ule_lab
@ule_lab
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Welcome to the RNA networks lab! @TheCrick and @UKDRI at King's in London and @kemijski in Ljubljana 🇪🇺
Joined August 2020
Honoured to have written this review with Jernej Ule’s lab on the splicing code, spanning modeling, mechanisms and its implication for therapeutics designs. Wonderful teamwork.
From computational models of the splicing code to regulatory mechanisms and therapeutic implications https://t.co/94P3YXVmsF
#Review by @tiny_captain, @OscarWilkins16, @nils_f_wagner, Julien @gagneurlab & Jernej @ule_lab
@HelmholtzMunich @TU_Muenchen @TheCrick @KingsCollegeLon
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How can cellular signalling swiftly & selectively remodel the transcriptome to drive biological transition? How this switch is orchestrated has been a mystery... 🧵 https://t.co/3z4dcVoztD
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An opinion piece on how phosphorylation of intrinsically disordered domains selectively alters global protein–RNA binding profiles. https://t.co/uYgp0YswvA
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💡Opportunity for a Lab Technician to join Prof Jernej Ule's lab (@ule_lab)! Join Dr Owen G. James (@owengwydz) and a team of researchers working on the roles of ribonucleoprotein complexes (RNP) and their defects in neurodegeneration👉 https://t.co/JtzmelYk8v
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So excited to share our work on RNA motifs in CLIP, which is published here https://t.co/Qc3ZbdlXfk! Read more from @KlaraKuret here: https://t.co/9N5M3cREj4.
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Last few days to go.... please RT
We’re advertising an exciting post-doc @EdinburghUni integrating #scRNAseq & #hIPSC motor neurons to screen for novel small molecules targeting #MND. Come join us in this amazing city & great research centre. Apply by 10.6.22: https://t.co/w79DNg8btp
@EdinUniNeuro @SBSatEd
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Great opportunity to join our team (@FrattaLab) working on an innovative new gene therapy for ALS/FTD. A mix of novel computational (incl. new machine-learning approaches), molecular & cellular biology, all with a real therapeutic aim. Get involved! Link:
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I feel so lucky to join the wonderful community of researchers at UKDRI!
It is a pleasure to announce that our new Centre Director for UK DRI at King’s is Prof Jernej Ule (@ule_lab), an expert in RNA biology and its role in neurodegenerative diseases such as ALS/FTD 🥳🎉🧠 Read more 👉 https://t.co/PSvxadJCRy (1/4)
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Great to have been involved in this study, led by @FrattaLab and @wardm50, now in Nature! Featuring lab members @OscarWilkins16, plus iCLIP data (of course!) from @fcylee and @martinahallegg1. Hopefully this can pave the way to effective precision medicine
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Wahoo!! Read on for some v. cool insights into how YTH proteins function... in yeast the lone YTH protein is loaded at chromatin & travels to cytoplasm where it helps to couple decay of targets to active translation 👯♀️
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Check out our latest preprint entitled “An RNA-binding switch drives ribosome biogenesis and tumorigenesis downstream of RAS oncogene”, out now on @biorxiv: https://t.co/687XYatOvM (1/9)
biorxiv.org
Oncogenic RAS signaling reprograms gene expression through both transcriptional and post-transcriptional mechanisms. While transcriptional regulation downstream of RAS is relatively well-characteri...
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Congrats Sina! Very valuable findings and new methods SPACE and SPACEmap to isolate chromatin components and identify the chromatin-contact regions with high sensitivity.
Chromatin-contact atlas reveals disorder-mediated protein interactions and moonlighting chromatin-associated RBPs
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This is the first manuscript fully done by the Ljubljana satellite of the RNA networks lab! Originated by Aram @amalietti , an incredible software developer who wrote the code, and then taken over by Klara, a PhD student. Real honour working with such talents!
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Chromatin-contact atlas reveals disorder-mediated protein interactions and moonlighting chromatin-associated RBPs
academic.oup.com
Abstract. RNA-binding proteins (RBPs) play diverse roles in regulating co-transcriptional RNA-processing and chromatin functions, but our knowledge of the
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TODAY, 12h, for our #CEDOCSeminar we will have @PauloGameiro8 from @ule_lab @TheCrick to talk about "Metabolism & RNA modifications in gene regulation". 🧑🔬👨🏫 Don't miss it! DM us for the Zoom link 📬🙌
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@ule_lab
https://t.co/g56ZJhcbi1 Latest, a 13C-based assay to quantify the turnover of base modifications in newly transcribed RNA, by mass spectrometry. We uncover the origin of RNA modifications in digested RNA, and assess their sensitivity to metabolic stresses.
jbc.org
Tandem mass spectrometry (MS/MS) is an accurate tool to assess modified ribonucleosides and their dynamics in mammalian cells. However, MS/MS quantification of lowly abundant modifications in...
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After an extremely long time, members of @ule_lab are enjoying an in-person conference in Vienna @viennabiocenter. What a feeling! 🤗 @paraspeckle @martinahallegg1
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And to diverge a bit, aye-aye is a beautiful and endangered night lemur. Also, "a demon that can kill just by pointing a finger". See an aye-aye CLIP here:
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Thanks to Flora, CLIP has become now even more accessible. iiCLIP enables quality control and optimisation via non-radioactive analysis protein-RNA complexes to produce data of high specificity.
Very happy to share our @biorxivpreprint on an improved iCLIP protocol (iiCLIP) and benchmarking from @ulelab!
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Condensates on transposon(-derived) transcripts and regulation of TDP43-RNA interactions. exciting Transposon-RNA biology by Jernej Ule #EMBOMobileGene
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