@BorisBogdanow We hope this strategy will be implemented in many search algorithms in the future and become a goldstandard just like separated intra/interlink filtering. Our results align well with the conclusion of another parallel study by Fischer et al. (ec-filter) (2/2)

Newest publication from our lab 🚨 @BorisBogdanow used some of our datasets to show the terrific benefits of fused target-decoy searches and context-sensitive FDR filtering for increasing crosslink identification sensitivity and reliability. (1/2)

Find our fresh peer-reviewed report on “Molecular Architecture of Synaptic Vesicles” here: https://t.co/E7hGfT7sTk We analyzed synaptic vesicles in neurons and in isolation to describe molecules on their surface. 🧠💥🔬

Our DSSO xlinked PPI benchmarking dataset (PXD042173) and Scout ( https://t.co/eyDYUHSMCB) are finally published ( https://t.co/6l6Iq6QVX4)! Both Scout and the PPI dataset will grow. We and the whole XL community are working hard on refining XL search and FDR estimation.

🎉 Science & grilled delights unite! Celebrating the acceptance of the first @Absea_bio - @theliulab joint paper with an amazing BBQ @LeibnizFMP Thanks to BBQ master @MRuwolt for mastering the move from bench to Bratwurst! Published paper will follow soon-keep your eyes peeled👀

@theliulab @Julia_Rta @BorisBogdanow @giulia_glorani @DomenicoAzTe @diogobor

#PhDone Last week I defended my PhD thesis.👨🏼‍🎓 Many thanks for the nice celebration and the coolest gifts. 🤩 But most importantly: thanks to all the friends and colleagues for creating wonderful memories over the past 3.5 years, both inside and outside the lab.

During our investigation of protein pyrophosphorylation, we identified a novel post-translational modification (PTM), which we have termed 'Protein Oligophosphorylation'. https://t.co/dFOJilk9kh

Diving deep into basic research @LNDWBerlin , guided tours @VolkerHaucke @GroupNazare @theliulab @daniel_roderer & Screening Unit and talk by Ralf Schülein @campusbuch #lndw24

Join us in Berlin as a #postdoc or staff scientist! We have several great openings - both academic and joint with industry. We need: protein #massspec or #biochemistry expertise. We offer: cutting-edge infrastructure and an awesome team. DM for more info #TeamMassSpec #hiring

Pyrophosphrylation is an interesting but understudied PTM. In the most recent paper from Fiedler lab at @LeibnizFMP, @JeremyAMMorgan made the first (but large) step towards pyrophosphoproteomics. Still, we're constantly optimizing the workflow. https://t.co/Q4p8eI09dw

Works for synaptic vesicles, too. We used them to validate CLASP, showing it's applicability to other subcellular compartments besides mitos. Cool method/paper, glad to be a part of it.

Take a look at our new preprint on the molecular architecture of synaptic vesicles purified from mouse brains and in neurons grown on grids https://t.co/DQ9JsYcDJ1 🧵👇

⤵️ Louise has improved this great tool while she was visiting our lab. Especially the pairfinder proves extremely useful whenever one works with a new cleavable crosslinker. You can check *which* and *how well* signature ions are being generated (without full search). 😉

What can I say but "try Scout yourself"? Its superior speed allows analyses in parallel to acquisition or multiple reanalyses of data 💻 with varying parameters. Play around with your data! And what's better than starting with the ground-truth✔️ dataset that comes along with it?

Our new Exploris 480 @thermofisher is up and running at the @LeibnizFMP! Thanks @vant_ai and we look forward to this great collaboration! @zwcarpenter @NaefLuca @MRuwolt @Julia_Rta

Uff, what an epic first day of #PDD23. Amazing how diverse the research of PostDocs in Berlin is. And especially the career-session was eye-opening. Thanks to the organizers!

Hope you had a lot of fun coming to our ‘publishing fortune’ booth @LeibnizFMP ! & Happy Halloween! & All the best to you, Ísis and Louise!

👏Congrats for scientific image of the month! XL-MS reveals the unfolded state of a purified protein, most likely caused by time, environmental conditions, modifications, or flexible domains. @mruwolt @theliulab K. Akkaya, E. Nathanail

👀 Congrats, @BorisBogdanow!