesicular transport via intrinsically disordered proteins! Hope you will like it!

📯 Our work on a new core splicing factor is out in @MolecularCell! FUBP1 is important for splicing of long introns. Multivalent interactions support spliceosome assembly and intron bridging. Great collab with @Sattler_lab & Luck_lab. Check it out here: https://t.co/eb8TBuRZbr

Gene therapy approach to boost 'cold shock protein'€™ in the brain without cooling protects mice against neurodegenerative disease

Hypothermia in a syringe: Manipulation of RBM3 alternative splicing using antisense RNA therapeutics prevents neurodegeneration at normal temperature. Check our article with @MallucciLab and @OmiqaBio in @EmboMolMed Link: https://t.co/hXvxQfcNqS

Now in @ScienceAdvances: Alternative splicing occurs after step 1 of splicing! Also reveals trans-acting factors for NAGNAG splicing. Thanks to Reinhard and his team, my phantastic students ⁦@FUBiochemistry⁩ ⁦@FU_Berlin and help from @OmiqaBio DOI: 10.1126/sciadv.adf1785

Our next RNA club meeting today at 5 pm will feature the research of @pre_mRCO from Heyd lab @FUBiochemistry and Vanessa Loiacono from Bock lab @MPIMP_Potsdam. Join us in person or via zoom!

GGGOOOAAALLL we made the cover! huge thanks to the team @NatureSMB @sarakosman for highlighting our work! https://t.co/t1nJBDIQnD 🤩😍🥰😊🥲 feelin' all the feels 🥲😊🥰😍🤩

Ever wonder what happens to our brains at lower temperatures? Looks like our neurons enjoy a cool bath – thanks to increased expression of a cold-shock protein, RBM3. Check out our preprint sharing some secrets behind RBM3 cold induction. https://t.co/Z4WvbOkZHy

For further mechanistic insights also check another preprint from @JulieQLin, @DeepakKhuperkar, @MallucciLab, @RueppLab and @ule_lab. https://t.co/PT13hnEC6T

Can we target alternative splicing to treat neurodegenerative diseases? With @MallucciLab and @OmiqaBio we find that a poison exon is responsible for cold induced RBM3 expression. Targeting this exon by ASO-therapy results in neuroprotection in vivo.

Now online @NAR_Open: How a 1°C increase in temperature induces antiviral genes and promotes an immune response! Great work from @_brunalos! https://t.co/gqCx0KJrBn

Here comes the second one from @AlexandraBergf1 . This time also including the great support from Marco (@pre_mRCO) from the lab of Florian Heyd @FUBiochemistry . Happy to be part of this work 🥳 https://t.co/kDL2ca3Y2p

Are stress granules the RNA analogs of misfolded protein aggregates? Both RNA and proteins can form promiscuous interactions. Similar to the protein chaperones, the RNA chaperones limit self-assembly. #RNASpecialIssue #condensates ➡️ https://t.co/3Wt1HPOoVy

The popularity of selected methods for differential #splicing identification. #bioinformatics #methodsmatter

For the first time, researchers have revealed the atomic structure of the human minor spliceosome, according to a new study in Science. The findings provide a framework for a mechanistic understanding of the function of this ribonucleoprotein complex. ($) https://t.co/pwkedGHz4M

Curious about how reovirus can survive in a low-pH environment? Find out more about it in my latest publication on @biorxivpreprint. Thanks to @MRuwolt and all AG Neu for making this possible!

Have you noticed it’s getting chilly in the air? How are plants coping with this? Happy to share the remarkable work of David Guillaume-Schöpfer, who did his PhD in the group, and our amazing collaborators @alexwebblab @lab_costa @Fabrizio_Doc @Jaegerlab https://t.co/Vy0bo3VBHB

Very interesting review. Worth a read:

Now online @emboreports : More insights into the importance of body temperature cycles: How alternative splicing coupled to decay (#NMD) can generate rhythmic gene expression (#circadian)! Thanks to our collaborators from #sfb973 and #Omiqa https://t.co/kPfBbFhpCV