Pablo Iturbe
@pabloitu94
Followers
70
Following
131
Media
3
Statuses
33
Postdoc at @ImdeaAlimenta. Ex PhD student in Biotechnology at @lasa_lab. Interested in genetics and molecular microbiology. 🧬🧫
Madrid, Comunidad de Madrid
Joined September 2022
Also, the ExcludonFinder is online. Check if your RNA seq data hides excludons and noncontiguous operons!🖥️🧬 https://t.co/fSds8T4bZF
0
0
0
It's never too late. Last july, we publish the last work out of my PhD period. @A_sanmartinb developed a tool (ExcludonFinder) to study antisense transcriptional mechanisms: excludons and noncontiguous operons. Check the article for more info!
academic.oup.com
Abstract. Bacteria regulate neighboring genes via overlapping transcription in untranslated regions (UTRs), forming excludons. This overlap leads to transc
1
0
0
It's always a pleasure to be back at #XXXCongresoSEM to meet up with old friends and meet new colleagues! I had the pleasure to present the work we are doing at @Imdeanutricion, studying the changes that occur in the Microbiota during aging. #microbiome #aging 🧫🔬
0
1
3
Genetic engineering techniques have been used to redirect the metabolism of Pseudomonas putida KT2440 so that it can metabolize the lignin-derived compound DDVA to produce the compound of biotechnological interest 5CVA. Many congratulations to the lead authors! 👏🙌
0
0
2
Happy to share this latest work where I’ve contributed in my own small way during my first research stay in the @CIB_CSIC! Here, a green strategy using Pseudomonas putida for producing the key building block 5CVA is presented. https://t.co/ioXVRTVGLT
pubs.rsc.org
The design of new biocatalysts for funneling lignin depolymerization-derived dimers into added-value compounds is nowadays a major challenge in biological lignin valorization. Biphenyl 5,5′-dehydro...
1
0
4
📖@NatureMicrobiol dedica su portada a los hallazgos del @CBM_CSIC_UAM sobre la presencia del virus de la gripe aviar altamente patogénica en la península antártica ▶️ https://t.co/pHCvYHxSYW En el🧵enlazamos informaciones del proyecto publicadas entre febrero y agosto:
2
33
71
New issue!✨✨ Check out the latest in #metabolism research from across all disciplines. From #bacteriophages and #foodaddiction to #immunometabolism, #diabetes, #cognition, and many more!🍽️🐭👥 https://t.co/woYwxt7Qzb
1
9
50
For the past two years, we have been working on a novel approach to identify origins of transfer by conjugation in plasmids from any bacterial species. We are thrilled to see this work now published in @NatureMicrobiol after thorough peer review! https://t.co/TpTxRy7jjd
nature.com
Nature Microbiology - Characterization of known plasmid oriT features facilitates identification of 21 oriT-containing sequence families which, alongside candidate sequence validation, expands our...
11
66
170
Great article! Big congrats to the authors! 🙌🏽 It seems that noncontiguos operons play a key role in regulating the expression of antiphage defense systems. A highly efficient strategy, indeed!
Latest from the lab! PICI and prophage-encoded Tai proteins protect cells by blocking phage tail assembly. Prophages counter with a mechanism allowing tail formation after induction. Defence and counter-defence genes are organised for expression.
0
0
2
So cool! 👏🏼😯
Very happy to see the “optoscillator” - a synthetic optogenetic oscillator - published! By applying light pulses on growing E. coli colonies and analysing the ring patterns, we observed synchronisation, (subharmonic) resonance, period doubling and chaos! https://t.co/onDfsPLA6o
0
0
1
Better late than never... Many thanks to all the organizers for the invitation to this symposium to talk about microbiota and healthy aging! #XCIISE 🦠
🔚 Cerramos semana y también nuestra participación en el @congresociise en #Murcia. Investigación, salud y envejecimiento en el mismo foro, donde hemos promovido un simposio💬 centrado en las intervenciones en #microbiota que realizamos para el #envejecimiento saludable. #XCIISE
0
0
2
The gut microbiome drives the aberrant immune response observed in IBD patients. Scientists from @harvardmed discovered hundreds of lineages adapted to inflammatory conditions & predictive of disease severity via @cellhostmicrobe:
cell.com
Gut bacteria are implicated in inflammatory bowel diseases (IBDs), but the strain lineages that underlie these associations are unknown. By studying the evolution of gut bacteria across thousands of...
1
17
43
Excited to share our work published in @ScienceMagazine today answering the question: “Where does Cas13 come from?” https://t.co/twJmttYYkx
science.org
The RNA-guided ribonuclease CRISPR-Cas13 enables adaptive immunity in bacteria and programmable RNA manipulation in heterologous systems. Cas13s share limited sequence similarity, hindering discovery...
6
53
193
We're hiring! Our interdisciplinary group at the Centre for Bacterial Resistance Biology (@CBRB_Imperial), Imperial College London, has an opening for a position. If you’re passionate about science and eager to contribute to groundbreaking research, apply now and join our team!
1
114
141
What a great work! Big congrats to all the team! 🙌🏽🎊
🎉 Excited to share our latest paper in @NatureComms We show that biofilm-associated proteins from intestinal microbiota form amyloid structures that exacerbate alpha-synuclein pathologies https://t.co/RyN2NfQ8gJ
0
0
2
A @SciReports paper reports observations of a wild male Sumatran orangutan applying chewed leaves from Akar Kuning—a climbing plant used in traditional medicine to treat wounds—to a wound on his cheek. https://t.co/LctlQKVD3k
2
74
219
Many thanks to all those who have participated in this work! @lasa_lab @A_sanmartinb @Marcet45 @toni_gabaldon
0
0
0
Excited to share the main work of doctoral thesis. In it we establish the atlas of nocontiguous operons of S. aureus. This gene organization structure regulates the transcription of fundamental physiological processes. Read the paper for details!
academic.oup.com
The genes of bacterial operons can be separated by genes transcribed in the opposite direction, so-called non-contiguous operons like the here identified n
3
7
18
OUT NOW 👉 Bacteriophages avoid autoimmunity from cognate immune systems as an intrinsic part of their life cycles @jakob_tr @quiles_nuria @pabloitu94 @lasa_lab @jrpenades
https://t.co/pl8snNTEMJ
nature.com
Nature Microbiology - Prophage-encoded anti-phage defence systems in Staphylococcus aureus protect hosts from superinfection but also prevent autoimmunity via an overlapping gene.
0
13
42
Proud to have contributed to this work lead by @jakob_tr, @quiles_nuria and @jrpenades. We demonstrated how noncontiguous operons serve as a strategy to balance immunity and autoimmunity in different prophages. Read the paper for details! https://t.co/4jVwP8hVpG
nature.com
Nature Microbiology - Prophage-encoded anti-phage defence systems in Staphylococcus aureus protect hosts from superinfection but also prevent autoimmunity via an overlapping gene.
0
0
3