Excited to share our work published in @ScienceMagazine today answering the question: “Where does Cas13 come from?” https://t.co/twJmttYYkx

Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria. https://t.co/OlU6HOLQfK

New work from @stephentang23 et al. that describes a fascinating set of reverse transcriptases involved in antiviral immunity. They synthesize tandem-repeat cDNAs that resemble telomeres, revealing an unexpected bacterial evolutionary origin of telomerase. Check out the thread!

BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

“we need experiments too cheap to meter.”

Today in @Nature , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems. Check out Erin Doherty's and my work from Doudna lab here: https://t.co/ORz0t5CMvX

Cas10 evolved from a tripwire trap defense system!! @ben_a_adler and Erin Doherty cooked with this one!!

Love the framework around identifying deviations from expectations @xiangfu_ml. Source of all frustration and magic in this discipline. Stoked for the team @periodiclabs !!!

Science is not the pursuit of knowledge, but the pursuit of ignorance.

TODAY WE LAUNCH SORA 2, THE WORLDS BEST VIDEO GENERATION MODEL feature you and your friends with raw real world physics, putting an end to the uncanny ai vibes let me show you how insane our model is, featuring me & sam altman:

(New thesis) AI-ification of R&D proteins There’s been an emergence of new papers on computational antibody, peptide, nanobody, and and enzyme design. While these are all relevant for new therapeutics, there’s massive market opportunity in R&D reagents. (This thesis was started

Never going back after experiencing the convenience of having Kapa pcr mix on hand under my bench at 4C. I’d give top dollar for 4C stable golden gate master mixes. Anything to lower activation energy for trying experiments

Excited to share that my PhD thesis work is out in @ScienceMagazine today. We demonstrate robust rearrangement of the human genome using bridge recombinases, performing programmable insertions, excisions, and inversions at megabase-scale.

For decades, human genome editing has been limited to small, localized modifications. Today, in a new paper published in @ScienceMagazine, researchers from the @pdhsu lab show that bridge recombinase technology is capable of large-scale genomic rearrangements in human cells.

The ability to design antibodies against any protein of interest has major implications for medicine, biotech, and basic science. Today, we introduce Germinal, a pipeline for epitope-targeted de novo antibody design achieving  4–22% success rates with efficient experimental

Today, we report Germinal, a method for efficient de novo antibody design, with @santimillef and @SynBioGaoLab. Germinal achieves success rates of 4-22% across diverse epitopes. We make the work fully open, without doing lame things like posting a preprint without methods. 🧵

Just now: @arcinstitute reports the first viable genomes designed using AI. Their Evo models were fine-tuned to create 16 bacteriophages modeled on ΦX174, a virus that infects E. coli bacteria. Some of these AI-generated phages work just as well, or better, at infecting E. coli

Welcome to the age of generative genome design! In 1977, Sanger et al. sequenced the first genome—of phage ΦX174. Today, led by @samuelhking, we report the first AI-generated genomes. Using ΦX174 as a template, we made novel, high-fitness phages with genome language models. 🧵

Many of the most complex and useful functions in biology emerge at the scale of whole genomes. Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵

How do you use a virtual cell to do something actually useful? (2/3) In this second case study, we explore how our research at @NOETIK_ai suggests better inclusion criteria for a real-world, 2024 cancer clinical trial. Link below! As we mentioned in our last essay, the

A simple take on the Transformer: MLP layers are for long-term memory. Attention is for short term memory. The state-of-the-art for efficient MLP layers is the switch-style MoE. The state-of-the-art for efficient attention is likely sliding window attention with sinks. I’m